DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and grip2b

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_021325304.1	Gene:	grip2b / 562290	ZFINID:	ZDB-GENE-070705-172	Length:	1086	Species:	Danio rerio

Alignment Length:	935	Identity:	193/935 - (20%)
Similarity:	320/935 - (34%)	Gaps:	321/935 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IEAVKK-----------GIDESDDPKL-------------QMQTAESLSTILGILQDPVFRTIVH 54
            :|.:||           |.|:...|::             |:...:.:.::.||
Zfish    48 VELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDQLNVGDYIKSVNGI----------- 101

  Fly    55 VQDSLSELNAQLAQHP---SMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDK 116
               :|::|     :|.   |:|.|     |...:||     ||.|:...           .:||.
Zfish   102 ---NLTKL-----RHDEIISLLKN-----VGERVVL-----EVEYELPS-----------AAPDS 137

  Fly   117 SGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGA------RNSGVIVKT 175
            :.||                       .::...|.|..:|...||.:.|.      ::..::|..
Zfish   138 TSGV-----------------------ISKTIEICLQKEGNSFGFVMRGGAHEDWHKSRPLVVTH 179

  Fly   176 ILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYAL 240
            :.|||.||::|.|:|||.||.:..|.||.........||.|.|                  |.||
Zfish   180 VRPGGPADREGTLKSGDRILSVDGVVLHSATHSDALVVLTQCG------------------QEAL 226

  Fly   241 EPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDL 305
                           .::| |.:|     |....:.||.|
Zfish   227 ---------------FQIE-YDVS-----IMDSVTNASGP------------------------- 245

  Fly   306 EELLALPETEKLQVELKKDANG--LGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRI 368
                       |.||:.| |.|  ||:|:...:...::  .|.:..:.|||..|.||.:.|.|.|
Zfish   246 -----------LLVEIAK-APGASLGVTLTTALHRNKQ--AIVIDKIKPGSVVDRSGALHVGDHI 296

  Fly   369 IEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLP---SSAPGTP- 429
            :.:||.|.:..|..:|.:||..:.....|.:                     ||   :..||.|
Zfish   297 LSIDGTSTEHCSLLEATQLLASTSDQTKLEI---------------------LPAHQTRLPGKPQ 340

  Fly   430 ----------------------SRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPP 472
                                  |:.|.....:|.:||::.||.|      ::...:......:|.
Zfish   341 DTVKVQKSDHPHCWDPCVNYCHSQHPGHCKTSTWTSASSNPSSS------QDYCKSVVCSNFSPG 399

  Fly   473 SVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSD 537
            |.||...|:..|                ||  :|....|::    .:||.:..|.:.......|.
Zfish   400 STTTSGMTSQGS----------------ST--LPRAAPPMS----PRNSMLKRRQRKKEHKSSSV 442

  Fly   538 DAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVG 602
            ...:..:....:||.::...:.  ::...:.|.|:.|:|.:.........|  .||.|.||....
Zfish   443 SLASSSVGPGGQIVHTESSEVT--LRGDPLNGFGVQLQGGIFATETLSAPP--LIRFIEPDSSAE 503

  Fly   603 VNGVLRSGDELLEVNG-----ERLLGMNH-LEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLK 661
            ..|:|:.||.:|.:||     ..|...|. |...|:..::.|::..    :...|::|.|.....
Zfish   504 RCGLLQVGDRVLSINGIPTEDGTLEEANQLLRDAALANKVSLEIEF----DVAESVVPSSGTFHV 564

  Fly   662 KLSNN---------FENLLPATDRLVKAKSDGSLA-TAGSVADGDSVAA---------------- 700
            ||...         ..:..|....::.....||:| ..|::..||.:.|
Zfish   565 KLQKKRGVELGITISASKKPGEPLIISDIKKGSMAHRTGTLEPGDKLLAIDNIRLENCSMEDAAQ 629

  Fly   701 ---AAASFSKLKSRSLEPLTGLAMWSSQPQ--------IIELVKGDRGLGFSILDYQDPLDPNDT 754
               .:....|||.|..|.       :|..|        .:||.:....||.:|...::|.||
Zfish   630 ILQQSEDLVKLKIRKDED-------NSDEQESSGSIIYTVELKRYGGPLGITISGTEEPFDP--- 684

  Fly   755 LIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTD 819
             |:|..|...|:|:..|.:..|||:|.:||::|:...|.:|:..|:.|.: .|.:.:.|.....|
Zfish   685 -IIISGLTKRGLAERTGAIHVGDRILAINSVSLKGKPLSEAIHLLQMAGE-TVTLKIKKQADSPD 747

  Fly   820 -----NSLKACSNASTTSEETLDAQ 839
                 |.|:  ::.|...:|..|:|
Zfish   748 EKNKENDLE--NDLSDNEDEMTDSQ 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	11/79 (14%)
		PDZ_signaling	154..226	CDD:238492	24/77 (31%)
		PDZ_signaling	318..400	CDD:238492	26/83 (31%)
		PDZ_signaling	557..643	CDD:238492	22/91 (24%)
		PDZ_signaling	726..807	CDD:238492	26/88 (30%)
grip2b	XP_021325304.1	PDZ_signaling	45..127	CDD:238492	19/107 (18%)
		PDZ	144..232	CDD:214570	30/121 (25%)
		PDZ_signaling	245..328	CDD:238492	28/142 (20%)
		PDZ_signaling	462..548	CDD:238492	22/89 (25%)
		PDZ_signaling	561..643	CDD:238492	13/81 (16%)
		PDZ_signaling	659..740	CDD:238492	26/85 (31%)
		Peptidase_S41	672..>841	CDD:321971	31/106 (29%)
		PDZ_signaling	970..1050	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910