DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and Pard3

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	666	Identity:	153/666 - (22%)
Similarity:	252/666 - (37%)	Gaps:	175/666 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 RYLISTGYPEIFGESSTASTPQTTTEDDRF----VYRGETSMLIDPNIDLEELLALPETEKLQVE 320
            |..:|..:|.:..........:..||:|..    |...:|.:...||..|::::.|       |:
Mouse   219 RSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKL-------VQ 276

  Fly   321 LKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAV 385
            :..|...|||.:..:........|:.||.:..|..|:.......||.|:.::...|:.....||.
Mouse   277 VPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQ 341

  Fly   386 ELLKKS--GQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTP 448
            .:.:::  .:|:...:.......::|||.|....|     .:||..|  |....||..|.|...|
Mouse   342 HMFRQAMRARVIWFHVVPAANKEQYEQLSQREKNN-----YSPGRFS--PDSHCVANRSVANNAP 399

  Fly   449 SRSITRELEEEALP-APEAFMTTPPSVTTMTTTTLSSFGAGKQLVA---VRDSLDGSTK------ 503
                      :||| ||.  ::.||                :||.|   :..|...|||
Mouse   400 ----------QALPRAPR--LSQPP----------------EQLDAHPRLPHSAHASTKPPAAPA 436

  Fly   504 IIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVG 568
            :.|..|:       :.|.|.:    |.|                 |.||..:.:   |:|| ...
Mouse   437 LAPPSVL-------STNVGSV----YNT-----------------KKVGKRLNI---QLKK-GTE 469

  Fly   569 GLGISLEG-TVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAI 632
            |||.|:.. .|.:.|...:    |:::|||.|....:|.|::||.|:||||..|.|.:..|||::
Mouse   470 GLGFSITSRDVTIGGSAPI----YVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSL 530

  Fly   633 LKELPLDVRMVCGRNRNSSLLPF-SDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGD 696
            |:...::..:        |||.| .::.......|.|.....|.:..||:.:..:.|    .||
Mouse   531 LRSTKMEGTV--------SLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLT----PDG- 582

  Fly   697 SVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSL 761
                 ...|...:    .||..              .|..|||.|:...:...:..|..|.::|:
Mouse   583 -----TREFLTFE----VPLND--------------SGSAGLGVSVKGNRSKENHADLGIFVKSI 624

  Fly   762 VPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALK------GASKGVVRIGVAK------- 813
            :.||.|..||||...|:|:.||..:|...:..:|::.|:      |..:|::::.||:
Mouse   625 INGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNE 689

  Fly   814 ----------PLPM---TDNSLKACSNASTTSEETLDAQPSPPAL--------------PTVAPP 851
                      .||:   .|:..:..|::..:..|.||..|:..|.              |||
Mouse   690 LRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGESGKCQLSPTV--- 751

  Fly   852 AMPPSASMGAEPDLIP 867
            .||...::..|.|.:|
Mouse   752 NMPHDDTVMIEDDRLP 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492
		PDZ_signaling	318..400	CDD:238492	17/83 (20%)
		PDZ_signaling	557..643	CDD:238492	29/86 (34%)
		PDZ_signaling	726..807	CDD:238492	24/86 (28%)
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230
		PDZ_signaling	272..347	CDD:238492	17/81 (21%)
		PDZ_signaling	465..544	CDD:238492	30/91 (33%)
		PDZ_signaling	588..681	CDD:238492	26/110 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810