DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Pdzph1

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	772	Identity:	145/772 - (18%)
Similarity:	238/772 - (30%)	Gaps:	286/772 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLV 86
            |:|::.    ::|.|...:|.|.||..........||....:::..:..|:          .|:.
Mouse   337 DDSEEG----ESATSPQKVLQITQDKPLEQHCFTADSCLPTSSETLRTTSL----------NNVD 387

  Fly    87 LSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIE 151
            ||....|...|.||:|.:|.......:||      .:.:|.:..:.|         ..:.:.:|.
Mouse   388 LSKMSLEDSRDVDEERKNSSDVRENITPD------SQVQPCTAGTNG---------PLSAVNSII 437

  Fly   152 LVNDGTGLGFG--------IIGAR--NSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMV 206
            .:.|.:|..|.        ::||:  |.|...:..|||     :|...|...:..         |
Mouse   438 PIQDASGSEFSPLSFLTLQLLGAKADNMGCRGEETLPG-----EGHESSNSLLFP---------V 488

  Fly   207 SEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIF 271
            |||.|.                     |:|  .|.|...|....   :|.|      :||
Mouse   489 SEQAAK---------------------PSP--LLSPSHRVSRCS---EPVE------TTG----- 516

  Fly   272 GESSTASTPQ---TTTEDDRFVYR--GETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGIT 331
               :|.|..|   ...|.::..||  .:.|:..|.:.:::.|            .:||.....:|
Mouse   517 ---NTFSFSQYIGVEREQEKVHYRLINKASLHNDSSSNIQPL------------ERKDPQSPAVT 566

  Fly   332 IAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVN 396
            ||.  |      .|.|.. ||     |.|.|..:     |:....:.::||     .:::|.
Mouse   567 IAS--C------SILVPK-SP-----LHGNIHSS-----VEWNQTEDHANH-----AERAGL--- 604

  Fly   397 LRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMP--TPVATTS--------SATTTP--- 448
            .|:|..:......:|:|::|..:...|:   ..|.:||.  .|..:||        ::...|
Mouse   605 SRMEVPVMASITNELEQSLATQNYKEST---VDSNSPMAIRNPRESTSYLENVGDDASQALPVVK 666

  Fly   449 ------SRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDS---------- 497
                  ...:|||.:.|.....: |:......|::..||...|...|.|.:..||
Mouse   667 NMCHRNFEDLTRENQNEICSQMD-FLQNSSESTSVGHTTEKLFLIDKTLASDDDSNSNRDHKTCG 730

  Fly   498 --------------------LDGSTKIIPTEV--------------VPLADKT-EAKNSGVITRH 527
                                .:...:..||||              ..|.|:. |..|...:::.
Mouse   731 LNNFQQEPAECQRTTSRVYCEESGNQRYPTEVSCHPVDILLSPQKQKALKDQNLEINNPRKLSQE 795

  Fly   528 KYYTDPELSDDAETEIIRKWQK-------------IVGSDVEVIVAQIKKFAVGGL------GIS 573
            ........||.::.|.|.:|.:             ..||.|      |..|..|.:      .:.
Mouse   796 LALRGGRASDGSQEEAIEQWARRRQQFKDGKRCSSAGGSSV------ISNFTEGSITSDDVHSVD 854

  Fly   574 LEGTVDVE--------------------GGREVRPHHYIRSILP--------------------- 597
            ....||:|                    |..|..|....:...|
Mouse   855 FGFRVDIEEKGFYTENFHSTAWVFRGDDGNPEDSPRCLSKKPRPVAVRERTVRLFKGTGDYPWGF 919

  Fly   598 ----DGPVGVNGV----------LRSGDELLEVNGERLLGMNHLEVVAILKELPLDV 640
                ..|:.|..|          |:.||.:|.|||..:..:.|.|.|.:.|: .||:
Mouse   920 RIQFSKPIVVTEVDTNSAAEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAKK-GLDI 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	10/47 (21%)
		PDZ_signaling	154..226	CDD:238492	17/81 (21%)
		PDZ_signaling	318..400	CDD:238492	18/81 (22%)
		PDZ_signaling	557..643	CDD:238492	26/145 (18%)
		PDZ_signaling	726..807	CDD:238492
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	16/74 (22%)
		PH-like	986..1093	CDD:302622
		PH	993..1094	CDD:278594
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900