Protein Alignment Patj and frm-5.1

DIOPT Version :10

• Sequence 1: NP_477342.1
• Gene: Patj / 44100
• FlyBaseID: FBgn0067864
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001408266.1
• Gene: frm-5.1 / 176822
• WormBaseID: WBGene00001492
• Length: 1567
• Species: Caenorhabditis elegans
• Alignment Length: 876
• Identity: 189/876 - (21%)
• Similarity: 304/876 - (34%)
• Gaps: 284/876 - (32%)

  Fly    55 VQDSLSELNAQLA----------------QHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRS 103
            :::.|:||:...|                :||     ||             |..|...|..:.:
 Worm   855 LKNILAELHGHYAGTRISEAKHKYIQICQRHP-----DF-------------GAHVHRVFRTKPT 901

  Fly   104 SSHSHSAPGSPDKSGG--VGEEPRP----QSQN----------SKGAGVADLYATD-YAQIQAIE 151
            |:|. ::|..||....  :|..||.    :.||          ::..|..::.|.. :.|.|.::
 Worm   902 SAHG-ASPFDPDTGSSLWIGIMPRGISIYEQQNHHIPNKYMSIARQGGAREVIAEHVWPQTQTLQ 965

  Fly   152 LVNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQ 216
            .  |........:||.:. .|..|..      .|...:|...:......:...|...|..:.||
 Worm   966 F--DKKRFVIVAVGAHDE-QIESTFY------TDHHSKSSYFVRFAASQHRWMMKMRQWKSTLR- 1020

  Fly   217 SGTHVRLVVARP---VE-QSVPTP--QYALEPGTAVVPTRVLVD-----------------PAEL 258
               |...:.|.|   || |::|..  :..||......|.....|                 ||||
 Worm  1021 ---HENTIQAMPDVIVEGQTIPPAPIRQGLEESPPSTPLLASADQIFAKMSVSQEKPAANRPAEL 1082

  Fly   259 ERYLISTGYPEIFGESSTASTPQTTTEDDRFV--YRGETSMLIDP----NIDLEELLALPETEKL 317
                     |.....|..|:  |..|.|:..|  .:.|....:|.    |:       .|...:.
 Worm  1083 ---------PPPAPSSKFAA--QYDTVDEGIVCDSQAENFERVDSTDNGNV-------TPRGMQF 1129

  Fly   318 QVELKKD-ANGLGITIA-GYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYS 380
            .:.|.|| |||||:|:. |.:   ..:.|::||.|:...|...:| :.|.|||::|..:|::|:.
 Worm  1130 DILLVKDPANGLGLTLVDGNL---NGVPGVYVKLVADNGAGMKAG-VCVGDRIVQVGTESMEGHD 1190

  Fly   381 NHQAVELLKKSGQ---VVNLRLERYLRGPKFEQLQQ-AIAANDKLPSSAPGTPSRAPMPTPVATT 441
            ...||||:::.||   :|..||:..:|..|....:. |.|...|..:|:.|....||     ..|
 Worm  1191 RLHAVELVRRCGQRVPMVIARLDGLIRHQKDVSAEMLASAGRKKSFTSSSGDLLNAP-----NRT 1250

  Fly   442 SSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGA-GKQLVAVRDSLDGSTKI- 504
            :..:.||             |||.       .........:|.||| |..|    .:|||...|
 Worm  1251 NGQSRTP-------------PAPR-------KAANRRQRAVSDFGAIGDAL----PTLDGDNLIN 1291

  Fly   505 --------------------IPTEVVPLADK--------TEAK------NSGVITRHKY--YTDP 533
                                :||..:...|:        .|:|      .||.:.:::|  .::.
 Worm  1292 IKAISGLHLDESDEEKGEYRLPTTSMYAFDRDDDLQASIKESKKPAPEPKSGELRKYRYARRSNL 1356

  Fly   534 ELSDDAETEIIRKWQKIVGSDVE--------VIVAQIKKFAVGGLGI---SLEGTVDVEGGREVR 587
            |::::.|.|.:.      .||.:        ||..::.:...|.||:   ||.|.|.::.
 Worm  1357 EIAEEIEEEAVE------SSDDDGQIDEGKRVIDVELDRNENGSLGVQIASLSGRVCIKQ----- 1410

  Fly   588 PHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSL 652
                    |...|...:..:|.||.||.|||..:.|..|.||||:|:
 Worm  1411 --------LTSEPAISHPDIRVGDVLLYVNGIAVEGKVHQEVVAMLR------------------ 1449

  Fly   653 LPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLT 717
                        ...:.::....|...|.||...|::      .|.:|...|...||    :|:.
 Worm  1450 ------------GGGDRVVLGVQRPPPAYSDQHHASS------TSASAPLISVMLLK----KPMA 1492

  Fly   718 GLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFV 782
            .|.        :.|.|.....|                |.||::.....|..:|.|..||||:.:
 Worm  1493 TLG--------LSLAKRTMSDG----------------IFIRNIAQDSAASSEGTLRVGDRLVSL 1533

  Fly   783 NSINLENASLDQAVQALKGASKGVVRIGVAK 813
            :...::..:....::.|| ..:|.|:|.|.:
 Worm  1534 DGEPVDGFTPATILEKLK-LVQGPVQITVTR 1563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:470651	4/30 (13%)
		PDZ2_MUPP1-like	148..227	CDD:467155	13/78 (17%)
		PDZ3_MUPP1-like	315..401	CDD:467253	32/90 (36%)
		PDZ4_MUPP1-like	556..646	CDD:467156	26/100 (26%)
		PDZ5_MUPP1-like	719..816	CDD:467157	20/95 (21%)
frm-5.1	NP_001408266.1	Protein Kinases, catalytic domain	9..164	CDD:473864
		B41	688..893	CDD:214604	9/55 (16%)
		PH-like	889..1018	CDD:473070	26/138 (19%)
		PDZ_canonical	1130..1210	CDD:467153	30/83 (36%)
		PDZ	1381..1463	CDD:214570	27/124 (22%)
		PDZ_canonical	1486..1562	CDD:467153	22/104 (21%)