DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and PDZD2

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	901	Identity:	199/901 - (22%)
Similarity:	334/901 - (37%)	Gaps:	259/901 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLS---LNGGEVMYDFDEQRSSSHSHSA-PGS 113
            |.::|.:..||.||.         ..:||:|...|:   .||| .:|....:|....:||. .|:
Human   136 VRLRDEILSLNGQLM---------VGVDVSGASYLAEQCWNGG-FIYLIMLRRFKHKAHSTYNGN 190

  Fly   114 PDKSGGVGEEP----------------------RPQS----QNSKGAGVADLYATDYAQIQAIEL 152
            ...|...||.|                      ||.:    :.|||:.             ..|:
Human   191 SSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSA-------------GCEV 242

  Fly   153 VNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQI--GDVNLHEMVSEQVAAVLR 215
            .:|.:                 |.|..|   .|..|.:| |:.|:  |..:|.|:
Human   243 SSDPS-----------------TELENG---PDPELGNG-HVFQLENGPDSLKEV---------- 276

  Fly   216 QSGTHV-RLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTAST 279
             :|.|: |..|.|..|..:|                                         ....
Human   277 -AGPHLERSEVDRGTEHRIP-----------------------------------------KTDA 299

  Fly   280 PQTTTEDD-RFVYRGETSMLIDPNIDLEELLALPETEKL-QVELKKDANGLGITIAGYVCEKEEL 342
            |.||:.|. ||...|:|      :....:.||..|..:: ::||.|:::||||.::|....|...
Human   300 PLTTSNDKRRFSKGGKT------DFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSP 358

  Fly   343 SGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPK 407
            ..|.|..|..|.||...||:.:.|.::.::|..|.|.|:.:||.:|:.:..:|.|.:
Human   359 HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV-------- 415

  Fly   408 FEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEE-------EALPAPE 465
               ..:..:|.|.|..::...|.   :.:.|...||.|....:....|.:|       .|:|..:
Human   416 ---ASKENSAEDLLRLTSKSLPD---LTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTD 474

  Fly   466 AFMTTPPSV--TTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPT-----EVV-----PLADKTEA 518
                .|..|  ...:...|.|...|...:.::..|.|....:.:     |::     |.....|.
Human   475 ----EPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEV 535

  Fly   519 KNSGVITRHKYYTDPELSDDA----ETEIIRK-------------WQKIVGSDVEVIVAQIKKFA 566
            ...|     :.::.|:|.|.:    |..|::|             |:.|..|.:.:|  .:.|..
Human   536 SRDG-----RKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISII--GLYKEK 593

  Fly   567 VGGLGISLEGTVD-VEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVV 630
            ..|||.|:.|..| :.|...:    ::::|.|:|....:|.|:.|||:|:|||..:.|:...|.:
Human   594 GKGLGFSIAGGRDCIRGQMGI----FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654

  Fly   631 AILKELPLDVRMVCGRNR--NSSLLPFSDDT--LKKLSNNFENLLPATDRLVKAKSDGSLATAGS 691
            ...|::...:.::..|.:  :.||.|.|..|  .:..|.||.                   |:|.
Human   655 HTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFN-------------------TSGG 700

  Fly   692 VADGDSVAAAAASFSKL----KSR-------SLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDY 745
            .:.|.|...:::|..:.    |.|       :.||..||                 |:|...|
Human   701 ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGL-----------------GIGACCL-- 746

  Fly   746 QDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIG 810
              .|:.:...|.|.||.||.||:::..|..||::|.|||:|:.:|:|.:....|.....|.||:.
Human   747 --ALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLV 809

  Fly   811 VAK-PLPMTDNSLKACSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMGAEPDL 865
            :.: |.|...........|.:|.:|:.:|..||.....:..|::....|:.:|.:|
Human   810 IGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESEL 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	6/16 (38%)
		PDZ_signaling	154..226	CDD:238492	15/74 (20%)
		PDZ_signaling	318..400	CDD:238492	27/81 (33%)
		PDZ_signaling	557..643	CDD:238492	24/86 (28%)
		PDZ_signaling	726..807	CDD:238492	24/80 (30%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	27/91 (30%)
		PDZ_signaling	589..670	CDD:238492	23/84 (27%)
		PDZ_signaling	726..810	CDD:238492	30/104 (29%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860