DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Pard3

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_112514.1	Gene:	Pard3 / 81918	RGDID:	620374	Length:	1337	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	152/661 - (22%)
Similarity:	252/661 - (38%)	Gaps:	165/661 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 RYLISTGYPEIFGESSTASTPQTTTEDDRF----VYRGETSMLIDPNIDLEELLALPETEKLQVE 320
            |..:|..:|.:..........:..||:|..    |...:|.:...||..|::::.|       |:
  Rat   219 RSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKL-------VQ 276

  Fly   321 LKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAV 385
            :..|...|||.:..:........|:.||.:..|..|:.......||.|:.::...|:.....||.
  Rat   277 VPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQ 341

  Fly   386 ELLKKS--GQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTP 448
            .:.:::  .:|:...:.......::|||.|.     ::.:.:||..|  |....||..|.|...|
  Rat   342 HMFRQAMRARVIWFHVVPAANKEQYEQLSQR-----EMNNYSPGRFS--PDSHCVANRSVANNAP 399

  Fly   449 SRSITRELEEEALP-APEAFMTTPPSVTTMTTTTLSSFGAGKQLVA---VRDSLDGSTKIIPTEV 509
                      :||| ||.  ::.||                :||.|   :..|...|||  |...
  Rat   400 ----------QALPRAPR--LSQPP----------------EQLDAHPRLPHSAHASTK--PPTA 434

  Fly   510 VPLADKTEAKNS-GVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGIS 573
            ..||.......| |.:    |.|                 |.||..:.:   |:|| ...|||.|
  Rat   435 PALAPPNVLSTSVGSV----YNT-----------------KRVGKRLNI---QLKK-GTEGLGFS 474

  Fly   574 LEG-TVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELP 637
            :.. .|.:.|...:    |:::|||.|....:|.|::||.|:||||..|.|.:..|||::|:...
  Rat   475 ITSRDVTIGGSAPI----YVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTK 535

  Fly   638 LDVRMVCGRNRNSSLLPF-SDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAA 701
            ::..:        |||.| .::.......|.|.....:.:..||:.:..:.|    .||
  Rat   536 MEGTV--------SLLVFRQEEAFHPREMNAEPSQMQSPKETKAEDEDIVLT----PDG------ 582

  Fly   702 AASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGV 766
            ...|...:    .||..              .|..|||.|:...:...:..|..|.::|::.||.
  Rat   583 TREFLTFE----VPLND--------------SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGA 629

  Fly   767 AQLDGRLIPGDRLLFVNSINLENASLDQAVQALK------GASKGVVRIGVAK------------ 813
            |..||||...|:|:.||..:|...:..:|::.|:      |..:|::::.||:
  Rat   630 ASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPG 694

  Fly   814 -----PLPM---TDNSLKACSNASTTSEETLDAQPSPPAL--------------PTVAPPAMPPS 856
                 .||:   .|:..:..|::..:..|.||..|:..|.              |||   .||..
  Rat   695 SPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGESGKCQLSPTV---NMPHD 756

  Fly   857 ASMGAEPDLIP 867
            .::..|.|.:|
  Rat   757 DTVMIEDDRLP 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492
		PDZ_signaling	318..400	CDD:238492	17/83 (20%)
		PDZ_signaling	557..643	CDD:238492	29/86 (34%)
		PDZ_signaling	726..807	CDD:238492	24/86 (28%)
Pard3	NP_112514.1	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..263		8/43 (19%)
		PDZ_signaling	272..347	CDD:238492	17/81 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..441		18/73 (25%)
		PDZ_signaling	465..544	CDD:238492	30/91 (33%)
		PDZ_signaling	588..681	CDD:238492	26/110 (24%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269\|PubMed:9763423	712..936		14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1015
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1337
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1055
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810