DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and grid2ipb

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1023	Identity:	194/1023 - (18%)
Similarity:	328/1023 - (32%)	Gaps:	395/1023 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 IVHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDK 116
            |:.|::..|      ||...:.|.|..:::.|..|.||:..||:.....||:         .|..
Zfish    24 ILTVEEGSS------AQLSGLQPGDQVLEIEGQNVSSLSAQEVIALAQSQRN---------IPPS 73

  Fly   117 SGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTG-LGFGIIGARNSGVIVKTILPGG 180
            .|.|                        ::||.:::.....| .||.|:|  :..::|:...|..
Zfish    74 IGVV------------------------SRIQQMDITPGPDGRFGFTIVG--DCPLLVEDCSPCS 112

  Fly   181 VADKDGRLRSGDHILQIGDVNL--HEMVSEQVAAV------------------------------ 213
            .|.:.| ||:||:::::..:.:  |||.:..:.|.
Zfish   113 PAGRSG-LRAGDYVMEVNGIPVKHHEMAAALIKASQGRTLRLGVLCMGSRQKRSSGSLEGLQKDT 176

  Fly   214 --LRQSGTHVRLVVARPVEQSVPT------------PQYALEPG----TAVVP------------ 248
              :||...|..|...|.||:.:..            .|:|.|..    .:|:|
Zfish   177 DGMRQDRKHKALEFNRRVEEILRNEPEVKEKLFAVLKQFAAERKVDWLASVLPDILTTEEQQQLI 241

  Fly   249 --TRVLVDPAELERY-------LI-------STGYPE--------------IFGESSTASTPQTT 283
              .|:.:.....:|:       ||       |.|.|:              ..|....:|.|:.|
Zfish   242 SNIRIFIPKKHRQRFDEAVSQSLINRMCRSKSLGEPQNRLRRSRSQDHHERPQGSKRASSVPRDT 306

  Fly   284 ----TEDDRFVYRGETSMLIDPNIDLEELLALPE-----TEKLQVELKKDANGLGITIAGYVCEK 339
                .::||.:.:..|              .:|.     ..:..:.:.:.....|.|:.|:
Zfish   307 GDEPAQNDRTLRKSNT--------------MIPTQYVSGVNQRTIRVYRGKKSFGFTLRGH---- 353

  Fly   340 EELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLR 404
               :.:::.||.|||.|:..| ::..|||:.::|..::..|:.:.|.:|:.||.:.:|.:|   .
Zfish   354 ---APVWIDSVMPGSPAEACG-LKTGDRILFLNGLDMRNCSHEKVVSMLQGSGAMPSLVVE---E 411

  Fly   405 GP-KFEQLQQAIAANDKLPSSAPGTP-SRAPMPTPVATTSSATTTPS-----RSITRELEEEALP 462
            || .:.|       :|..|...|..| ||:|..:.:...:. ...||     |:.:::||.
Zfish   412 GPVDYPQ-------SDSEPEETPSAPRSRSPALSSLQWVAE-ILPPSIRVHGRTFSQQLEH---- 464

  Fly   463 APEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRH 527
                           ..|....:...|.|.......:..|.|:  :|.|:.| |.||.  :|.:.
Zfish   465 ---------------LLTLQERYTICKALETFFQHRNVDTLIV--DVFPVLD-TPAKQ--LIWQF 509

  Fly   528 KYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYI 592
            .|                  |.:...:.|....:|.:|    ||..   :.:.|.|.|.  |...
Zfish   510 IY------------------QLLTYEEQEHCKTKIARF----LGFK---SAEPEVGAET--HRRS 547

  Fly   593 RSILPDGPVGVNGVL-RSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFS 656
            .|:...|....|.|. ||.|:.       ::| .||.:......:..:.|. ||   :.:..|.|
Zfish   548 SSMRVSGTSHKNTVRERSSDDC-------IIG-THLGMGTFTDPVTPEERQ-CG---DGTSFPES 600

  Fly   657 DDTLKKLSNNFENLLPATDRLVKAKSDGSL-------------------------ATAG------ 690
            .| |..::..:..|    ..:...||..||                         :|||
Zfish   601 PD-LSHMTGVYTEL----GNVYPVKSSQSLQSHSSPRAAGMGLAESNTYTQSFTHSTAGNRKSGL 660

  Fly   691 ------------------SVADGDS------VAAAAASFSKLKSRSLEPL---TGLAMWSSQPQ- 727
                              :||..||      |:..:...|.|.|..|.||   ..|..:|..|:
Zfish   661 SLTWTDSFPGPQFETYQQTVASPDSVDSNPYVSLDSPPASPLPSDELSPLPQRRKLFTFSRPPRS 725

  Fly   728 -------------------IIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRL 773
                               |::..||... .:..:.:||..:.|                    :
Zfish   726 RDTDKFLDALSEQLGHRVNIVDDFKGGEN-DYEEMSFQDEQEVN--------------------M 769

  Fly   774 IPGDRLLFVNSINLE-NASLDQAVQALKGASKGVVRI-----------------GVAKPLPMTDN 820
            :|.:    ::|.:.| ::|.|.:...  ..|.|...|                 ....|||:|..
Zfish   770 LPHE----LSSASSEDHSSSDDSTSV--SYSSGSDHIPPPPQSPPPPPPPLQFTDSPSPLPITPE 828

  Fly   821 SLKACSNASTTSEETLDAQPSPPAL---PTVAPPAMPPSASMGAEPDL 865
            .|               .|| |||.   |.:|||..||...:...|.|
Zfish   829 HL---------------PQP-PPAFQHHPIIAPPPPPPRPFLANRPSL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	5/17 (29%)
		PDZ_signaling	154..226	CDD:238492	21/106 (20%)
		PDZ_signaling	318..400	CDD:238492	20/81 (25%)
		PDZ_signaling	557..643	CDD:238492	19/86 (22%)
		PDZ_signaling	726..807	CDD:238492	14/101 (14%)
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492	14/50 (28%)
		PDZ_signaling	80..156	CDD:238492	19/78 (24%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	12/78 (15%)
		PDZ_signaling	335..410	CDD:238492	20/82 (24%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	20/124 (16%)
		FH2	995..1360	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900