DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Lnx2

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	152/755 - (20%)
Similarity:	242/755 - (32%)	Gaps:	289/755 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EQRSSSHSHS------------APG-SPDKSGGVG-----------------EEP---RPQSQNS 131
            |:|.:|.:|:            .|| ||.::..:|                 |:|   .|..:.|
  Rat   149 ERRKTSQAHTQIEGETGSTVIDPPGPSPPETDCLGTVPGERNSTPAPLPVWTEDPGLDNPAFEES 213

  Fly   132 KGA-GVADLYATDYAQIQAIEL--VNDGTGLGFGIIGARNS---GVIVKTILPGGVADKDGRLRS 190
            ..| .|....:....:|..||:  .|....||..|:|...:   .::::.:...|...:||||.:
  Rat   214 AAADSVQQPLSLPEGEITTIEIHRTNPYIQLGISIVGGNETPLINIVIQEVYRDGAIARDGRLLA 278

  Fly   191 GDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDP 255
            ||.|||:.:.::..:......|||.|..:.:.|.|.|
  Rat   279 GDQILQVNNCDISNVSHNYARAVLSQPCSTLHLTVLR---------------------------- 315

  Fly   256 AELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVE 320
               ||.         ||..:......:...|:.|                            ||.
  Rat   316 ---ERR---------FGSRANNHADGSAPRDEVF----------------------------QVL 340

  Fly   321 LKK--DANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQ 383
            |.|  .|..|||.:.    .:.:..|:|:..:..|..|...||:..|||::.::|..|:..:...
  Rat   341 LHKRDSAEQLGIKLV----RRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKQGTPEL 401

  Fly   384 AVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTP 448
            |..:::.||:.|||.:.|                        ||.|.                 |
  Rat   402 AAHIIQASGERVNLTIAR------------------------PGKPQ-----------------P 425

  Fly   449 SRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLA 513
            |.. :||     ..|..:....|||                      .|...|.|
  Rat   426 SNG-SRE-----AGAHSSNHAQPPS----------------------HSRPSSHK---------- 452

  Fly   514 DKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTV 578
            |.|..    |..:.|:.|                              :||.....||::
  Rat   453 DLTRC----VTCQEKHIT------------------------------VKKEPHESLGMT----- 478

  Fly   579 DVEGGREVRPHH---YIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDV 640
             |.|||..:...   ::.|:.|.|.:..:|.::.||.||.:||..|..::|.|.||:||......
  Rat   479 -VAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASP 542

  Fly   641 RMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLAT---AGSVADGDSVAAAA 702
            .::                ||.|.             |:...:.:.||   .|:.::.:..|:.:
  Rat   543 AVI----------------LKALE-------------VQIAEEAAQATEEQPGAFSENEYDASWS 578

  Fly   703 ASFSKLKSRSLEPLTGLAMWSSQPQI------IELVKGDRG-LGFSILDYQDPLDPNDTLIVIRS 760
            .|:              .||...|..      |.|.:...| .||||:...:....|.... |::
  Rat   579 PSW--------------VMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHSNQPFF-IKT 628

  Fly   761 LVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALK 800
            :|.|..|..||||..||.::.||.::....|....|..||
  Rat   629 IVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	20/74 (27%)
		PDZ_signaling	318..400	CDD:238492	25/83 (30%)
		PDZ_signaling	557..643	CDD:238492	25/88 (28%)
		PDZ_signaling	726..807	CDD:238492	25/82 (30%)
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	24/85 (28%)
		PDZ	335..421	CDD:214570	27/141 (19%)
		PDZ_signaling	462..538	CDD:238492	27/111 (24%)
		PDZ_signaling	595..679	CDD:238492	24/75 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910