DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and PATJ

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	962	Identity:	288/962 - (29%)
Similarity:	407/962 - (42%)	Gaps:	307/962 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQ 68
            :.|....||.::.:|..:.|..|....    |.||.....|:.|:|..|:.:|.|:.:|..||..
Human     6 ATDKLQVLQVLDRLKMKLQEKGDTSQN----EKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNH 66

  Fly    69 HPSMLPNDFDIDVAGNLVL---SLNGGEVMYDFDEQRSSSHSHSA---PGSP------------- 114
            .||....:||....|.||.   |:..|.|      .|.|::|..:   |.:|
Human    67 IPSDCSANFDFSRKGLLVFTDGSITNGNV------HRPSNNSTVSGLFPWTPKLGNEDFNSVIQQ 125

  Fly   115 --------------DKSGGVG-EEPRPQSQNSKGAGVADLYATD--------------------- 143
                          ..:||:| .....:|||   .|..|::..|
Human   126 MAQGRQIEYIDIERPSTGGLGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILA 187

  Fly   144 -------------------------------------------------------YAQIQAIELV 153
                                                                   :..::.:||:
Human   188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELI 252

  Fly   154 NDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSG 218
            |||:||||||:|.:.|||:|:||:|||:||:||||::|||||:||..|:..|.|||||.|||..|
Human   253 NDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG 317

  Fly   219 THVRLVVAR-PVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQT 282
            ..||::||| |......||     |..|.:|..:   |....:           |..|.:|..:|
Human   318 NSVRMLVARDPAGDISVTP-----PAPAALPVAL---PTVASK-----------GPGSDSSLFET 363

  Fly   283 TTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYV--CEKEELSGI 345
            .                  |::|               ::||...|||.|.|||  ....|.|||
Human   364 Y------------------NVEL---------------VRKDGQSLGIRIVGYVGTSHTGEASGI 395

  Fly   346 FVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQ 410
            :|||:.|||||..:|.|:|||:|:.|||.::||::||..||:|:.:||||:|.|.|
Human   396 YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR--------- 451

  Fly   411 LQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVT 475
                                        ..|||:|:.......|....|.|..|..|:|
Human   452 ----------------------------RKTSSSTSPLEPPSDRGTVVEPLKPPALFLT------ 482

  Fly   476 TMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAE 540
                      ||    |....::||..:.|...:..|      ||..:....|....|   |..|
Human   483 ----------GA----VETETNVDGEDEEIKERIDTL------KNDNIQALEKLEKVP---DSPE 524

  Fly   541 TEIIRKWQKIVGSDVEVIV----------AQIKKFA----VGGLGISLEGTVDVEGGREVRPHHY 591
            .|:..:|:.::|.|.||:|          |:::|::    :..|.:.:|  ||...|     |||
Human   525 NELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVE--VDSFDG-----HHY 582

  Fly   592 IRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFS 656
            |.||:..|||...|:|:..||||||||.:|.|.:..|.|:.|||:|....:||.|..      |.
Human   583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL------FD 641

  Fly   657 DDTLKKLSNNFENLLPATD----RLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLT 717
            |:.........|..||.|:    ..|..:.|.         ||:
Human   642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDD---------DGE--------------------- 676

  Fly   718 GLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFV 782
             ||:||.:.:|:||||..:|||||||||||||||..::|||||||..|||:..|.|:|||||:.|
Human   677 -LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSV 740

  Fly   783 NSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEE 834
            |...|:|.||.:||:.||....|:|.:|:.||| :.||..::|....::|.|
Human   741 NEYCLDNTSLAEAVEILKAVPPGLVHLGICKPL-VEDNEEESCYILHSSSNE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	16/57 (28%)
		PDZ_signaling	154..226	CDD:238492	45/71 (63%)
		PDZ_signaling	318..400	CDD:238492	42/83 (51%)
		PDZ_signaling	557..643	CDD:238492	36/99 (36%)
		PDZ_signaling	726..807	CDD:238492	48/80 (60%)
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611	17/60 (28%)
		PDZ_signaling	135..218	CDD:238492	9/85 (11%)
		PDZ_signaling	246..325	CDD:238492	47/78 (60%)
		PDZ_signaling	366..450	CDD:238492	43/98 (44%)
		PDZ_signaling	570..634	CDD:238492	31/70 (44%)
		PDZ	683..772	CDD:214570	50/88 (57%)
		PDZ_signaling	1066..1157	CDD:238492
		PDZ	1236..1321	CDD:214570
		PDZ	1459..1574	CDD:214570
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7199
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm40813
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4712
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800