DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and CG43707

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001260005.1	Gene:	CG43707 / 33601	FlyBaseID:	FBgn0263846	Length:	2021	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	183/984 - (18%)
Similarity:	306/984 - (31%)	Gaps:	297/984 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSMLPNDF 77
            ::|..|..::.||:.:.:.:.:|......|          ..:.|...:|...|.:....|..
  Fly   732 EVEVRKVELEPSDEEEDEDEVSEPEEEDDG----------EEIDDDEQKLETDLQEDEEPLYE-- 784

  Fly    78 DIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVA----D 138
            :|...|..|:..:..|   |..::||.....|.....|......|.|.|..........:    :
  Fly   785 NITPCGCRVVPTSDAE---DIQDKRSQFRKRSVSLDDDYEAKASETPTPTGLRLPSTPASPCRDE 846

  Fly   139 LYATDYAQIQAIELVNDGT-----GLGFGIIGARNSGVIVKTILPGGVAD-KDGRLRSGDHILQI 197
            |.|.......:..|.||.|     |:.       |...:  |:|.....| .||...|
  Fly   847 LLANVSTYPSSDSLANDNTRDHSDGIW-------NESQV--TVLTAEQRDISDGSYSS------- 895

  Fly   198 GDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPT---------PQYALE--PGTAVVPTRV 251
               ||          :|..|.....|::......||.|         |.|.|:  |.....||..
  Fly   896 ---NL----------LLTPSSKRKNLLLQHQQRSSVDTDALDFEEQSPTYGLQTLPKIIKTPTPT 947

  Fly   252 LVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEK 316
            ...|         |....:....:.|.||.|....|..:    :|.|  |...:....::|:..:
  Fly   948 TSRP---------TSTQPMMPPPAIAVTPSTNQILDSCI----SSPL--PKRSMVARGSVPDARQ 997

  Fly   317 LQV------ELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQS 375
            |..      :...||:.|.:..|.| ....::|.....:....:..|.|.|..|:.       ||
  Fly   998 LMFTSGATKQRHSDASFLPMGAADY-ARSADISECSTNTDEYATCTDTSKRTPVST-------QS 1054

  Fly   376 LQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFE------QLQQAIAANDKLPSSAPGTPSRAPM 434
            .|                     ||:...|..||      .:::.:..:|:.......|.::|.:
  Fly  1055 SQ---------------------LEKTHAGSSFESASSLYSMREDLLQHDEKERDKQTTLTKAQL 1098

  Fly   435 PTPVATTSSAT-TTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSL 498
            .:|:.:.:..| .:||.||:......:.|...|.:.: |:..::..|..||..:..::
  Fly  1099 KSPIGSVAELTRKSPSHSISSTTSSGSCPVLGAAIKS-PAKESLPQTVASSVTSQMKV------- 1155

  Fly   499 DGSTKIIPTEVVPLADK-TEAKNSGV-ITRHKYYTDPELSDDAE-----------TEIIRKWQK- 549
             .|.:.||..|.|..|. :|.:.|.| .:...||..|...||.|           .|..||.:|
  Fly  1156 -SSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPHEEDDEEQGTRSKARRLRQEDERKRRKT 1219

  Fly   550 -----IVGSDVEVIVAQIKKFAVGGLGI-----SLEGTVDVEGG-----REVRP--HHYIRSILP 597
                 |...::..:.:.||| ..|...|     |:.||:| .|.     :..||  ...:|....
  Fly  1220 SMKLDIEKENMRALTSPIKK-PTGSSKITSPEQSISGTMD-NGSSPSKMKRFRPKIRRQLRKSSR 1282

  Fly   598 DGPVGVNGVLR-------------SGDELLEVNGERLLGMNHLEVVAILKELPLDVRM----VCG 645
            :..:....|.|             |||                      .||.||..|    |.|
  Fly  1283 EDVLAAAAVRRSRATPTIFGLSSGSGD----------------------TELLLDASMSTGAVAG 1325

  Fly   646 RNRNSSLLPFSDDTLKKLSNNFENLLPATDRLV---KAKSDGSLATAGSV-------ADGDSVAA 700
            ...::.....:..:..||..:..::....:.:|   .||...|.||..|:       ..|....:
  Fly  1326 TTTSAVTSVSAPSSASKLPTSESSVTTQPEAVVAPLPAKKPHSCATPTSLLSPKLPTTSGTQSKS 1390

  Fly   701 AAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGG 765
            .:.:| :||::|:|.|                                          ||:.||.
  Fly  1391 TSDTF-QLKAKSIESL------------------------------------------RSVSPGS 1412

  Fly   766 ----VAQLDGRLIPGDRLLFVN-SINLENASLDQAVQALKG---ASKGVVRIGVAKP------LP 816
                .::.||....|::....: ...:|.......:..|.|   .|...:...:.||      .|
  Fly  1413 DSVFYSEADGNAASGEQSHCHHCGKEMEGKQQSNTISELAGDSVESIPYIEQDIVKPPSDFADSP 1477

  Fly   817 MTDNSLKAC------------------SNASTTSEETLDAQPSP----PALPTVAPPAMPPSASM 859
            :|..:.:..                  .....|.:|.:.|:...    |:||..  |.:.|:
  Fly  1478 VTTKTTQRLYKKMDKRFRSEERYHGERGRHYKTRQENIRAKSEERGRIPSLPNT--PVLRPA--- 1537

  Fly   860 GAEPDLIPD 868
            |:.|.::||
  Fly  1538 GSSPCVLPD 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	9/56 (16%)
		PDZ_signaling	154..226	CDD:238492	16/77 (21%)
		PDZ_signaling	318..400	CDD:238492	13/87 (15%)
		PDZ_signaling	557..643	CDD:238492	23/114 (20%)
		PDZ_signaling	726..807	CDD:238492	11/88 (13%)
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	90/468 (19%)
		PDZ_signaling	1702..1775	CDD:238492
		PH	1792..1894	CDD:278594
		PH-like	1792..1893	CDD:302622
		PH-like	1911..2011	CDD:302622
		PH	1921..2014	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900