DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and mpz-1

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001364655.1	Gene:	mpz-1 / 174657	WormBaseID:	WBGene00003404	Length:	2422	Species:	Caenorhabditis elegans

Alignment Length:	1059	Identity:	295/1059 - (27%)
Similarity:	433/1059 - (40%)	Gaps:	361/1059 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDS------------- 58
            |...|:::::.|:|.|..:|          :..|..||:||:|:.:.|...|
Worm    39 IREVLRELKSRKEGGDVKED----------IERIERILKDPLFKQLSHQPTSSPETFKSDNRRNS 93

  Fly    59 --------------LSELNAQLAQHPSMLPNDFDIDVAGNLVL---------------------- 87
                          .||:...|.|:..:|....|..:...:||
Worm    94 AAEKRVVEISKRIESSEIRKNLKQNQKLLFIYVDAKLVDPVVLETKEKSSRLLVVGPKDVKNRST 158

  Fly    88 -SLNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVAD------------- 138
             .|..|:.:...|    :|...|.|.:|..:        ..|.::|||....
Worm   159 GKLRIGDCVVAID----ASGGSSVPSAPSST--------VSSDDTKGAAATTTARFAIHNQTIGK 211

  Fly   139 ----------------------------LYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKT 175
                                        :.:.|:.|::.|.|..:..||||||:|..::||:|||
Worm   212 SEFETACHKSISAKQHLVVGVIREATPMVLSGDWTQVEVIHLNTETGGLGFGIVGGTSTGVVVKT 276

  Fly   176 ILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPV---EQSVPTPQ 237
            ||||..|||||||:.||||||||::|.|.|.|:|||.:||.....|.::|.||:   ::.:.||:
Worm   277 ILPGSPADKDGRLQPGDHILQIGNINSHGMSSQQVATILRHQHPTVDMIVGRPIAYADKPIDTPE 341

  Fly   238 ------------------------------------YALEPGTAVV--------------PTRVL 252
                                                ..|.|..:.|              ||...
Worm   342 CFTLATKAALCATTLEEALQRQMATSVPSTTANQTPNTLSPSISCVPIEEEKEEKEPEPEPTTSK 406

  Fly   253 VDPAELERYLIST-----------GY--------------------------------------- 267
            ..|.::..||..|           .|
Worm   407 EQPIKITTYLPDTIDIRKPCDCAPNYNRRDKRKSSCDDGEHGDGDGGGGCKKTKEDHQEEENEID 471

  Fly   268 -PEIFGESSTASTPQTTTEDDRFVYRG------ETSMLIDPNIDLEELLALPET----------- 314
             .:..||...:.|.:|...|:..|...      ..|..|...|.|:.|..:..|
Worm   472 SKDELGEMVRSPTVETGQSDENSVVTSVSRSSKRNSNSITSRISLKSLQEMALTVFLRENWESTK 536

  Fly   315 -EKLQVELKKD-ANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQ 377
             |.:.|.|.:| |.|||||:||||.:|||:.||||||:.|.|||..||.|:|:|.|:||:|.:|:
Worm   537 FELIDVALHRDPALGLGITVAGYVHKKEEIGGIFVKSLVPRSAASSSGVIKVHDLILEVNGTTLE 601

  Fly   378 GYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTS 442
            ..|:..:|..|.|||..|.|:|.|:                              |:.:|.|
Worm   602 HMSHADSVRTLVKSGDQVKLKLVRF------------------------------PLSSPQA--- 633

  Fly   443 SATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPT 507
                                                           |.:.:....:..|::|
Worm   634 -----------------------------------------------QCLKMLQQQETETQVI-- 649

  Fly   508 EVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIK---KFAVGG 569
                                    |.:||:   .:::::|:..:|.|:|:|.|.:|   :...||
Worm   650 ------------------------DVKLSN---PDLVKEWKSRIGDDIEIIAAVVKPDRQSVDGG 687

  Fly   570 LGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEV----- 629
            |||||||||||..|.::.|||||.||..||||....||::|||||:||...|.|.:|:.|
Worm   688 LGISLEGTVDVLNGAQLCPHHYIESIRQDGPVAKTKVLQAGDELLQVNHSPLYGESHVTVRQALT 752

  Fly   630 VAILKELPLDVRMVCGRNRNSSLLPFSDDTL-KKLSNNFENLLPATDRLVKAKSDGSLATAGSVA 693
            .|:....|  |.::..| |:..|..|...|. |:|..:|..|....:.:||||||..|.:..:
Worm   753 RAVHSGAP--VTLIVAR-RSQHLHVFEPTTYEKQLPLSFPFLAANQETVVKAKSDIDLTSTRA-- 812

  Fly   694 DGDSVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVI 758
              ::.........:|:|:|||...|||:|:..|.:|.|.|..|||||||:||:||...::::||:
Worm   813 --ETTHLLQRVSRRLRSKSLENFHGLAVWNCVPLVIHLCKDSRGLGFSIVDYKDPTHRDESVIVV 875

  Fly   759 RSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLK 823
            :|||||||||.|||::|||||||||:.:|.|:||::||..||.|..|.||:|:|||:|:..:...
Worm   876 QSLVPGGVAQADGRVVPGDRLLFVNNHDLSNSSLERAVAVLKAARMGPVRLGLAKPIPVDQSQFT 940

  Fly   824 ACSNASTTSEETLDAQPSP 842
            :.|...:.||..|....||
Worm   941 SHSPLCSRSERLLARGRSP 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	16/84 (19%)
		PDZ_signaling	154..226	CDD:238492	41/71 (58%)
		PDZ_signaling	318..400	CDD:238492	44/82 (54%)
		PDZ_signaling	557..643	CDD:238492	44/93 (47%)
		PDZ_signaling	726..807	CDD:238492	48/80 (60%)
mpz-1	NP_001364655.1	PDZ_signaling	<271..326	CDD:238492	34/54 (63%)
		PDZ_signaling	539..624	CDD:238492	44/84 (52%)
		PDZ_signaling	685..766	CDD:238492	41/82 (50%)
		PDZ_signaling	843..926	CDD:238492	49/82 (60%)
		PDZ	1050..1124	CDD:214570
		PDZ_signaling	1475..1569	CDD:238492
		PDZ	1827..1912	CDD:214570
		PDZ	1988..2073	CDD:214570
		PDZ_signaling	2089..2169	CDD:238492
		PDZ_signaling	2341..2414	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167057
Domainoid	1	1.000	100	1.000	Domainoid score	I4418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		oto19622
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4712
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870