DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and TJP1

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_016878010.1	Gene:	TJP1 / 7082	HGNCID:	11827	Length:	1878	Species:	Homo sapiens

Alignment Length:	1008	Identity:	196/1008 - (19%)
Similarity:	326/1008 - (32%)	Gaps:	326/1008 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PGSPDKSGGVG--EEPRPQSQNSKGA--GVADLYATDYAQIQAIEL------------VNDGTGL 159
            |.|.:.:|...  .:.:|..:..||.  ....|.:.|:.::.:..:            ::...|.
Human    61 PSSENPNGATSSVSQGKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGF 125

  Fly   160 GFGII--GARN--------SGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVL 214
            ||||.  |.|:        :.:::..:|.||.|  :|:|:..|.:..:..|::..:........|
Human   126 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQL 188

  Fly   215 RQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLIS-----TGYPEIFGES 274
            |:||.:.::.:.|..:..:|..:...||          |...|.:.|...     :|...:....
Human   189 RKSGKNAKITIRRKKKVQIPVSRPDPEP----------VSDNEEDSYDEEIHDPRSGRSGVVNRR 243

  Fly   275 STASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANG--LGITIAGYVC 337
            |....|:     ||...|..:   :.|..|...:.:....:..:|.|.|....  .|:.:|
Human   244 SEKIWPR-----DRSASRERS---LSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA---- 296

  Fly   338 EKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLER- 401
                 |.||||.:|..|.|...|.|:..|.:::::|...:..|...|..|:::|...:.:.::|
Human   297 -----SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 356

  Fly   402 ----YLRGPKFEQLQQAIAANDK--------LPSSAPG---------TPSRAP--MPTPVATTSS 443
                .|..|.......:..|:::        |.|...|         :.||:|  ...|...:..
Human   357 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRH 421

  Fly   444 ATTTPSRSITRELEEEALPAPEAFMT--------TPPSVTTMTTTTLSSFGAGKQLVAVRDSLDG 500
            :...||....|..:||.:..|.|..|        ||.:|..:|.....     ||..::.:
Human   422 SPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNE-----KQTPSLPE---- 477

  Fly   501 STKIIPTEV-VPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKK 564
             .|.:..:| .|..|...:.:.||:....:          |..|:|...|:|            |
Human   478 -PKPVYAQVGQPDVDLPVSPSDGVLPNSTH----------EDGILRPSMKLV------------K 519

  Fly   565 FAVG-GLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLE 628
            |..| .:|:.|.|..||        ..::..:|.|.|....| |..||::|.||......:...|
Human   520 FRKGDSVGLRLAGGNDV--------GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREE 575

  Fly   629 VVAILKELPL--DVRMVCGRNRN----------------SSLLPFSDDTLKKLSNNFENLLPATD 675
            .|..|.:||.  :|.::..:.::                .:...:..::...||.|...:....|
Human   576 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVD 640

  Fly   676 RLVKAKSDGSLA-----------------------------TAGSVADGDSVAAAAASFSKL--- 708
            .|...|....||                             |....|.||     .|.|.:.
Human   641 TLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD-----RADFWRFRGL 700

  Fly   709 --------KSRS------------------------LEPLTGLA---------MWSSQPQIIELV 732
                    |||.                        |.|:|...         :...:|.|.::.
Human   701 RSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIA 765

  Fly   733 KGD--------RGLGF-------SILDYQDP---LD--PN--DTL-------IVIRSLVPG---G 765
            |.:        |..|.       .|:| ||.   ||  ||  |.|       ||: .|.|.   |
Human   766 KSEPRDAGTDQRSSGIIRLHTIKQIID-QDKHALLDVTPNAVDRLNYAQWYPIVV-FLNPDSKQG 828

  Fly   766 VAQLDGRLIPGDRL------------------LFVNSINLEN------ASLDQAVQ----ALKGA 802
            |..:..||.|..|.                  ||..:|||.:      .:|.:|:|    .|...
Human   829 VKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 893

  Fly   803 SKGVVRIGVAKPLPMTDNSLKACSNA-------STTSEETLDAQP-------------------- 840
            |:|......:..|.:.|:.|...|..       ||.|..|.|.:.
Human   894 SEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDE 958

  Fly   841 --SPP--ALPTVAPPAMPPSASMGAEPDLIPDW 869
              :||  |:...:.|....|:.|..|....|.:
Human   959 VGTPPESAITRSSEPVREDSSGMHHENQTYPPY 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	19/81 (23%)
		PDZ_signaling	318..400	CDD:238492	21/83 (25%)
		PDZ_signaling	557..643	CDD:238492	24/88 (27%)
		PDZ_signaling	726..807	CDD:238492	36/140 (26%)
TJP1	XP_016878010.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860