DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Patj and patj

DIOPT Version :9

Sequence 1:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_002931635.3	Gene:	patj / 100036704	XenbaseID:	XB-GENE-998168	Length:	1829	Species:	Xenopus tropicalis

Alignment Length:	947	Identity:	283/947 - (29%)
Similarity:	412/947 - (43%)	Gaps:	268/947 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLA 67
            ::.|.:..|...|.::|.:.:..|    :...|.:..:...|:.|:|..|:.||.|:.:|..||.
Frog    10 VTVDKAQVLLIAERLQKKLKDKGD----LSHHEKMCILRDTLKSPLFNQILTVQQSIKQLKEQLN 70

  Fly    68 QHPSMLPNDFDIDVAGNLVLSLNGG------EVMYDFDEQRSSSHSHSAPGSPDK---------- 116
            :.|:....:||....|.||...:..      .....||...||.....:|.|.|:
Frog    71 RMPADRSAEFDFTKKGLLVFEADSSAHFGNKNNSLSFDNFVSSQLPLVSPYSEDEFNRKLQQMAE 135

  Fly   117 -------------SGGVG------------------EEPRPQS---------------------- 128
                         .||:|                  .|.:|.|
Frog   136 GRQIEYIDIEKPSVGGLGFSVVALKNPTVGEAGVFIREVQPGSIADKDGRLKENDQILAINYIPL 200

  Fly   129 -------------QNSKG--------AGVADLYAT---------DYAQIQAIELVNDGTGLGFGI 163
                         |.|.|        |.|.:.:..         .:..::.|||:|||:||||||
Frog   201 DMSVSHQESIAMLQQSSGSIRLVVAKAPVLNNFQALSNNLDNQIQWGHVEDIELINDGSGLGFGI 265

  Fly   164 IGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVAR- 227
            :|.:.|||||:||:.||:||:||||::|||||||||.|:..|.|:|||.|||..|..|::||||
Frog   266 VGGKASGVIVRTIVSGGLADRDGRLKTGDHILQIGDTNVQGMASDQVAQVLRNCGNSVKMVVARD 330

  Fly   228 PVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYR 292
            |:|:....|..|..|..|:.|..|..|                             .|:...||
Frog   331 PIERPSKPPAPATLPVGALPPKDVKGD-----------------------------NENTDNVY- 365

  Fly   293 GETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYV-CEKEELSGIFVKSVSPGSAA 356
                     :|.|               .||:...||||:.||. ......|||:|||:.|||||
Frog   366 ---------DIKL---------------TKKEGQSLGITVVGYTGAFNGGSSGIYVKSIIPGSAA 406

  Fly   357 DLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKL 421
            |.||.|:|.||||.|||.::|.|||...|..|:.:||.|:|.|.|      .::|.:.:|....|
Frog   407 DQSGCIQVQDRIIAVDGVNIQDYSNQDVVAALRNTGQTVHLTLSR------SKELLELVATERSL 465

  Fly   422 PSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFG 486
            ..:.||.||..|:|           ..::|...|..:|.:...:..|.| .|::..|:...|.:
Frog   466 VRAVPGLPSDPPVP-----------EINKSSANEENQEQVDNYKNEMIT-GSLSPQTSILKSKW- 517

  Fly   487 AGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIV 551
                          ..::.|..:|.:.:                .||::.||||   ::|:.|::
Frog   518 --------------EQRLGPDYLVMVVN----------------LDPKIDDDAE---LQKYSKLL 549

  Fly   552 GSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEV 616
                        ......||:.|:   ..:|      ||||.||.|:|||...|:.:..||||||
Frog   550 ------------PIHTMRLGVELD---SFDG------HHYISSIAPEGPVAKLGIFQPEDELLEV 593

  Fly   617 NGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFE-----NLLPATDR 676
            ||.:|.|.:..|.|:.|||:|....:||.|.    ::...::|...:.|..:     |.:|.|:.
Frog   594 NGVQLYGKSRREAVSFLKEVPPPFTLVCCRR----MVDDENETFVDVPNTLDTKDNKNEIPVTEE 654

  Fly   677 LVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLT------GLAMWSSQPQIIELVKGD 735
                             :..:|.::..|.|:. ::.||.|.      .||||||:.:::||.|..
Frog   655 -----------------EDQTVQSSERSNSEY-AQPLENLVTEEDDGELAMWSSEVKVVELEKDS 701

  Fly   736 RGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALK 800
            .|||||||||||||||..|::||:|||..|||:..|:::|||||:|||...::||||:.|||.|.
Frog   702 GGLGFSILDYQDPLDPARTVLVIQSLVSNGVAETSGQILPGDRLVFVNDNYMDNASLEDAVQILT 766

  Fly   801 GASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLD 837
            ....|..|:|:.|||.   .|:|...:..|..||..|
Frog   767 SVPPGRTRLGICKPLV---GSIKEEKDIYTNLEELED 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Patj	NP_477342.1	L27	12..70	CDD:295425	14/57 (25%)
		PDZ_signaling	154..226	CDD:238492	46/71 (65%)
		PDZ_signaling	318..400	CDD:238492	41/82 (50%)
		PDZ_signaling	557..643	CDD:238492	31/85 (36%)
		PDZ_signaling	726..807	CDD:238492	45/80 (56%)
patj	XP_002931635.3	L27_2	13..70	CDD:312549	15/60 (25%)
		PDZ_signaling	142..225	CDD:238492	9/82 (11%)
		PDZ_signaling	256..328	CDD:238492	46/71 (65%)
		PDZ_signaling	364..449	CDD:238492	45/109 (41%)
		PDZ_signaling	556..620	CDD:238492	31/72 (43%)
		PDZ_signaling	692..770	CDD:238492	44/77 (57%)
		PDZ_signaling	1014..1105	CDD:238492
		PDZ	1186..1271	CDD:214570
		PDZ	1383..1468	CDD:214570
		PDZ_signaling	1480..1560	CDD:238492
		PDZ_signaling	1624..1709	CDD:238492
		PDZ_signaling	1744..1828	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm48009
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000