DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and pard3bb

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_690638.6	Gene:	pard3bb / 562146	ZFINID:	ZDB-GENE-070912-290	Length:	1172	Species:	Danio rerio

Alignment Length:	652	Identity:	157/652 - (24%)
Similarity:	250/652 - (38%)	Gaps:	201/652 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSADISSALQQIEAVKKGIDESDDPKLQMQTAESL----------------STILGILQDPVFR- 50
            |...|....:...:.::||.:.|:..:::...|.:                |:|:.:...|||.
Zfish   216 LGLHIRGVEENSRSKREGIFQDDECIVKINDTELMDKSFSQAQEIFRQAMRSSIVRLEVVPVFNK 280

  Fly    51 ------TIVHV-QDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSH 108
                  .|.|: .....:.:||..:.|.:     .:......|.|.:|.:.  :|.|..||..|.
Zfish   281 ERFEKSVISHLFNPETPDASAQTKEPPPL-----KVKPMVRPVESSSGWQA--EFQESSSSLESR 338

  Fly   109 SAPG------SPDKSGGVGEE--------PRP-QSQNSKGAGVADLYATDYAQIQAIELVNDGTG 158
            |...      ||...|...|.        |.| |:.|.||           .:...|:|.....|
Zfish   339 SLGSPLPINLSPTPRGKSAESSLLKNSLGPSPLQNHNKKG-----------GKRLRIDLKKGPEG 392

  Fly   159 LGFGIIGARNSGV------IVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLR-- 215
            |||.:: .|:|.|      :||.|||.|.|.|||||:|||.||::..|::.....|::.|:||
Zfish   393 LGFTVV-TRDSSVHGPGPILVKNILPRGAAVKDGRLQSGDRILEVNGVDIGGRSQEELVAMLRST 456

  Fly   216 QSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTP 280
            :.|..|.|||||..:..:|               |.|.:  |..|.|:|
Zfish   457 KQGDSVCLVVARQEDMFLP---------------RELKE--EQARLLLS---------------- 488

  Fly   281 QTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDAN-GLGITIAGYVCEK--EEL 342
                |:.:                 |:|:       .:|.|....: |||:::.|....:  |:|
Zfish   489 ----EEGK-----------------EQLM-------FEVPLNDSGSAGLGVSLKGNKSRETGEDL 525

  Fly   343 SGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRG-- 405
             |||:||:..|.||...||:|:||::|.|:|:.|.|.|||:|:|.|::|     :.:|..|||
Zfish   526 -GIFIKSIIHGGAAFKDGRLRINDQLIAVNGEPLLGKSNHEAMETLRRS-----MSMEGNLRGMI 584

  Fly   406 ---------PKFEQLQQAIAANDKLPSSAPG-----TPSRAPMPTPVATTS----SATTTPSRSI 452
                     |..::.|:|....::...|..|     :.|.|.:..|:...|    .|.:....:.
Zfish   585 QLVVLRSVLPPNQEFQEARRILNRSFDSCVGQAAHLSQSDAGVQPPMVMNSIYERCAVSNGGYNH 649

  Fly   453 TRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGA-----GKQLVAVR---------DSLDGSTK 503
            |.|.::|...|......:.....::.::.|.|..|     |:|:.|.:         |.:.|...
Zfish   650 TEEGDDEGFDANPHRQNSLQFQQSLLSSGLRSADASLTDGGQQVHAEQNHVKSLKSVDLVSGGVV 714

  Fly   504 IIPT---------EVVPLADKTEAKNSGVITRH---------------------KYYTDPELSDD 538
            :.||         |.:..| .||||.:.::..|                     |.|..|...||
Zfish   715 LGPTLGLKKSSSLESLQTA-MTEAKKNELLPFHRPRPHIVRGRGCNESFRAAIDKSYDGPPEDDD 778

  Fly   539 AE 540
            .|
Zfish   779 DE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	13/81 (16%)
		PDZ_signaling	154..226	CDD:238492	33/79 (42%)
		PDZ_signaling	318..400	CDD:238492	33/84 (39%)
		PDZ_signaling	557..643	CDD:238492
		PDZ_signaling	726..807	CDD:238492
pard3bb	XP_690638.6	DUF3534	1..145	CDD:288873
		PDZ	188..276	CDD:214570	8/59 (14%)
		PDZ_signaling	387..467	CDD:238492	33/80 (41%)
		PDZ_signaling	497..589	CDD:238492	37/97 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910