DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and whrn

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_012824768.2	Gene:	whrn / 100486736	XenbaseID:	XB-GENE-989669	Length:	996	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	153/790 - (19%)
Similarity:	257/790 - (32%)	Gaps:	292/790 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 HSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGA--RN 168
            |....||:|.   |....| |::.           .|:..|: .::...:..||||.|.|.  ..
Frog   208 HRPPYPGAPP---GFSNSP-PRAN-----------PTEVRQV-TLKRNRNQEGLGFSIRGGVEHG 256

  Fly   169 SGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQS--------------GT 219
            :|:.|..:.||.:|:::| ||.||.||:.....|..:...:....||.|              |.
Frog   257 TGIYVSLVEPGSLAEQEG-LRVGDQILKANGRPLDRVTHAEAVKALRGSQKLVLSVLSSGRIPGG 320

  Fly   220 HVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTT 284
            |:...:...|:..          |.:|.|.|   .|..|:..|::                  .|
Frog   321 HISSHIYTWVDAH----------GRSVSPPR---GPPHLQSPLLA------------------GT 354

  Fly   285 EDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVEL-KKDANGLGITIAGYVCEKEELSGIFVK 348
            |.::                ...|..|.|.::.:|.| ..:.:.||:.|.|   ..|...||::.
Frog   355 EQEK----------------RSHLQLLQEGDEKKVNLVLGEGSSLGLLIRG---GAEYSLGIYIT 400

  Fly   349 SVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQ 413
            .|..||.|:.:| ::|.|:|::::|.|.....:.:||.:|..|                 ..|..
Frog   401 GVDKGSEAESAG-LKVGDQILDINGSSFLSIPHDEAVRILGSS-----------------RHLMM 447

  Fly   414 AIAANDKLPSSAPGTPSRAPMPTPVATTSSAT----TTPSRSITRELEEEALPAPEAFMTTPPSV 474
            .:....::|.      :|..:......|||.|    ..||.....:...::|..| .|...|
Frog   448 TVRDVGRIPH------ARTIVDETQWLTSSYTGNGEPQPSLGTLSDTSSDSLVKP-VFCRGP--- 502

  Fly   475 TTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDA 539
             |.:..||||.|             ..|.::..|...|. .||.:.|.:....:.|.|..:|
Frog   503 -TGSQVTLSSLG-------------NQTLVLLEEKARLL-LTEPERSTMSYYLQQYKDHHIS--- 549

  Fly   540 ETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVN 604
                   .|.::.:..|::..|.|..|...|...|..                 .|||
Frog   550 -------VQALIMAMFELLNTQAKVTATFSLLSELRS-----------------QILP------- 583

  Fly   605 GVLRSGDELLEVNGERLLGMNHLEVVAILKELPL--DVRMVCGRNRNSSLLPFSDDTLKKLSNNF 667
                                   :.:|:...|.|  ::..:..|.|       |.||:..||.
Frog   584 -----------------------QDLAVFDNLVLKREIESMKSRQR-------SGDTVSVLSQ-- 616

  Fly   668 ENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELV 732
                             :|:|:.|.:. .:|:.|:.:..:|            :|     :::::
Frog   617 -----------------TLSTSSSESH-QTVSTASTARERL------------LW-----LLDVM 646

  Fly   733 KGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSI-----NLENASL 792
            :..          .||...:|:..:.::.:|.  ..||.          |||:     |.:.|..
Frog   647 ENG----------TDPEGSSDSRSLTQTTLPD--ISLDD----------VNSLLEEPPNFQPAPP 689

  Fly   793 DQAVQ-----------ALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLDAQPSPPALP 846
            ..|||           ..:..|.|..:.|:...:|.|:                    ||||..|
Frog   690 QSAVQNAPQLRRQGRERAQRPSSGSSQSGLFFTVPSTN--------------------PSPPLPP 734

  Fly   847 TVAPPAMPPS 856
            ..:|||.|.|
Frog   735 LTSPPASPSS 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	24/87 (28%)
		PDZ_signaling	318..400	CDD:238492	23/82 (28%)
		PDZ_signaling	557..643	CDD:238492	11/87 (13%)
		PDZ_signaling	726..807	CDD:238492	16/96 (17%)
whrn	XP_012824768.2	harmonin_N_like	40..117	CDD:416392
		PLN02983	<144..>217	CDD:215533	3/8 (38%)
		PDZ_signaling	231..312	CDD:238492	23/82 (28%)
		PDZ_signaling	370..450	CDD:238492	24/100 (24%)
		HN_L-whirlin_R2_like	513..597	CDD:259823	23/154 (15%)
		PDZ_signaling	905..976	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910