DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Lnx1

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	148/700 - (21%)
Similarity:	239/700 - (34%)	Gaps:	285/700 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ISSALQQIEAVK----------KGIDESDD-------PKL---------------QMQTAESLS- 38
            |:.||..:...|          :|.|.|::       |:|               ::...||||
  Rat   228 INRALSALRRTKSGSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEITSIKINRVDPNESLSI 292

  Fly    39 TILGILQDPVFRTIV-HV-QDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEV------- 94
            .::|..:.|:...|: |: :|.:      :|:...:||        |:::|.:||.::
  Rat   293 RLVGGSETPLVHIIIQHIYRDGV------IARDGRLLP--------GDIILKVNGMDISNVPHNY 343

  Fly    95 -------------MYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQN---SKGAGVADLYATD 143
                         :....||:..|.| :|| :||..|     ||..|.:   :|.:....|
  Rat   344 AVRLLRQPCQVLRLTVLREQKFRSRS-NAP-APDSYG-----PRDDSFHVILNKSSPEEQL---- 397

  Fly   144 YAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSE 208
              .|:.:..|::             .||.:..:|.|||||:.|:|...|.:|.|...:|.....|
  Rat   398 --GIKLVRRVDE-------------PGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPE 447

  Fly   209 QVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPE-IFG 272
            ..|.:::.|...|.|||:|.|.|  |:|....|.|                  .||.|... :.|
  Rat   448 SAAHLIQASERRVHLVVSRQVRQ--PSPDIFQEAG------------------CISNGQQSPVSG 492

  Fly   273 ESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDAN-GLGITIAGYV 336
            |.||:|.|..|..                             ||: |.::||.| .||:|:.|..
  Rat   493 ERSTSSKPAATCH-----------------------------EKV-VSVQKDPNESLGMTVGGGA 527

  Fly   337 CEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLER 401
            ..:|....|:|.||.||......|||:..|.::.|:|..|...|..:||.:||
  Rat   528 SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILK------------ 580

  Fly   402 YLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELE-------EE 459
                                                        :|||..:.:.||       |:
  Rat   581 --------------------------------------------STPSSVVLKALEVKEQETQED 601

  Fly   460 ALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVI 524
            ..||                                 :||.:..:.|.
  Rat   602 CSPA---------------------------------ALDSNHNVTPP----------------- 616

  Fly   525 TRHKYYTDPELSDDAETEIIRKWQKI---VGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREV 586
                       .|.:.:.::  |.::   :.:..:||   :::...|.||..:.|..:...|.:
  Rat   617 -----------GDWSPSWVM--WLELPQYLYNCKDVI---LRRNTAGSLGFCIVGGYEEYSGNQ- 664

  Fly   587 RPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKEL 636
              ..:|:||:...|...:|.:|.||.||.|||....||.|..:..:||||
  Rat   665 --PFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMMHACLARMLKEL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	16/92 (17%)
		PDZ_signaling	154..226	CDD:238492	20/71 (28%)
		PDZ_signaling	318..400	CDD:238492	27/82 (33%)
		PDZ_signaling	557..643	CDD:238492	26/79 (33%)
		PDZ_signaling	726..807	CDD:238492
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	19/117 (16%)
		PDZ_signaling	276..360	CDD:238492	16/97 (16%)
		PDZ_signaling	384..464	CDD:238492	23/98 (23%)
		PDZ_signaling	506..589	CDD:238492	32/139 (23%)
		PDZ_signaling	637..721	CDD:238492	26/81 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910