DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and PARD3B

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	1079	Identity:	215/1079 - (19%)
Similarity:	342/1079 - (31%)	Gaps:	401/1079 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KGIDESDDPKLQ--MQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSMLPNDFDIDV 81
            :||:::...|.:  ....|.:..|..:  |.|.:|....||    :..|..:.||:|
Human   242 RGIEDNSRSKREGLFHENECIVKINNV--DLVDKTFAQAQD----VFRQAMKSPSVL-------- 292

  Fly    82 AGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGS----PDKSGGVGEEPRPQSQNSKGAGVADLYAT 142
                         ::....|....:..|..||    .:..|.:..:..|......|...|:|..|
Human   293 -------------LHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGT 344

  Fly   143 DYAQIQA----------------------------------------IELVNDGTGLGFGIIGAR 167
            |..:..|                                        |:|.....||||.:: .|
Human   345 DSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV-TR 408

  Fly   168 NSG------VIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLR--QSGTHVRLV 224
            :|.      :.||.|||.|.|.|||||:|||.||::...::.....|::.|:||  :.|....||
Human   409 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 473

  Fly   225 VARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRF 289
            :||.....:|.                                 |:.||....:
Human   474 IARQEGHFLPR---------------------------------ELKGEPDCCA----------- 494

  Fly   290 VYRGETSMLIDPNIDLEELLALPETEKLQVEL---KKDANGLGITIAGYVCEKEELS-GIFVKSV 350
                               |:|..:|:|..|:   ...:.|||:::.|....:.... |||:||:
Human   495 -------------------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSI 540

  Fly   351 SPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRG---------- 405
            ..|.||...||:|:||::|.|:|:||.|.|||:|:|.|::|     :.:|..:||
Human   541 IHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS-----MSMEGNIRGMIQLVILRRP 600

  Fly   406 ---------------PKFEQLQQAIAAN-----------------DK-----LPSSAPGTPSRAP 433
                           |.||..|.|:..:                 ||     ||:.........|
Human   601 ERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPP 665

  Fly   434 MPTPVAT-------------TSSATTTPS-----RSIT--RELEEEALPAPEAFMTTP------- 471
            .|||.:.             ..||...|.     ||:|  |:.|...|.|.::....|
Human   666 SPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHS 730

  Fly   472 --------------PSVTTMTTTTLSSF-------------------------GAGKQL-VAVRD 496
                          |::....:::|.|.                         |..:.. .|:..
Human   731 LAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDK 795

  Fly   497 SLDGSTKIIPTEVVPLADKTEAKNSGVI------------------------TRHKYYTDPELSD 537
            |.||..:|   |...|:||:.....|.:                        |:.|    .:..:
Human   796 SYDGPEEI---EADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK----EKKKE 853

  Fly   538 DAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVG 602
            ..:.::..|.:|....|.|   .:|||...|.: :......:.:||:..:
Human   854 KGKLKVKEKKRKEENEDPE---RKIKKKGFGAM-LRFGKKKEDKGGKAEQ--------------- 899

  Fly   603 VNGVLRSG----DELLEVNGER-LLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLK- 661
             .|.|:.|    :||.::..|| .:|..|.|    |:|......:........|:....||.:.
Human   900 -KGTLKHGGLREEELEKMKEERERIGAKHQE----LREKQARGLLDYATGAIGSVYDMDDDEMDP 959

  Fly   662 --KLSNNFENLLPATD-RLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPL------- 716
              ...|:|..  |.|. .:.::.|.......|...||..::........|.::..:|.
Human   960 NYARVNHFRE--PCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPAD 1022

  Fly   717 TGLAMWSSQPQIIELVK---GDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGD- 777
            :|.....|..:|.:|.|   ..|..||.:  |:|.                     :||..|.:
Human  1023 SGRPTGGSTDRIQKLRKEYYQARREGFPL--YEDD---------------------EGRARPSEY 1064

  Fly   778 RLLFV-------NSINLENASLDQAVQALKGASKGVVRIGVAKP---LPMTDNSLKACSNASTTS 832
            .||:|       |:.||....:::...:|.       |.|.|.|   ||.....|        ..
Human  1065 DLLWVPGRGPDGNAHNLRFEGMERQYASLP-------RGGPADPVDYLPAAPRGL--------YK 1114

  Fly   833 EETLDAQPSPPALPTVAPPAMPPSASMGAEPDL-IPDWR 870
            |..|...|.       |.|..||..|.....:| :.|.|
Human  1115 ERELPYYPG-------AHPMHPPKGSYPRPTELRVADLR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	11/52 (21%)
		PDZ_signaling	154..226	CDD:238492	30/79 (38%)
		PDZ_signaling	318..400	CDD:238492	31/85 (36%)
		PDZ_signaling	557..643	CDD:238492	18/90 (20%)
		PDZ_signaling	726..807	CDD:238492	18/91 (20%)
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492	14/80 (18%)
		PDZ_signaling	395..475	CDD:238492	30/80 (38%)
		PDZ_signaling	509..597	CDD:238492	33/92 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810