DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Dlg5

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	1075	Identity:	221/1075 - (20%)
Similarity:	371/1075 - (34%)	Gaps:	301/1075 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSADISSALQQIEAVK-----------KGIDESDD-----PKLQMQTAESLSTILGILQ--DPVF 49
            |..::..|||:.:..|           |.:.|.|.     ..|:.:...::|.:...|:  |...
Mouse   505 LCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTR 569

  Fly    50 RTIVHVQDSLSELNA------------------QLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMY 96
            :....|...|.|||:                  ||..|.|   :|..||..     |:.....:.
Mouse   570 KQKNDVSRELKELNSCVHREQMECQLEKEARFRQLMAHSS---HDSAIDTD-----SMEWETEVV 626

  Fly    97 DFDEQRSSSHSHSAPGSPDKSGGVGEEPRP------QSQNSKGAGVAD--LYATDY-AQIQAIEL 152
            :| |:.:......|.|. |.:.||.|...|      .::..||: :||  |...|: .:|..::|
Mouse   627 EF-ERETEDIDLKALGF-DMAEGVNEPCFPGDCGIFVTKVDKGS-IADGRLRVNDWLLRINDVDL 688

  Fly   153 VN-----------DGTG-----------LGFGII-----------GAR--------NSGVIVKTI 176
            :|           :|.|           ||..::           |:|        .:||....:
Mouse   689 INKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKGSRPQDSGISLENGVYAAAV 753

  Fly   177 LPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQ-------------------SGTHV- 221
            :||..|.|:|.|..||.|:.|..:.|......:..::||.                   ||.::
Mouse   754 VPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIF 818

  Fly   222 -------RLVVARPVEQSVPTP------QYALEPGTAVVPTRVLVDPAELERYLISTGY-PEIFG 272
                   |::..|.....|...      |:.....|.:..|..|.|..||.....|:.: .:.|.
Mouse   819 ENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFS 883

  Fly   273 ESSTASTPQ---TTTEDDRFVYRGETSM-----LIDPNIDLEELLALPETE-----KLQVELKK- 323
            .||:..:||   :|:|.....:|.:||.     |:|.. ....||:. |||     .::|.|.|
Mouse   884 GSSSPVSPQACPSTSERSLNSFRSDTSAERGYGLVDMR-SQRPLLSF-ETEVGPCGAVEVPLDKI 946

  Fly   324 --DANGLGIT----IAGYVCEKEELSGIFVKSVSPGSAADLS--GRIRVNDRIIEVDGQSLQGYS 380
              :.:..|.|    :.|.....|:|| ::.|.....|..|.:  .|.:...:|    ...|.|..
Mouse   947 DPEGSNSGGTWPKAVLGSTSGPEKLS-VYKKPKQRKSIFDPNTFKRPQTPPKI----DYLLPGPG 1006

  Fly   381 NHQAVELLKKSGQVVNLRLERYLRGPKFE-QLQQAIAANDKLPSSAPGT-PSRAPMPTPVATTSS 443
            ...:.:..|:.|.:...:..|.....||: :|:.:..:...|..|:|.| |..||.|:...:..:
Mouse  1007 LTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSAPPPSMDPSEPT 1071

  Fly   444 ATTTPSRSITR---------ELEEEALPAPEAFMTTPPSVTTMTTTTLSSFG----AGKQLVAVR 495
            ..:.|.::..|         :.:...|||.:      |....:|:..:...|    ..|...:.|
Mouse  1072 HASPPRKARVRIASSYHSEGDGDTSYLPAKK------PCDEDLTSQKVDELGQKRRRPKSAPSFR 1130

  Fly   496 DSLDGSTKIIPT-------------EVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKW 547
            ..:  |..:||.             |:.|...:....:.|..:||   .:|.|..:
Mouse  1131 PKI--SPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHASRH---GNPLLYPN--------- 1181

  Fly   548 QKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVR-PHHYIRS--ILPDG--PVGVNGVL 607
                            :.:||.:..|:  |.....|..:| |.:.:||  :||.|  ||..:...
Mouse  1182 ----------------RPSVGTVPRSM--TPGTTVGSILRNPIYTVRSHRVLPCGSPPVPRDAGS 1228

  Fly   608 RSGDELLEVNGERLLGMNH--------LEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLS 664
            :|....::..|...|.::|        :........||...|:     .:||.|.|..:.:|
Mouse  1229 QSLSPSVQHQGRLSLDLSHRACSDYSEMRASQGSNSLPSSARL-----GSSSNLQFKAERIK--- 1285

  Fly   665 NNFENLLPATDRLVKAKSDGSLA---------------TAGSVADGDSVAA-----AAASFSKLK 709
               ..|.|...|.|.....|||:               |..|.:...:.|:     |....|..:
Mouse  1286 ---IPLTPRYPRSVMGSDRGSLSHSECSTPPRSPLNIDTLSSCSQPQTTASTLPRIAVNPSSHGE 1347

  Fly   710 SRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLI 774
            .|...|..      .:|:.:::.||...||.||:..:      ...:.:..:..|.:|...| |.
Mouse  1348 RRKDRPFV------EEPRHVKVQKGSEPLGISIVSGE------KGGVYVSKVTLGSIAHQAG-LE 1399

  Fly   775 PGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLDAQ 839
            .||:||..|.|||.:|: :|..:.:.|.....:.| :|:..|....     .|:.:.|...||..
Mouse  1400 YGDQLLEFNGINLRSAT-EQQARLIIGQQCDTITI-LAQYNPHIHQ-----LNSHSRSSSHLDPA 1457

  Fly   840 PSP-----------PALPTVAPPAMPPSASMGAEP 863
            .:|           |..|:|..|.|......|..|
Mouse  1458 ATPHSTLQGSSAGTPEHPSVIDPLMEQDEGPGTPP 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	16/93 (17%)
		PDZ_signaling	154..226	CDD:238492	25/139 (18%)
		PDZ_signaling	318..400	CDD:238492	18/90 (20%)
		PDZ_signaling	557..643	CDD:238492	21/98 (21%)
		PDZ_signaling	726..807	CDD:238492	22/80 (28%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117	11/58 (19%)
		PDZ_signaling	625..712	CDD:238492	20/89 (22%)
		PDZ_signaling	<741..800	CDD:238492	15/58 (26%)
		PDZ	1357..1439	CDD:214570	24/90 (27%)
		dbPDZ_assoc	1437..1512	CDD:374667	13/61 (21%)
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900