DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and frmpd2

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_021335879.1	Gene:	frmpd2 / 571843	ZFINID:	ZDB-GENE-110315-2	Length:	1116	Species:	Danio rerio

Alignment Length:	648	Identity:	156/648 - (24%)
Similarity:	252/648 - (38%)	Gaps:	162/648 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLA-QHPSMLPNDFDIDVAGNLVLSLNGGEVM 95
            |...||::...|:|   :..:...|:  :|:|...| :..|.|..|....:...:.|..:    :
Zfish   601 QLTHSLASEESIVQ---YAALCRAQN--NEVNDSSADESMSKLCEDIATRIEAKIKLQRD----L 656

  Fly    96 YDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVND-GTGL 159
            .|....:|.....|...:|.:...|.....|......||      .|...:|..:.|..| ..||
Zfish   657 LDNTGSQSPILQRSLCSTPKRGSDVPSVSSPLRDTPTGA------RTPEREIICVSLKKDPKVGL 715

  Fly   160 GFGIIGARNS-----GVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGT 219
            |..|:|...:     |:.:.:::||..||:|||::.|..::.:..::|..|...:.|.:::.|..
Zfish   716 GIVIVGEDTAGKLDLGIFIASVVPGSPADRDGRIKPGGRLISLNQLSLEGMSFSEAADIMQSSSN 780

  Fly   220 HVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTT- 283
            .|.|::::|..|.......:|...:....:.:|.|....:.:|     .|:.   |...||:.:
Zfish   781 DVELIISQPKAQCKRGGSVSLNERSYESQSTILADGRTGDEFL-----DELV---SVMMTPKASN 837

  Fly   284 -----------TEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVC 337
                       .:||   |....|           |::| ..|:..|.|.|....|||:|||.|.
Zfish   838 RLHVPEVRIINAQDD---YSRSAS-----------LISL-RPEEFTVTLMKSGGSLGISIAGGVN 887

  Fly   338 EKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERY 402
            ......||::||:..|..|:..|||:..||::||||..|||:::.||.|.|.::|:||.|.|||
Zfish   888 TGLRYGGIYIKSLVSGGVAEQDGRIQTGDRLLEVDGIRLQGFTDQQAAECLARTGEVVGLVLER- 951

  Fly   403 LRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAF 467
               .....|||           .||:|.       :..|.|..|               |.|
Zfish   952 ---DGGSMLQQ-----------GPGSPQ-------LRNTLSICT---------------PGP--- 977

  Fly   468 MTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTD 532
                               ||.|   .|.|....|...|..:.|                :.|:
Zfish   978 -------------------AGTQ---ARKSCPAITMTRPFNIKP----------------RDYS- 1003

  Fly   533 PELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISL---EGTVDVEGGREVRPHHYIRS 594
             .:|||...|:                 .:|| .:.|||.|.   |.....:.|..||    |::
Zfish  1004 -FVSDDNIQEV-----------------TLKK-RLNGLGFSFFISELNTSRDRGSIVR----IKT 1045

  Fly   595 ILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSD 657
            :.|..|...:|.::.||.:|.:|||.|.|:::..|:.:|:..|.:|||:..|....:|...|:
Zfish  1046 LFPGQPAEESGRIQEGDVILSINGEPLKGLSYQHVLQLLRNSPSEVRMLLCRPAQGTLPAVSE 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	9/38 (24%)
		PDZ_signaling	154..226	CDD:238492	21/77 (27%)
		PDZ_signaling	318..400	CDD:238492	36/81 (44%)
		PDZ_signaling	557..643	CDD:238492	27/88 (31%)
		PDZ_signaling	726..807	CDD:238492
frmpd2	XP_021335879.1	PKc_like	5..154	CDD:328722
		B41	305..506	CDD:214604
		PH-like	502..603	CDD:327399	1/1 (100%)
		PDZ_signaling	702..786	CDD:238492	23/83 (28%)
		PDZ	865..953	CDD:214570	40/91 (44%)
		PDZ_signaling	1010..1096	CDD:238492	29/107 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910