DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Patj and Il16

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001347016.1	Gene:	Il16 / 16170	MGIID:	1270855	Length:	1424	Species:	Mus musculus

Alignment Length:	1031	Identity:	214/1031 - (20%)
Similarity:	346/1031 - (33%)	Gaps:	332/1031 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSML 73
            |::|..:..:.|:  |:.|.|.:.:..:.....|..:....|.:..:::|.|..:.:.:..|...
Mouse   161 SSMQLADTFEAGL--SNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQ 223

  Fly    74 PNDFDIDVA--------GNLVLSLNGGEVMYDFD-EQRSSSHSHSAPGSPDKSG----------- 118
            .:.|....|        ...|...:.||:  ||. .::|::.:...|.|...:.
Mouse   224 SSSFLFPKACHQRTRSNSTSVNPYSAGEI--DFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPI 286

  Fly   119 -GVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGARNS-----GVIVKTIL 177
             |.....|..|....|.....|.|:..:.|  :.:.....||||.|:|.::|     |:.||:|.
Mouse   287 LGTARPTRSLSTAQLGQLSGGLQASVISNI--VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIF 349

  Fly   178 PGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEP 242
            .||.|..||||:.||.||::...::..:..:......:|:                       :.
Mouse   350 AGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA-----------------------KK 391

  Fly   243 G--TAVVPTRVLVDPA-------ELERYLIST------GYPEIFGESSTASTPQTTTEDDRFVYR 292
            |  |..|.||:...|:       .|.|.|.|:      ..|  |...|.|| |.:|.:
Mouse   392 GLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSP--FSLESPAS-PASTAK------- 446

  Fly   293 GETSMLIDPNIDLEELLALPETEKLQVELKKDAN-GLGI---TIAGYVCEKEELSGIFVKSVSPG 353
                    ||..:          .::|.|||:|. ||||   :|..:.|    :|||||.::|||
Mouse   447 --------PNYRI----------MVEVSLKKEAGVGLGIGLCSIPYFQC----ISGIFVHTLSPG 489

  Fly   354 SAADLSGRIRVNDRIIEVDGQSL------QGY---------------SNH--------------- 382
            |.|.|.||:|..|.|:|::...:      :.|               |.|
Mouse   490 SVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVA 554

  Fly   383 QAVELLK--KSGQVVNL----RLERYLRG-------------PKFEQLQQAIAANDKLPSSAPGT 428
            ||||.:|  |.....:|    |||....|             |...:.|:.:..:....|...|:
Mouse   555 QAVEGVKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGS 619

  Fly   429 PSRAPM-----PTPVATTSSATTTPSRSITRELE----------EEALPAPEAF--MTTPPSVTT 476
            |..:|.     |.| :....:|.:||.|...|.|          :|:.|.||:.  .:.||
Mouse   620 PGGSPCSAGAEPQP-SEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPP---- 679

  Fly   477 MTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPE----LSD 537
              .....||.     :.||.......|..|.:..    |.:::....:...:..|||.    .:.
Mouse   680 --LRLKKSFE-----ILVRKPTSSKPKPPPRKYF----KNDSEPQKKLEEKEKVTDPSGHTLPTC 733

  Fly   538 DAETEIIRKWQKIVGSDVEVIVAQIKKFAVG----------GLGISLEGTVDVEGGREVRPHHYI 592
            ..||.             |::...:::...|          |...|.:.:...||  |.|
Mouse   734 SQETR-------------ELLPLLLQEDTAGRAPCTAACCPGPAASTQTSSSTEG--ESR----- 778

  Fly   593 RSILPDGPV--GVNGVLRSG---DELLEVNGE---------------RLLGMNHLEVVAILKELP 637
            ||..|:.|.  |.:.:|:..   |...::..|               .::..||       ...|
Mouse   779 RSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENH-------SHTP 836

  Fly   638 LDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAA 702
            |......|....:...|  :..|.|:  :..|..|   |:.|: :|||     :|..|..||...
Mouse   837 LQPNTSLGEEDGTQGCP--EGGLSKM--DAANGAP---RVYKS-ADGS-----TVKKGPPVAPKP 888

  Fly   703 ASFSK----LKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPL--DPNDTLIVIRSL 761
            |.|.:    |::|:.:|       ...|::...::            ..|:  ||
Mouse   889 AWFRQSLKGLRNRAPDP-------RRPPEVASAIQ------------PTPVSRDP---------- 924

  Fly   762 VPGGVAQLDGRLIPGDRLLFVNSINLENASL-DQAVQALK-----------------GASKGVVR 808
             ||...|....:    |....:..|..::.| |:.||.|.                 |...|::.
Mouse   925 -PGPQPQASSSI----RQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPGKQDGGRFSGLLG 984

  Fly   809 IGVAKPLPMTDNSLKACSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMGAEPD 864
            .|...........:::.|.....|.|..|     |.||...||...|| :....||
Mouse   985 QGATVTAKHRQTEVESMSTTFPNSSEVRD-----PGLPESPPPGQRPS-TKALSPD 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	9/57 (16%)
		PDZ_signaling	154..226	CDD:238492	23/76 (30%)
		PDZ_signaling	318..400	CDD:238492	39/127 (31%)
		PDZ_signaling	557..643	CDD:238492	19/115 (17%)
		PDZ_signaling	726..807	CDD:238492	16/100 (16%)
Il16	NP_001347016.1	PDZ_signaling	316..391	CDD:238492	24/99 (24%)
		PDZ_signaling	454..536	CDD:238492	29/85 (34%)
		Atrophin-1	<620..931	CDD:331285	74/396 (19%)
		PDZ_signaling	1206..1283	CDD:238492
		PDZ_signaling	1328..1409	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900