DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and CYTIP

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	317	Identity:	67/317 - (21%)
Similarity:	105/317 - (33%)	Gaps:	102/317 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 SSTASTPQTTTEDDRFVYRGETSMLIDPNIDL---EELLALPETEKLQ-----------VELKKD 324
            |.:..|...|.:|:|.:     .||.|....|   .:.|||..:..|.           || |:|
Human    26 SYSTLTGSLTMDDNRRI-----QMLADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVTVE-KQD 84

  Fly   325 ANGLGITIAGY------VCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQ 383
            ....|..|..|      .|..|..:  .:..:...|.|..:| ::..|.:..::|.|.:|::..|
Human    85 NETFGFEIQSYRPQNQNACSSEMFT--LICKIQEDSPAHCAG-LQAGDVLANINGVSTEGFTYKQ 146

  Fly   384 AVELLKKSGQVVNLR-------LERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATT 441
            .|:|::.||.::.:.       |:|.....|.:.|:|                           |
Human   147 VVDLIRSSGNLLTIETLNGTMILKRTELEAKLQVLKQ---------------------------T 184

  Fly   442 SSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSF----GAGKQLV---------- 492
            ........||:  :|:|..|...:|  ...||:..|....||.|    |.|..||
Human   185 LKQKWVEYRSL--QLQEHRLLHGDA--ANCPSLENMDLDELSLFGPLPGPGPALVDRNRLSSESS 245

  Fly   493 -------AVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTD----PELSDD 538
                   ...||.||....:          :|..:.|..:|.....|    |:..||
Human   246 CKSWLSSMTMDSEDGYQTCV----------SEDSSRGAFSRQTSTDDECFIPKEGDD 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492
		PDZ_signaling	318..400	CDD:238492	21/105 (20%)
		PDZ_signaling	557..643	CDD:238492
		PDZ_signaling	726..807	CDD:238492
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	21/88 (24%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		6/48 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900