DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and dysc

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	166/879 - (18%)
Similarity:	278/879 - (31%)	Gaps:	344/879 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSS-------HSHSAPGSPDKSGGVGEE 123
            :.||.|.         .||....::..:|:..|...:|||       :|:......|::|.....
  Fly   209 MGQHASS---------NGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPA 264

  Fly   124 PRPQS---------QNSKGAGVADLY-----ATDYAQIQAIELVNDGTGLGFGIIGARNS--GVI 172
            ..|.|         :..:...|.:::     ....::.|.|:     .|.|..:.|.::|  ||.
  Fly   265 SSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQID-----HGFGICVKGGKDSGLGVY 324

  Fly   173 VKTILPGGVADKDGRLRSGDHILQIG-----DVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQS 232
            :..|....||::.| ||.||.||::.     .:| ||...::...:|: |...:.:.|..|...:
  Fly   325 ISRIEENSVAERAG-LRPGDTILEVNGTPFTSIN-HEEALKRCVQILK-SSRQISMTVRAPPTLN 386

  Fly   233 VPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTP-------------QTTT 284
            ...|.:...|     |:|   ||      :.::..|.:..::..|:..             ||.:
  Fly   387 STAPLHGFGP-----PSR---DP------MYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCS 437

  Fly   285 EDDR--------FVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEE 341
            ..||        ..|.|..|...| .|...|||..|            ...||:.|.|.|   |.
  Fly   438 WMDRHGRPASPPMEYGGRRSERRD-RIRRVELLIEP------------GQSLGLMIRGGV---EY 486

  Fly   342 LSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLK----------------- 389
            ..||||..|...|.||.|| :.:.|.|:||:|||....::.:||..||
  Fly   487 GLGIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPH 550

  Fly   390 ---------------------KSGQVVNL------------------------------------ 397
                                 :.||:..:
  Fly   551 SCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVA 615

  Fly   398 ----RLERYLRGPKFEQLQQAIAANDKL------------PSSA-----PGTPSRAPMPTP---- 437
                .|:.|.:.....::::.:...|:.            |.|.     .|.|:| .:|..
  Fly   616 VLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPAR-DLPVTADDL 679

  Fly   438 --VATTSSATTTPS---RSITRELEEEALPAPEAFMTTPPSV------------TTMTTTTLS-- 483
              :|.|..:.::.|   .::|...:..||..|...|:..|.:            :..::::||
  Fly   680 EIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPP 744

  Fly   484 -------------------------SFGAGK--------QLVAVRDSLD---------------G 500
                                     :.|:|:        ..:..|.:.|               |
  Fly   745 QQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRG 809

  Fly   501 STKIIPTEVVP-----------------------LADK-----------TEAKNSGVITRHKYYT 531
            |..::| |..|                       |.||           :..:|.|..|...:..
  Fly   810 SETLLP-EYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEH 873

  Fly   532 DPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSIL 596
            :|.:..|..            .::.:.|.:.|..    |||::||     |.....|...|.:|.
  Fly   874 NPNVVPDHR------------GNLHITVKKTKPI----LGIAIEG-----GANTKHPLPRIINIH 917

  Fly   597 PDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLK 661
            .:|.....|.|..|..:|||:|.::.|::|.||..::.|        |..||..:.:.|.....|
  Fly   918 ENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAE--------CFANREKAEITFLVVEAK 974

  Fly   662 KLSNNFEN--------------LLPATDRLVKAK 681
            |  :|.|.              .|||:|.|.:.|
  Fly   975 K--SNLEPKPTALIFLEAXHLLALPASDPLERQK 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	1/3 (33%)
		PDZ_signaling	154..226	CDD:238492	21/78 (27%)
		PDZ_signaling	318..400	CDD:238492	29/159 (18%)
		PDZ_signaling	557..643	CDD:238492	24/85 (28%)
		PDZ_signaling	726..807	CDD:238492
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	23/93 (25%)
		PDZ_signaling	466..543	CDD:238492	31/92 (34%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	5/79 (6%)
		PDZ_signaling	886..971	CDD:238492	28/101 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900