Protein Alignment Optix and SIX2

DIOPT Version :9

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_005264157.1
• Gene: SIX2 / 10736
• HGNCID: 10888
• Length: 293
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 146/313 - (46%)
• Similarity: 188/313 - (60%)
• Gaps: 61/313 - (19%)

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFR 96
            :||..|:..||..||:.|:..|:||||.||||||| |..::|:   .|:||:|:||||:|.||||
Human     4 LPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLP-ACEHLHK---NESVLKAKAVVAFHRGNFR 64

  Fly    97 ELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTH 161
            |||.|:|:|:|:..::.|||.:||:||||||||||||.||.|.|||||:|||||.:|||||:.::
Human    65 ELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSY 129

  Fly   162 CFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNS 226
            ||||::||:|||||..:|||:|.:|||||:||||..|||.|||||||||||||.||.|.:.:..:
Human   130 CFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERYEENNEN 194

  Fly   227 S---------GMG---CRSRRADGAASPTPSDSSDSDISLGTHSP--VPSSLQLQHSPGSTSNGA 277
            |         |.|   ..|...:...|.||..||.|...|.:..|  :||...|.|.||
Human   195 SNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPG------ 253

  Fly   278 NDREESLSVDDDKPRDLSGSLPLPLSLPLPLASPTHTPPQLPPGYGGGAGAGP 330
                                   |.::|:|:.              ||.||.|
Human   254 -----------------------PSAVPVPVP--------------GGGGADP 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	68/112 (61%)
		homeodomain	158..206	CDD:238039	30/47 (64%)
SIX2	XP_005264157.1	SIX1_SD	9..118	CDD:407119	68/112 (61%)
		homeodomain	129..180	CDD:238039	36/50 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740