DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Grip2

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_006506166.1	Gene:	Grip2 / 243547	MGIID:	2681173	Length:	1049	Species:	Mus musculus

Alignment Length:	893	Identity:	204/893 - (22%)
Similarity:	314/893 - (35%)	Gaps:	254/893 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 FDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVAD--------LYATDYAQIQAIELV- 153
            |..:|:..|...|        |...:..|.|:..|....||        ....::..|..:||:
Mouse     9 FSPRRALGHWQEA--------GTARDDGPYSKGGKDTAGADGALVCRRQSIPEEFRGITMVELIK 65

  Fly   154 NDGTGLGFGIIGA--RNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQ 216
            .:|:.||..|.|.  ::....|..:.|||:|.:...|..||:|..:..::|..:..:::..:|:.
Mouse    66 REGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSVNGIHLTRLRHDEIITLLKN 130

  Fly   217 SGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVD--------------------------- 254
            .|..|.|    .||..:|.|  |.|....::...|.|.
Mouse   131 VGERVVL----EVEYELPPP--APENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRPLV 189

  Fly   255 --------PAELE-------RYLISTGYPEIFGESSTA-STPQTTTEDDRFVYRGETSMLIDPNI 303
                    ||:.|       |.|...|.|......:|| :|.|..:.:..|
Mouse   190 LTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALF-------------- 240

  Fly   304 DLEELLALPET-----EKLQVELKK---DANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSG 360
            .:|..:|.|:|     ..|.||:.|   .|.|:.:|...:    .....|.:..:.|.|..|.||
Mouse   241 QVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSH----RNKPAITIDRIKPASVVDRSG 301

  Fly   361 RIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRL------ERYLRGP---KFEQLQQAIA 416
            .:...|.|:.:||.|.:..|..:|.:||....:.|.|.:      .|.|:.|   :.::.:|...
Mouse   302 ALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPSPQSRRPLKPPEAVRIQRSEQLHR 366

  Fly   417 ANDKLPSSAPGTPSRAPMPTPVA----TTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTM 477
            .:...||.....||....||..|    .:.|.::||..|.|.   ..|.|...| .|.|....:.
Mouse   367 WDPSAPSCHSPRPSHCRAPTWAAGGPDQSRSVSSTPFSSPTM---NPAFPCANA-STLPRGPMSP 427

  Fly   478 TTTTLSSFGAGKQLVAVRD-----SLDGST-----KIIPTEVVPLADKTEAKNSGVITRHKYYTD 532
            .||      ||::....::     ||..||     :|:.||.      ||....|         |
Mouse   428 RTT------AGRRRQRRKEHRSSLSLASSTVGPGGQIVHTET------TEVVLCG---------D 471

  Fly   533 PELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILP 597
            |                                 :.|.|:.|:|.:.........|  .:|.|.|
Mouse   472 P---------------------------------LSGFGLQLQGGIFATETLSSPP--LVRFIEP 501

  Fly   598 DGPVGVNGVLRSGDELLEVNG-----------ERLLGMNHLEVVAILKELPLDVRMVCGRNRNSS 651
            |.|....|:|:.||.:|.:||           .:||....|....:| |:..||.        .|
Mouse   502 DSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVL-EIEFDVA--------ES 557

  Fly   652 LLPFSDDTLKKLSNNFENLLPATDRLVKAK-------SD---GSLA-TAGSVADGDSVAA----- 700
            ::|.|.....||.......|..|......|       ||   ||:| ..|::..||.:.|
Mouse   558 VIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIR 622

  Fly   701 --------------AAASFSKLKSRSLEPLTGLAMWSSQPQ--------IIELVKGDRGLGFSIL 743
                          ......|||.|..|.       :|..|        .:||.:....||.:|.
Mouse   623 LDHCPMEDAVQILRQCEDLVKLKIRKDED-------NSDEQESSGAVSYTVELKRYGGPLGITIS 680

  Fly   744 DYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGV-- 806
            ..::|.||    |:|..|...|:|:..|.:..|||:|.:||::|:...|.:|:..|:.|.:.|
Mouse   681 GTEEPFDP----IIISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTL 741

  Fly   807 -VRIGVAKP-LPMTDNSLKACSNASTTSEETLD----AQPSPPALPTV 848
             ::..:.:| ||....||...|:......|.|.    |....||:|:|
Mouse   742 KIKKQLDRPLLPRQSGSLSEASDVDEDPPEALKGGLLATRFSPAVPSV 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	19/73 (26%)
		PDZ_signaling	318..400	CDD:238492	23/90 (26%)
		PDZ_signaling	557..643	CDD:238492	24/96 (25%)
		PDZ_signaling	726..807	CDD:238492	27/91 (30%)
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492	22/85 (26%)
		PDZ_signaling	160..243	CDD:238492	13/96 (14%)
		PDZ_signaling	258..341	CDD:238492	24/86 (28%)
		PDZ_signaling	463..551	CDD:238492	27/138 (20%)
		PDZ_signaling	564..647	CDD:238492	17/82 (21%)
		PDZ_signaling	664..744	CDD:238492	26/83 (31%)
		PDZ_signaling	947..1026	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810