DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Optix and six6

DIOPT Version :9

Sequence 1:	NP_001260793.1	Gene:	Optix / 44108	FlyBaseID:	FBgn0025360	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001093696.1	Gene:	six6 / 100101705	XenbaseID:	XB-GENE-483146	Length:	244	Species:	Xenopus tropicalis

Alignment Length:	251	Identity:	171/251 - (68%)
Similarity:	189/251 - (75%)	Gaps:	14/251 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILN-CEAVLRARAVVAYHVGNF 95
            :|.|.||..||..||:|||:|||||||.||||||||| |...|.|| .|:||||||:||:|.|||
Frog     4 LPILNFSPQQVAGVCETLEESGDIERLGRFLWSLPVA-PAACEALNKNESVLRARAIVAFHTGNF 67

  Fly    96 RELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKT 160
            ||||.|:|||||||.||.||||:||||||.||||||||.||||||||||||||||.|||||||||
Frog    68 RELYHILENHKFTKDSYTKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKT 132

  Fly   161 HCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQN 225
            ||||||||.||||||||||||||:||||||:||||.|||||||||||||||||||||||:|....
Frog   133 HCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVL 197

  Fly   226 SSGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDRE 281
            |.|.| .|...|....|           ||:.|...:||..:.:..:.|..::|.|
Frog   198 SQGTG-HSLGPDERGEP-----------LGSASSPAASLSSKAATSAISITSSDSE 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	88/113 (78%)
Optix	NP_001260793.1	homeodomain	158..206	CDD:238039	43/47 (91%)
six6	NP_001093696.1	SIX1_SD	9..122	CDD:318970	88/113 (78%)
six6	NP_001093696.1	homeodomain	130..178	CDD:238039	43/47 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002292
OrthoInspector	1	1.000	-	-		otm48847
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2573
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030