DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and Patj

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	960	Identity:	295/960 - (30%)
Similarity:	421/960 - (43%)	Gaps:	290/960 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQ 68
            :|:....||.::.::..:.|..|....    |.||.....|:.|:|..|:.:|.|:.:|..||:.
Mouse     6 AAEKMQVLQVLDRLRGKLQEKGDTTQN----EKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSH 66

  Fly    69 HPSMLPNDFDIDVAGNLVL---SLNGGEVM--------------------YDF------------ 98
            .||....:||....|.||.   |:..|...                    .||
Mouse    67 IPSDCSANFDFSRKGLLVFTDGSITNGNAQRPCSNVTASELLPWTQKSASEDFNSVIQQMAQGRH 131

  Fly    99 ----DEQRSSS----------HSHSA-----------PGS----------PDKSGGVGEEPRPQS 128
                |.:|.|:          .|.|.           |||          .|:...:.:.|..|:
Mouse   132 VEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGSVADRDHRLKENDQILAINDTPLDQN 196

  Fly   129 ----------QNSKGA-------------GVADLYATD--------YAQIQAIELVNDGTGLGFG 162
                      |.:.|:             |.|...:.|        :...:.:||:|||:|||||
Mouse   197 ISHQQAIALLQQATGSLRLVVAREVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGFG 261

  Fly   163 IIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVAR 227
            |:|.::|||:|:||:|||:||:||||::|||||:||..|:..|.|||||.|||..|..||::|||
Mouse   262 IVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326

  Fly   228 PVEQSVPTPQYALEPGTAV-VPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVY 291
            .     |..:.|:.|.|.| :|..:   ||...|                      |.:.||..:
Mouse   327 D-----PVGEIAVTPPTPVSLPVAL---PAVATR----------------------TLDSDRSPF 361

  Fly   292 RGETSMLIDPNIDLEELLALPETEKLQVEL-KKDANGLGITIAGYV--CEKEELSGIFVKSVSPG 353
                                   |...||| |||...|||.|.|||  ....|.|||:|||:.||
Mouse   362 -----------------------ETYSVELVKKDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPG 403

  Fly   354 SAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLER---YLRGPKFEQLQQAI 415
            |||..:|:|:|||:|:.|||.::||::|...||:|:.:||||:|.|.|   .|....||.
Mouse   404 SAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEH----- 463

  Fly   416 AANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTT 480
            :::.:..:..|..|.||..|.|.|           :::.|.||
Mouse   464 SSSRETVAEPPKVPERAGSPKPEA-----------NLSVEAEE---------------------- 495

  Fly   481 TLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPE-LSDDAETEII 544
                  .|::|    |:|                    ||:.|....|....|| :....|.|:.
Mouse   496 ------IGERL----DNL--------------------KNNTVQALEKPDVYPEKVPGSPENELK 530

  Fly   545 RKWQKIVGSDVEVIVA----------QIKKFA----VGGLGISLEGTVDVEGGREVRPHHYIRSI 595
            .:|:.::|.|.||:||          :::|::    :..|.:.:|  ||...|     ||||.|:
Mouse   531 SRWENLLGPDYEVMVATLDAQIADDEELQKYSKLLPIHTLRLGME--VDSFDG-----HHYISSV 588

  Fly   596 LPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTL 660
            .|.|||....:|:..||||||||.:|.|.:..|.|:.|||:|....:||.|..      |.|:..
Mouse   589 APGGPVDTLNLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL------FDDEAS 647

  Fly   661 KKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLTGLAMWSSQ 725
            .......|   ||   |::|:.|.|:..  ::.|.|.                   ..||:||.:
Mouse   648 VDEPRTME---PA---LLEAEVDHSVDV--NIEDDDD-------------------GELALWSPE 685

  Fly   726 PQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENA 790
            .:.:||||..:|||||||||||||||..::|||||||..|||:..|.|:|||||:.||..:|:||
Mouse   686 VKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNA 750

  Fly   791 SLDQAVQALKGASKGVVRIGVAKPL--PMTDNSLKACSNASTTSEETLDA 838
            :|.:||:.||....|||.:|:.|||  ...:......||.:..|.|..||
Mouse   751 TLAEAVEVLKAVPPGVVHLGICKPLVEDEKEERFSLHSNNNGDSSEPADA 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	15/57 (26%)
		PDZ_signaling	154..226	CDD:238492	45/71 (63%)
		PDZ_signaling	318..400	CDD:238492	45/84 (54%)
		PDZ_signaling	557..643	CDD:238492	35/99 (35%)
		PDZ_signaling	726..807	CDD:238492	47/80 (59%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549	13/56 (23%)
		PDZ_signaling	135..218	CDD:238492	47/103 (46%)
		PDZ_signaling	248..325	CDD:238492	12/78 (15%)
		PDZ_signaling	363..450	CDD:238492	31/89 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		3/31 (10%)
		PDZ_signaling	572..636	CDD:238492	27/63 (43%)
		PDZ	685..774	CDD:214570	37/88 (42%)
		PDZ_signaling	1072..1163	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219
		PDZ	1242..1327	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7175
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm42890
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4712
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800