DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and Tamalin

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	340	Identity:	71/340 - (20%)
Similarity:	107/340 - (31%)	Gaps:	130/340 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ARPVEQSVP---TPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDD 287
            |.|:....|   .|..|  ||..:........||||.|.|..:|          .:.|:  .:..
Mouse    33 AAPLPSGPPAAAAPPGA--PGEELYAALEDYHPAELYRALAVSG----------GTLPR--RKGS 83

  Fly   288 RFVYRGETSMLIDPNIDLEELLALPETEKLQVELKK-DANGLGITIAGYVCEKEELSGI----FV 347
            .|.::..|..              ||.::..:.|:| |....|..|..|.....|...:    ||
Mouse    84 GFRWKNFTQS--------------PEQQRKVLTLEKGDNQTFGFEIQTYGLHHREEQRVEMVTFV 134

  Fly   348 KSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLE------------ 400
            ..|...|.|.|:| :...|.|..|:|.:::|..:.:.|:::|.||.|  ||||
Mouse   135 CRVHESSPAQLAG-LTPGDTIASVNGLNVEGIRHREIVDIIKASGNV--LRLETLYGTSIRKAEL 196

  Fly   401 ----RYLRGPKFE-------------QLQQAIAANDK------------------LPSS------ 424
                :||:...:|             :|...:...|.                  ||.|
Mouse   197 EARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPL 261

  Fly   425 --APGT--------------------------PSRAPMPTPVATT--SSATTTPSRSITRELEEE 459
              |||:                          |...|.|.|.|..  .|:..||:..:
Mouse   262 LAAPGSARGGARRAKGDTDDAVYHTCFFGGAEPQALPPPPPPARALGPSSAETPASVL------- 319

  Fly   460 ALPAPEAFMTTPPSV 474
             .|||.:.::...||
Mouse   320 -FPAPRSTLSRSASV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	71/340 (21%)
		PDZ_signaling	318..400	CDD:238492	26/86 (30%)
		PDZ_signaling	557..643	CDD:238492
		PDZ_signaling	726..807	CDD:238492
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		5/18 (28%)
		PDZ_signaling	99..184	CDD:238492	26/87 (30%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900