DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and DLG5

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	1175	Identity:	216/1175 - (18%)
Similarity:	356/1175 - (30%)	Gaps:	497/1175 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSADISSALQQIEAVKK-----------GIDESDDPKLQMQTAESLSTILGILQDPVFR---TIV 53
            ::.|...|.:::|.::|           .:.|:|..|.:              :|..|:   .||
Human   484 VTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCR--------------RDWAFQERDKIV 534

  Fly    54 HVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSG 118
            ..:||:..|...|.:......::.              .|.:...|:.|...:        |.|.
Human   535 AERDSIRTLCDNLRRERDRAVSEL--------------AEALRSLDDTRKQKN--------DVSR 577

  Fly   119 GVGE-EPRPQSQNSKGAGVADLYA---------TDYAQIQAIELVN--------DGTGLGFGIIG 165
            .:.| :.:.:||..|.|....|.|         ||..:.:. |:|.        |...|||.:..
Human   578 ELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWET-EVVEFERETEDIDLKALGFDMAE 641

  Fly   166 ARNS-------GVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQ-VAAVLRQSGTHVR 222
            ..|.       |:.|..:..|.:|  |||||..|.:|:|.||:|.....:| :.|:|...|. :.
Human   642 GVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGA-IN 703

  Fly   223 LVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDD 287
            :||.|  .:|:        .|..|.|..:                 .:.|:.
Human   704 MVVRR--RKSL--------GGKVVTPLHI-----------------NLSGQK------------- 728

  Fly   288 RFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSP 352
                        |..|.||                                    :|::..:|.|
Human   729 ------------DSGISLE------------------------------------NGVYAAAVLP 745

  Fly   353 GSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPK---------F 408
            ||.|...|.:.|.|||:.::|.:|...|.::...||:.....:.|.|.:..  |:         |
Human   746 GSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVF--PQSSSWSGQNIF 808

  Fly   409 EQLQQAIAANDKLPS-SAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAP----EAFM 468
            |.::.    :||:.| .|.|...:|.....:...:::|.| ....|..||:...|.|    .:|:
Human   809 ENIKD----SDKMLSFRAHGPEVQAHNKRNLIQHNNSTQT-DIFYTDRLEDRKEPGPPGGSSSFL 868

  Fly   469 TTP-------------PSVTTMTTTTLSSFGAGKQ---LVAVRDSLDGSTKIIP--TEVVPLA-- 513
            ..|             ||.:..:.::..|..:|.:   ||.||    |...::|  |||.|..
Human   869 HKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVR----GRRPLLPFETEVGPCGVG 929

  Fly   514 ----DK--TEAKNSG------------VITRHKYYTDPE-------------------------- 534
                ||  :|..|||            |..:...|..|:
Human   930 EASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPG 994

  Fly   535 ---------------------------------LSDDAETEIIRKWQKIVGS------------D 554
                                             |...:|:|     ..:|||            |
Human   995 PGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESE-----ATLVGSSPSTSPPSALPPD 1054

  Fly   555 VE--------------------------------------------------------------- 556
            |:
Human  1055 VDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSF 1119

  Fly   557 -------VIVAQIKKF-----AVGGLGISLE-------------------------GTVDVEGGR 584
                   ||.||..:.     |.|.|...|:                         |||.    |
Human  1120 RPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVP----R 1180

  Fly   585 EVRPHHYIRSILPD----------------------GPVGVN-GVLRSGDELLEVNGERLLGMNH 626
            .:.|...:.|||.:                      ||.|:: .|...|...|:::.......:.
Human  1181 SLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSE 1245

  Fly   627 LEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGS 691
            :........||...|:     .:||.|.|..:.:|         :|:|.|..::.. ||  ..||
Human  1246 MRATHGSNSLPSSARL-----GSSSNLQFKAERIK---------IPSTPRYPRSVV-GS--ERGS 1293

  Fly   692 VADGD---------------SVAAAAASFSKLKSRSLEPLTGLA------MWSSQPQIIELVKGD 735
            |:..:               |.:.:..|.|.|...::.| ..|.      .:..:|:.:::.||.
Human  1294 VSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNP-ASLGERRKDRPYVEEPRHVKVQKGS 1357

  Fly   736 RGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALK 800
            ..||.||:..:      ...|.:..:..|.:|...| |..||:||..|.|||.:|: :|..:.:.
Human  1358 EPLGISIVSGE------KGGIYVSKVTVGSIAHQAG-LEYGDQLLEFNGINLRSAT-EQQARLII 1414

  Fly   801 GASKGVVRIGVAKPLPMTDNSLKACSNAST-----TSEETLDAQ-PSPPALPTVAPPAM------ 853
            |.....:.| :|:..|.. :.|.:.|.:|:     .:..||... .:.|..|:|..|.|
Human  1415 GQQCDTITI-LAQYNPHV-HQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGP 1477

  Fly   854 --PPS 856
              ||:
Human  1478 STPPA 1482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	13/71 (18%)
		PDZ_signaling	154..226	CDD:238492	25/87 (29%)
		PDZ_signaling	318..400	CDD:238492	17/81 (21%)
		PDZ_signaling	557..643	CDD:238492	25/138 (18%)
		PDZ_signaling	726..807	CDD:238492	23/80 (29%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259	21/138 (15%)
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863	26/152 (17%)
		PDZ_signaling	620..707	CDD:238492	26/89 (29%)
		DegQ	<702..771	CDD:223343	25/156 (16%)
		PDZ_signaling	722..790	CDD:238492	21/145 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		17/199 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		5/40 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		9/46 (20%)
		PDZ	1347..1429	CDD:214570	25/90 (28%)
		dbPDZ_assoc	1427..1499	CDD:293216	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		12/49 (24%)
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810