DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and lnx2b

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	822	Identity:	164/822 - (19%)
Similarity:	282/822 - (34%)	Gaps:	303/822 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DDPKLQMQTAESLSTILGILQDPV-----FRTIVHVQDSLSEL----------------NAQLAQ 68
            |..::|:|...:.|.::..|.|.:     ||:...:.....||                .|:..:
Zfish    83 DRQRIQLQQCRASSLLVRNLLDKLAVLCPFRSECELSMQRCELQPHLHNRCPAFKRLREEAERKK 147

  Fly    69 HPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSS--------HSHSAPGSPDKSGGVGEEPR 125
            .||.  |:            |.|.:...|..:.:|:.        .:.|.||..:.:...||:..
Zfish   148 RPSW--NE------------LKGSKSDGDLADAKSAQTIGRTAQLSAPSEPGLVNPAFEEGEDDT 198

  Fly   126 PQSQNSKGAGVADLYATDYAQIQAIELVND--GTGLGFGIIGARNS---GVIVKTILPGGVADKD 185
            |            |..:..|:...:||..:  |..||..|:|.:::   .::::.|:...:..:|
Zfish   199 P------------LRCSLVAEATVVELFREDPGEDLGLRIVGGKDTPLGNIVIQEIVRDSLVARD 251

  Fly   186 GRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSV-PTPQYALEPGTAVVPT 249
            |:|..|||||::.||:|..:...:..||:||..:.:||.|.:  |:.. |.|::..:| :|..||
Zfish   252 GKLAPGDHILEVNDVSLASISHSRAIAVIRQPCSRLRLTVMQ--EKGFKPRPEHHTQP-SASPPT 313

  Fly   250 RVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPET 314
            :                            :|.|.......:
Zfish   314 Q----------------------------SPSTNQNHGTVI------------------------ 326

  Fly   315 EKLQVELKKD--ANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQ 377
               ||.|.|.  :..|||.:    ..|.|..|:|:..:.||..|...|::|.||:::.::||.|:
Zfish   327 ---QVTLVKHERSEALGIKL----IRKSEEPGVFILDLLPGGLAAKDGKLRNNDKVLGINGQDLR 384

  Fly   378 GYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTS 442
            ..:...|.::::.|...||..:.|         ||..         |..|...:
Zfish   385 HGTPESAAQIIQASEMRVNFVVMR---------LQDV---------SEEGGEGQ----------- 420

  Fly   443 SATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPT 507
                  ||...|..|.:.......:|..||          ..|.:.::.|.:
Zfish   421 ------SRGARRVPEPQYFRRHSEYMKEPP----------GGFSSQEKTVTL------------- 456

  Fly   508 EVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGI 572
                   |.|.:.|                                                |||
Zfish   457 -------KKEPRQS------------------------------------------------LGI 466

  Fly   573 SLEGTVDVEGGREVRPH--HYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILK- 634
            :      :.|||:.|..  .||.|:.|.|.:..:|.:::||.||.:||..|..:.:.|.|.:||
Zfish   467 T------IAGGRDCRSRLPVYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEAVTVLKT 525

  Fly   635 ---ELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGD 696
               :..:.:|::         ..|:||                     .:.||.   :||..|.|
Zfish   526 QTAQSTVTLRVI---------QTFADD---------------------EEQDGE---SGSREDMD 557

  Fly   697 SVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIE------LVK-GDRGLGFSIL-DYQDPLDPND 753
            ::...       |...:..:.....|...|..|.      |:| .....||||: .|::  ....
Zfish   558 TMEGP-------KDDDINWVPLWTRWLGLPSCIHWCRDIMLMKTNSESWGFSIVGGYEE--SRGQ 613

  Fly   754 TLIVIRSLVPGGVAQLDGRLIPGDRLLFVN---SINLENASL 792
            ....|:::|||..|..||||..||.::.||   ::.:.|:||
Zfish   614 QPFFIKTIVPGTPAYFDGRLKCGDEIVAVNGVTTVGMNNSSL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	11/65 (17%)
		PDZ_signaling	154..226	CDD:238492	23/76 (30%)
		PDZ_signaling	318..400	CDD:238492	25/83 (30%)
		PDZ_signaling	557..643	CDD:238492	25/91 (27%)
		PDZ_signaling	726..807	CDD:238492	25/78 (32%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492	25/80 (31%)
		PDZ_signaling	325..406	CDD:238492	25/111 (23%)
		PDZ_signaling	451..537	CDD:238492	29/159 (18%)
		PDZ_signaling	587..671	CDD:238492	23/71 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910