DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and PARD3

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	692	Identity:	162/692 - (23%)
Similarity:	263/692 - (38%)	Gaps:	207/692 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 QRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYAT-DYAQIQAIELVNDGTGLGFGI- 163
            ::..|||. .|.|...||.....|....||.....|:..|.| ...:...|:|.....||||.|
Human   413 EQIDSHSR-LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSIT 476

  Fly   164 -----IGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQS---GTH 220
                 ||. ::.:.||.|||.|.|.:||||::||.::::..|:|.....|:|.::||.:   ||
Human   477 SRDVTIGG-SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGT- 539

  Fly   221 VRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTE 285
            |.|:|.|..:              |..|..:..:|::::                   .|:.|..
Human   540 VSLLVFRQED--------------AFHPRELNAEPSQMQ-------------------IPKETKA 571

  Fly   286 DDRFVYRGETSMLIDPNIDLEELLALPETEK----LQVELKKDAN-GLGITIAGYVCEKEELS-G 344
            :|                  |:::..|:..:    .:|.|....: |||:::.|...::.... |
Human   572 ED------------------EDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLG 618

  Fly   345 IFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFE 409
            |||||:..|.||...||:||||::|.|:|:||.|.:|..|:|.|::|...         .|.|..
Human   619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST---------EGNKRG 674

  Fly   410 QLQQAIA-----AND-KLPSSAPG-----------------------------TPSR-APMPTPV 438
            .:|..:|     .|: |.|.|.||                             :||| |.:...:
Human   675 MIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIM 739

  Fly   439 ATTSSATTTPSRSITRE----LEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGK-QLVAVRDSL 498
            ..:.....:|:.::.::    :|::.||.....::...|.::.......:..||. ...|:.||.
Human   740 GESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSA 804

  Fly   499 DGSTKIIPTEVVP-LADKTE--AKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVA 560
            |.|   :..:|.| ||.:.|  .:.|....|.|.::|....|..:|   ||.:.:
Human   805 DCS---LSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKT---RKSKSM---------- 853

  Fly   561 QIKKFAVGGLGISLE---GTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDEL--------- 613
                    .|||:.|   .|||.:           ::..|...||.:..|:....|
Human   854 --------DLGIADETKLNTVDDQ-----------KAGSPSRDVGPSLGLKKSSSLESLQTAVAE 899

  Fly   614 LEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLV 678
            :.:||:          :...:..|   |::.||..|.|.....|.:..|         ||.|
Human   900 VTLNGD----------IPFHRPRP---RIIRGRGCNESFRAAIDKSYDK---------PAVD--- 939

  Fly   679 KAKSDGSLAT------AGSVADGDSVAAAAASFSKLKSRSLE 714
              ..|..:.|      ..|.:..:||:.|    |...|.|||
Human   940 --DDDEGMETLEEDTEESSRSGRESVSTA----SDQPSHSLE 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	30/80 (38%)
		PDZ_signaling	318..400	CDD:238492	32/83 (39%)
		PDZ_signaling	557..643	CDD:238492	16/97 (16%)
		PDZ_signaling	726..807	CDD:238492
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262
		PDZ_signaling	272..347	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		10/35 (29%)
		PDZ_signaling	465..544	CDD:238492	30/80 (38%)
		PDZ_signaling	588..681	CDD:238492	35/101 (35%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		51/280 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		15/62 (24%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		15/59 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810