DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Pard3b

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	1072	Identity:	234/1072 - (21%)
Similarity:	357/1072 - (33%)	Gaps:	398/1072 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPS-----MLPND- 76
            ::|:.:.::..:::...|.|.......|| |||              |..:.||     :||.:
  Rat   244 QEGLFQENECIVKINNVELLDKTFAQAQD-VFR--------------QAMKSPSVVLHVLLPQNR 293

  Fly    77 --FDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSG-----------GVGEEPRPQS 128
              ::..|.|.|.:          |....|:|.:.:.|.:..|:|           ..||| .|..
  Rat   294 EQYEKSVIGQLNI----------FGNNDSASRTKAPPPTRGKAGLKAVNPTRANSPEGEE-SPSP 347

  Fly   129 QNSKGAGVADL---------------YATDYAQIQAIELVNDGTGLGFGIIGARNSG------VI 172
            |.||...|..|               .:...|:...|:|.....||||.:: .|:|.      :.
  Rat   348 QQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVV-TRDSSIHGPGPIF 411

  Fly   173 VKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLR--QSGTHVRLVVARPVEQSVPT 235
            ||.|||.|.|.|||||:|||.||::...::.....|::.|:||  :.|..|.||:||
  Rat   412 VKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIAR-------- 468

  Fly   236 PQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLID 300
                 :.|:.:        |.||:      |.|:.:.
  Rat   469 -----QEGSFL--------PRELK------GEPDCYA---------------------------- 486

  Fly   301 PNIDLEELLALPETEKLQVEL---KKDANGLGITIAGYVCEKEELS-GIFVKSVSPGSAADLSGR 361
                    |:|..:|:|.:|:   ...:.|||:::.|....:.... |||:||:..|.||...||
  Rat   487 --------LSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543

  Fly   362 IRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQ-----------VVNLRLER---------YLRGP 406
            :|:||::|.|:|::|.|.|||:|:|.|::|..           |:..||||         .|..|
  Rat   544 LRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRLERPLEEISECGALSRP 608

  Fly   407 KFEQLQQAIAAN-----------------DK-----LPS------SAPGTPSRAPMP-------- 435
            .||..|:|::|:                 ||     |||      ..|  ||..|.|
  Rat   609 CFENCQEALSASRRNDSSLLYPCGTYSPQDKRKDLLLPSDGWAENEVP--PSPPPHPSLEWGLED 671

  Fly   436 -----------------------TPVATTSSATTTPSRSITRELEEEALPA-------------- 463
                                   |||....|.....|:|:....:|..:.:
  Rat   672 FSHSSRVDSTGYFPDQHVNFRIVTPVGQPESINLKASKSMDLVPDESKVQSLADRRSDSPGKDFG 736

  Fly   464 PEAFMTTPPSVTTMTTTTL-----------------------SSFGAGKQLVAVRDSLDGSTKII 505
            |...:....|:.::.|...                       .||.|     |:..|.||..:
  Rat   737 PTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRA-----AIDKSYDGPEE-- 794

  Fly   506 PTEVVPLADKTEAKNSGVITRHKYYT----------DPELSDDAET------------------- 541
             .|...|:||:.         |..:|          :||| ||.|.
  Rat   795 -AEADGLSDKSS---------HSGHTALNCESAPQGNPEL-DDVENKAKNVKKTKEKEKKKGKGK 848

  Fly   542 -EIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVG--- 602
             ::..|.||....|.|      :|....|.|..|      ..|::           .|..||
  Rat   849 MKVKEKKQKEEHEDTE------RKMKRKGFGAML------RFGKK-----------KDDKVGKTE 890

  Fly   603 VNGVLRSG----DELLEVNGER-LLGMNHLEVVAILKELP----LDVRMVCGRNRNSSLLPFSDD 658
            ..|..:||    :||..:..|| .:|..|.|    |:|..    :|...|.    ...:....||
  Rat   891 QKGTQKSGHPGEEELERMKEERERIGAKHQE----LREKQARGLVDYATVA----TGPVHDIDDD 947

  Fly   659 TLK---KLSNNFENLLPATD-RLVKAKSDGSLATAGSVADG-----DSVAAAAASFSKLKSRSLE 714
            .:.   ...|:|..  |.|. .:.::.|.....|.|...||     |.:....|..:|.......
  Rat   948 EMDPNYARVNHFRE--PCTSANVFRSPSPPRAGTLGYPRDGRPLSPDHLEGLYAKVNKPYHPPAL 1010

  Fly   715 PLTGLAMWSSQPQIIELVK---GDRGLGFSILDYQDPLD-PND-TLIVIRSLVPGGVAQLDGRLI 774
            ..:|..|..:..:|.:|.|   ..|..||.:.:.::.:. |:| .|..:....|.|.|.
  Rat  1011 ADSGRPMAGTTDRIQKLRKEYYQARREGFLLYEDEEGVTRPSDYDLHWVSGKGPDGSAH------ 1069

  Fly   775 PGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLDAQ 839
                       ||....:::...:|.       |.|.|.|:.....|.:...|     |..|...
  Rat  1070 -----------NLRFEGMERQYASLP-------RGGSADPVDYLTASPRGRYN-----ERELPYY 1111

  Fly   840 PSPPALPTVAPPAMPPSASMGAEPDL-IPDWR 870
            |.|       .|...|..|....||| :.|.|
  Rat  1112 PGP-------HPVHSPRGSYPRPPDLRVTDLR 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	9/51 (18%)
		PDZ_signaling	154..226	CDD:238492	31/79 (39%)
		PDZ_signaling	318..400	CDD:238492	32/96 (33%)
		PDZ_signaling	557..643	CDD:238492	21/97 (22%)
		PDZ_signaling	726..807	CDD:238492	15/85 (18%)
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492	11/58 (19%)
		PDZ	380..469	CDD:214570	35/102 (34%)
		PDZ_signaling	501..589	CDD:238492	30/87 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900