DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and Grip

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	1010	Identity:	201/1010 - (19%)
Similarity:	345/1010 - (34%)	Gaps:	361/1010 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HLSADISSALQQIEAVKKGID--ESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNA 64
            |......:||..:.:|.:.:.  :|:|..|..:...:.:||      .:.|..:|:..:.:|.|
  Fly    43 HHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATI------TLPRNALHLAITFAERN- 100

  Fly    65 QLAQHP-------------SMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDK 116
            .|:..|             .:.|.|....:.|...:.|:..:||    ....:..|.:.|...:.
  Fly   101 DLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVM----NMLCAGGSDACPAIVEI 161

  Fly   117 SGGVGEEPRPQ---SQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILP 178
                 |...|:   ||||       |..|  :::..|.:..:...||..:.|..:..:||..:.|
  Fly   162 -----EYSLPECTVSQNS-------LCVT--SKLAQITVERESGCLGLTLRGGADYPLIVTHVRP 212

  Fly   179 GGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPG 243
            .|...|.||::.||.:|::.:|:|......:...::: .|.||
  Fly   213 HGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK-CGGHV---------------------- 254

  Fly   244 TAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEEL 308
                                 :||           |..|...|...|...|.||
  Fly   255 ---------------------SGY-----------TNLTIEYDVSVVQSVEFSM----------- 276

  Fly   309 LALPETEKLQVELKKDANG-LGITIAGYVC---------------EK-EELSGIFVKSVSPGSAA 356
                  ..|.:|:::..|. ||:.:..|..               || ||.:|:|:.|:.|.|.|
  Fly   277 ------GPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIA 335

  Fly   357 DLSGRIRVNDRIIEVDGQSLQ--GYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAAND 419
            |..|.:.|.|:::.:|...::  .:|..:.:.:|..|            .|..:.|:|
  Fly   336 DRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTS------------TGRGYTQMQ------- 381

  Fly   420 KLPSSAPGTPSRAPMPTPVATTSS----ATTTPSRSITRELEEEALPAPEAFMTTPPSV-TTMTT 479
            .:|:.|........:.:|..:.|:    .::|..|...|...:.:||.......||.|. .:|.|
  Fly   382 IMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGT 446

  Fly   480 TTL---SSFGAGKQL-----------------VAVRDSLDGS--------TKIIPTEVVPLADKT 516
            ..:   ||.|.|..|                 :.:.:::.||        .:|:|..|   ||::
  Fly   447 GGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSV---ADRS 508

  Fly   517 EAKNSG--VITRHKYYTDPELSDDAETEIIR--------------KWQKIVGSDVE------VI- 558
            ....:|  ::..:|.|:   |...|..:::.              .|.::   ::|      |:
  Fly   509 GCIQAGDRIVAINKMYS---LDAAAMRQLLEGGSSRNGASNGTPANWLEL---EIEFDMPDAVVP 567

  Fly   559 ---VAQIKKFAVG--GLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNG 618
               |..:|....|  |||:|:.|:  ..||.      .|..:....|...:|.|||||.||.|:.
  Fly   568 ASGVFSVKLLRAGKCGLGLSVSGS--SHGGL------VISDVKMGSPAHRSGSLRSGDILLAVDQ 624

  Fly   619 ERLLGMNHLEVVAILKELPLDVRMVCGRNRN--SSLLPFSDDTLKKLSNNFENLLPATDRL---- 677
            .   .:.|..|.|:|||.        ||::|  .|...|:..|:|::.  ..:.||.:..:
  Fly   625 H---PVQHFNVDALLKEE--------GRSQNPSHSSSDFTTLTIKRIV--LPDFLPMSSPIYSNC 676

  Fly   678 ------------VKAKSDGSL-----ATAGSVADGDSVAA------------------------- 700
                        |...:|..|     .|||..||..|:.:
  Fly   677 PASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRS 741

  Fly   701 ---------AAASFSK-LKSRS----------------------------------------LEP 715
                     ||.|:|. :.|||                                        |.|
  Fly   742 GSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPP 806

  Fly   716 -----LTGLAMWSSQP-------QIIELVKGD-RG--LGFSILDYQDPLDPNDTLIVIRSLVPGG 765
                 :.|.|..||..       |||..|:.: :|  ||.::...:|....    |.|..||.||
  Fly   807 PMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKS----ITISGLVEGG 867

  Fly   766 VAQLDGRLIPGDRLLFVNSINLENASLDQAVQALK 800
            :|..:|::..||:||.::..:::...|..|...|:
  Fly   868 IAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQ 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	11/59 (19%)
		PDZ_signaling	154..226	CDD:238492	18/71 (25%)
		PDZ_signaling	318..400	CDD:238492	23/100 (23%)
		PDZ_signaling	557..643	CDD:238492	28/91 (31%)
		PDZ_signaling	726..807	CDD:238492	23/85 (27%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	14/75 (19%)
		PDZ_signaling	183..254	CDD:238492	17/71 (24%)
		PDZ_signaling	278..375	CDD:238492	24/108 (22%)
		PDZ	496..>521	CDD:294084	6/27 (22%)
		PDZ_signaling	571..658	CDD:238492	33/105 (31%)
		PDZ_signaling	832..913	CDD:238492	21/75 (28%)
		PDZ_signaling	973..1055	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900