DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and pdzd3b

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001124259.1	Gene:	pdzd3b / 566852	ZFINID:	ZDB-GENE-081022-151	Length:	524	Species:	Danio rerio

Alignment Length:	662	Identity:	122/662 - (18%)
Similarity:	227/662 - (34%)	Gaps:	226/662 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KKGIDE-----SDDPK-----------LQMQTAESLSTILGILQD-------------PVFRTIV 53
            |||||.     :|:.:           |:.:..|:....|.:.:|             |..|:.:
Zfish    22 KKGIDNPVMVTADETERVWNPTPRVCVLRREERETFGFHLRVERDRQGHVIRLLDSPGPAARSGL 86

  Fly    54 HVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSG 118
            ...|.|.|:|      .:.:.|....:|:|:.:..|...|..|   ||..|.
Zfish    87 KDGDRLLEVN------EAFVENLEHTEVSGSQICFLVLDEKAY---EQVVSE------------- 129

  Fly   119 GVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGII---GARNSGVIVKTILPGG 180
              |.:.|..::.::|.|        :.......:..|..|:||.|:   |.:....:  :.:.||
Zfish   130 --GRDLREMAKAARGEG--------WRPPHLCHIRKDAHGMGFNILPVEGEKRKFAV--SPVKGG 182

  Fly   181 VADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVR-LVVARPVEQSVPTPQYALEPGT 244
            .|::.| :|.|||::.|......|:....::.::::..:|:. ||:....|:|....:..:.|..
Zfish   183 AAERAG-VRKGDHLIWIDGAMASELTHSAISKMVKKCSSHMTVLVIDSDTEKSYARRKMPILPAM 246

  Fly   245 A---VVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLE 306
            |   .:|.|    |..|...:...||..:
Zfish   247 ADAENMPYR----PQRLHLVMGPDGYGFL------------------------------------ 271

  Fly   307 ELLALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEV 371
                          |:::..|.|.|:.            .|:.|..||.|:|.| ::..:.::||
Zfish   272 --------------LRQEKGGAGRTVH------------MVREVDKGSPAELGG-VKEGEMLLEV 309

  Fly   372 DGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKL-----PSSAPGTPSR 431
            :|:|....|:...|..:::|||.|.|.    ...|:.......:..:..|     ||:.|.....
Zfish   310 NGESTDPLSHKDVVSNIRQSGQQVTLT----TMTPQGYDFYTKLGLSPLLFCVDVPSALPEVKKE 370

  Fly   432 APMPTPVATTSSATTTPSRSITRELEEEALP--APEAFMTTPPSVTTMTTTTLSSFGAGKQLVAV 494
            .|:            ||         :.|:|  .|:..:...|:|....... ||.|.|..|..|
Zfish   371 IPV------------TP---------KPAVPPVEPQEEVQINPNVRRCILER-SSAGFGFHLGCV 413

  Fly   495 RDSLDGSTKIIP-TEVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVI 558
            :..        | |.:..:|..:..::||:           ...|...|:  ..|.:....:|.:
Zfish   414 QQK--------PGTFISQVAAGSPGQSSGL-----------FQGDVVVEV--NGQNVEKESLEDV 457

  Fly   559 VAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLG 623
            :..:|:   ||..:||                    ::.|         :.|.:.|:.||:.:.
Zfish   458 IMHVKR---GGETLSL--------------------LVVD---------QKGYDWLKQNGKPVT- 489

  Fly   624 MNHLEVVAILKE 635
            :|.||.::.::|
Zfish   490 LNKLETISEVEE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	16/80 (20%)
		PDZ_signaling	154..226	CDD:238492	19/75 (25%)
		PDZ_signaling	318..400	CDD:238492	22/81 (27%)
		PDZ_signaling	557..643	CDD:238492	14/79 (18%)
		PDZ_signaling	726..807	CDD:238492
pdzd3b	NP_001124259.1	PDZ_signaling	44..118	CDD:238492	14/79 (18%)
		PDZ	148..227	CDD:214570	18/81 (22%)
		PDZ_signaling	264..336	CDD:238492	23/134 (17%)
		PDZ	393..473	CDD:214570	21/124 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900