DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and GRID2IP

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	954	Identity:	201/954 - (21%)
Similarity:	316/954 - (33%)	Gaps:	261/954 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MQTAESLSTILGILQDPVFRT-------IVHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLS 88
            |.|..:.:|..|..:|..||.       ::.|....|      |....:.|.|..::|.|..|
Human     1 MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSS------AHAGGLRPGDQILEVEGLAV-- 57

  Fly    89 LNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELV 153
              ||     ...:|....:...|..|.   .:|..|.|......|:|.|       |....:...
Human    58 --GG-----LSRERLVRLARRCPRVPP---SLGVLPAPDGGPGPGSGPA-------APTTVLRAP 105

  Fly   154 NDGTGLGFG-----IIGARNSGVIVKTILPGGVADKDGR-----LRSGDHILQIGDVNLHEMVSE 208
            ..|.||..|     :.|.:.         |..|..:..|     .|..|.||  ||   .....|
Human   106 RCGRGLALGRELLRLAGRKR---------PDAVHRERRRKAQEFSRKVDEIL--GD---QPTAKE 156

  Fly   209 QVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVP----TRVLVDPAELERY--LISTGY 267
            ||.|.|:|.....|      |:..|.|...|| |..|..|    .|:.:......|:  ::|.|.
Human   157 QVFAALKQFAAEQR------VDDLVWTLTLAL-PREACGPLLDNLRIFIPKKHRARFDEVVSQGL 214

  Fly   268 ------------------------PEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEEL 308
                                    ||....|:.||.|....::..   ....|:|:..
Human   215 LGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPP---PRRASLLVGG------- 269

  Fly   309 LALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDG 373
            ||.|...:..|.:.|.....|.|:.|:       ..::::||.|||.|| :..::..|||:.::|
Human   270 LAGPGGARRTVRVYKGNKSFGFTLRGH-------GPVWIESVLPGSPAD-NAALKSGDRILFLNG 326

  Fly   374 QSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPV 438
            ..::..|:.:.|.:|:.||.:..|.:|        |.|....:.:|.|.|         |.|:..
Human   327 LDMRNCSHDKVVSMLQGSGAMPTLVVE--------EGLVPFASDSDSLDS---------PNPSSA 374

  Fly   439 ATT--------SSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVR 495
            .|:        .|:.....|:.:::||.         :.|||          ..:|..:.|.:..
Human   375 LTSLQWVAEILPSSIRVQGRTFSQQLEH---------LLTPP----------ERYGVCRALESFF 420

  Fly   496 DSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKY--------------------YT----DPELS 536
            ...:..|.|:  :|.|:.| |.||.  |:.:..|                    ||    :||..
Human   421 QHRNIDTLIV--DVYPVLD-TPAKQ--VLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE 480

  Fly   537 DDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPV 601
            .|.|:|...:.|.         .:.::..::....:..:|   :|.|....|     |..|:.|:
Human   481 LDLESEPTPEPQP---------RSSLRASSMCRRSLRSQG---LEAGLSCGP-----SECPEMPL 528

  Fly   602 G-VNGVLRSGD--ELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLP-----FSDD 658
            . :.|..::||  .|.|....:::...:.|:.:.|............::|.|...|     ....
Human   529 PLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPR 593

  Fly   659 TLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLTGLAMWS 723
            ||..:|...|.|||       :.....|.:.|..:...|.:...||....::.|.:|..|.....
Human   594 TLSGVSWPSERLLP-------SPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPD 651

  Fly   724 SQPQIIELVKGDRGLGFSILDYQDPLDPNDT---LIVIRSLVPGGVAQLDGRLIP---------- 775
            |.|.........|.   .:..:..|:...||   |.|:...:...|..:|..|.|
Human   652 SPPSPDPTRPPSRR---KLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFH 713

  Fly   776 GDRLLFVNSINLENASLDQAVQALKGASKGVVRIG-----------VAKPLPMTDNSLKACSNAS 829
            .|:..||.  |..:::.|....:.:|:|.....|.           ...|||..|  .|..|.:|
Human   714 DDQGSFVT--NERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHD--AKPSSRSS 774

  Fly   830 TTSEETLDA-------------QPSPPALPTVAPPAMPPSASMG 860
            ..|.....|             .|.||.||...|.| ||..|.|
Human   775 DGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCA-PPMLSRG 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	10/45 (22%)
		PDZ_signaling	154..226	CDD:238492	21/81 (26%)
		PDZ_signaling	318..400	CDD:238492	22/81 (27%)
		PDZ_signaling	557..643	CDD:238492	14/88 (16%)
		PDZ_signaling	726..807	CDD:238492	18/93 (19%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492	14/74 (19%)
		HN_L-delphilin-R1_like	133..212	CDD:259820	24/90 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		8/45 (18%)
		PDZ_signaling	278..353	CDD:238492	22/82 (27%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	18/102 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		15/68 (22%)
		FH2	820..1188	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900