DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Pdzd2

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	202/887 - (22%)
Similarity:	330/887 - (37%)	Gaps:	211/887 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGII------GARNSG-------- 170
            |.|...|...:.....:..:|.|  .|:...|.|    ||.||.|      |.:..|
  Rat    52 VDESTVPPDHSPPEMEICTVYLT--KQLGDTETV----GLSFGNIPVFGDYGEKRRGGKKRKTHQ 110

  Fly   171 --------VIVKTILPGGVADKDGRLRSGDHILQIG-------DVNLHEMVSEQVAAVLRQSGTH 220
                    :.|..:.....|.|.|::|..|.||.:.       ||.....::||.     .:|..
  Rat   111 GPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVTGASYLAEQC-----WNGGF 170

  Fly   221 VRLVVARPVEQSVPTPQ-----YALEPGTAVVPTRVLVDPAE-----------LERYLISTGYPE 269
            :.|::.|..:|......     .:.|||.  .||..|.|...           :.|..||. .||
  Rat   171 IYLIMLRRFKQKAHVTYNGNSGNSSEPGE--TPTLELGDQTSKKGKRTRKFGVISRPSISK-TPE 232

  Fly   270 IFGESS---TASTPQTTTED--DRFVYRGETSML----------IDPNI-----DLEELLALPET 314
            ....||   ||..|.:..|:  |..:..|....|          ..|::     |.|..|.:|:|
  Rat   233 DSKSSSGCDTADDPNSELENGADPELGNGHAFELENGPHSLKDVAGPHLERSEADSEVELRVPKT 297

  Fly   315 EK---------------------------------LQVELKKDANGLGITIAGYVCEKEELSGIF 346
            |.                                 .::||.|:::||||.::|....|.....|.
  Rat   298 EAPLSDSNDKRRFSKTGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIV 362

  Fly   347 VKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQL 411
            |..|..|.||...||:.:.|.::.::|..|.|.|:.:||.:|:.:..:|.|.:           .
  Rat   363 VTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV-----------A 416

  Fly   412 QQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTT 476
            .:..:|.|.|..::...|.   :.:.|...||.|....:....|.||.:.|| ...:|.|.|..:
  Rat   417 SKESSAEDLLKLTSKSLPD---LTSSVEDMSSWTDNEDQEAAGEDEEGSGPA-AVRVTMPGSEES 477

  Fly   477 M-------TTTTLSSFGAGKQLVAVRDSLDGSTKIIPT-----EVV-----PLADKTEAKNSGVI 524
            .       :...|.|...|.....::..|.|....:.:     |::     |.....|....|
  Rat   478 QDVGSSEESKGNLESPKQGNCKTKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDG-- 540

  Fly   525 TRHKYYTDPELSDDA----ETEIIRK-------------WQKIVGSDVEVIVAQIKKFAVGGLGI 572
               :.::.|:|.|..    |..|::|             |:.|..|.:.:|  .:.|....|||.
  Rat   541 ---RKHSLPQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISII--GLYKEKGKGLGF 600

  Fly   573 SLEGTVD-VEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKEL 636
            |:.|..| :.|...:    ::::|.|:|....:|.|:.|||:|:|||..:.|:...|.:...|::
  Rat   601 SIAGGRDCIRGQMGI----FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 661

  Fly   637 PLDVRMVCGRNR--NSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVA 699
            ...:.::..|.:  :.||.|.|..|....|::     |:    ....|.|:.|..|....|.|..
  Rat   662 RSGLFVLTVRTKLLSPSLTPCSTPTHMSRSSS-----PS----FNTNSGGTPAGGGQEEGGSSSL 717

  Fly   700 AAAASFSKLK-----SRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIR 759
            ...|...|.:     :.:.||..||                 |:|...|    .|:.:...|.|.
  Rat   718 GRKAPGPKDRIVMEVTLNKEPRVGL-----------------GIGACCL----ALENSPPGIYIH 761

  Fly   760 SLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAK-PLPMTDNSLK 823
            ||.||.||:::..|..||::|.|||:|:.:|:|.:....|.....|.||:.:.: |.|.......
  Rat   762 SLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEM 826

  Fly   824 ACSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMGAEPDL 865
            ....|.:|.:|:.:|..||.....:..|::....|:.:|.:|
  Rat   827 DEVIARSTYQESREANSSPGLGTPLKSPSLAKKDSLLSESEL 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	21/100 (21%)
		PDZ_signaling	318..400	CDD:238492	27/81 (33%)
		PDZ_signaling	557..643	CDD:238492	24/86 (28%)
		PDZ_signaling	726..807	CDD:238492	24/80 (30%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492	27/91 (30%)
		PDZ_signaling	590..671	CDD:238492	23/84 (27%)
		PDZ_signaling	729..813	CDD:238492	30/104 (29%)
		PHA03247	<985..1446	CDD:223021
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810