DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and Fife

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001261340.1	Gene:	Fife / 38337	FlyBaseID:	FBgn0264606	Length:	1314	Species:	Drosophila melanogaster

Alignment Length:	1014	Identity:	205/1014 - (20%)
Similarity:	330/1014 - (32%)	Gaps:	291/1014 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SADISSALQQIEAVKKGIDESDDPKLQMQT---AESLSTILGILQDPVFRTIVHVQD-SLSELNA 64
            |.|....:..:||:::   ...|.||...|   |.|....|...:.|..|....|.. ||.||..
  Fly   193 STDSMLDVPVLEALQR---RHSDAKLGSSTQTLAPSNGAALAPPRSPELRRHSDVSPASLKELER 254

  Fly    65 QLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAP--GSPDKSGGVGEEPRPQ 127
            ||....||.|                              |.|:|.|  ..||.....| .|..:
  Fly   255 QLKGGRSMAP------------------------------SRSNSPPRGEGPDGQPPFG-APLSR 288

  Fly   128 SQNSKGAGVADLYATDYAQI------------QAIELVNDGTGLGFGIIGARNS----------- 169
            .|:.:|:.||..::.|....            .|:.|..||.|||...:..|.|
  Fly   289 MQSRRGSRVARQHSYDDDMKTGPVGGSMGGGGPALGLGADGAGLGIPTMPRRKSAYDVFAPGLTQ 353

  Fly   170 ----------------GVIVKTILPGGVA---------------DKDGRLRSGDHILQIGDVNLH 203
                            |::....|||...               |..|....|..:|.:.|...
  Fly   354 GGATPATQLQRSPGEGGIMPPIQLPGSRRPSFRVPHPSEDIQNDDSPGSPDKGSPVLTVDDDRR- 417

  Fly   204 EMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYP 268
                      :|:.|:.:              |..|:......:|.   |.|:.:...:.|...|
  Fly   418 ----------MRRRGSQL--------------PDIAMLQNRGALPA---VPPSSIPPPMASFTGP 455

  Fly   269 EIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKD-------AN 326
            .:  |...|...||:.:       ||...::..::|...:.|    .|.::.|::|       ..
  Fly   456 NL--EDLEAPRRQTSMD-------GEAIRIVIHDVDSGPICA----SKRRIILRRDPTDKAHRTR 507

  Fly   327 GLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKS 391
            |.|:.:.|.....:.....::....||.||:.:| ::..|:|:|.:|.||...|..:...::.::
  Fly   508 GFGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNG-LQQGDKILEWNGMSLIDRSFEEVCSIMDRT 571

  Fly   392 GQVVNLRLERYLRGPKF-------EQLQQAIAANDKLP-SSAPGTPSRAPMPTPVATTSSATTTP 448
            |.||.|.:|   ....|       |.|....|.....| .|..|......:..|..||..:..:|
  Fly   572 GDVVELLVE---HATDFRMCDLFDENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKSPASP 633

  Fly   449 SRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVV--- 510
            :|   |:|.:           ||..:            |.::||..|..:........:|:|
  Fly   634 TR---RKLPK-----------TPEQI------------AREKLVTGRVQIQVWYHAERSELVVSL 672

  Fly   511 ----PLADKTEAKNSGVITR--HKYYTDPELSDDA--ETEIIRKWQKIVGS-------------- 553
                .||.:.||...|.:..  .|....|:..|.:  :||:.|..|..:.:
  Fly   673 MAGDDLAPRDEAYGHGNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLM 737

  Fly   554 ----DVEV--IVAQIKKFAVGGLGISLEGTV-----------DVEGGREV----RPHHYIRSILP 597
                |:::  :|...:...:|...|.|:...           |.:|.|.:    .|     |:.|
  Fly   738 VRYIDIQLWDLVPHTESIFLGECSIELQQAFLDDQAIWCRLEDTKGLRGISISKSP-----SVSP 797

  Fly   598 DGPVGVNGVLRSGD--ELL--EVNGERLLGMNHLEVVAI---LKELPLDVRMVCGRNRNSSLLPF 655
            .|.:.......|||  .||  :.|.:|   .|..:|.:|   ...|..|...:.|..|.||....
  Fly   798 RGSIAAGAGAPSGDVTRLLRRDYNMQR---SNSDDVDSIGDGTSLLHPDHAWIAGSRRGSSQSET 859

  Fly   656 SDDTLKKLSNNFENLLPAT------DRLVKAKSDGSLAT----------AGSVADGD------SV 698
            .:..:.:|..:|...||.:      |.......:.::||          ..|||..|      |:
  Fly   860 MEVEVYQLGKDFSRSLPGSRRSSFQDAEKNRLEEDAMATPPTSYLVGRRRSSVARRDPDEILKSL 924

  Fly   699 AAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILD----YQDPLDPNDTLIV-- 757
            .|......:..|...|  ....|.|.:...:.|..|......|:||    :|..|.....|.:
  Fly   925 KAVRGELGRTMSLGTE--QHKRMGSRRASRVGLPSGPSSRKSSVLDLSQQHQQQLQQLQQLQLQQ 987

  Fly   758 ---IRSLVPGGVAQLDGRLIPGD-----RLLFVNSIN-LENASLDQAVQALKGASKGVVRIGVAK 813
               ::..:|.||...|......|     |..:..|:: |...|..||:..||.|:..   ..||:
  Fly   988 QQYLQQQLPMGVGNADTSPPSEDEDKRYRPRWKGSVSQLPPQSPKQALSRLKQAASA---SNVAQ 1049

  Fly   814 PLP-----MTDNSLKACSNASTTSEETLDAQPSPPALPT 847
            ...     :|.|.|:   ...::..:..::|.|||...|
  Fly  1050 DTQRQGQLLTTNPLQ---QRKSSMFQLGESQASPPTTTT 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	18/61 (30%)
		PDZ_signaling	154..226	CDD:238492	18/113 (16%)
		PDZ_signaling	318..400	CDD:238492	21/88 (24%)
		PDZ_signaling	557..643	CDD:238492	23/109 (21%)
		PDZ_signaling	726..807	CDD:238492	22/95 (23%)
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290
		PDZ_signaling	491..580	CDD:238492	21/89 (24%)
		DegQ	<526..577	CDD:223343	15/51 (29%)
		C2A_RIM1alpha	651..779	CDD:175997	21/127 (17%)
		C2	1163..1304	CDD:301316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900