DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rasp and hhat

DIOPT Version :9

Sequence 1:	NP_523898.1	Gene:	rasp / 44098	FlyBaseID:	FBgn0024194	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001108362.2	Gene:	hhat / 560334	ZFINID:	ZDB-GENE-051118-1	Length:	508	Species:	Danio rerio

Alignment Length:	548	Identity:	140/548 - (25%)
Similarity:	227/548 - (41%)	Gaps:	132/548 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTRCEIFVYFGVYIAYIVVGLYKIYGL-RDHIVK-EAKFQFPEGWSLYPFSQRRRDDSNDELENF 72
            |.|.|:..|:.:..:......|:::.. ::|.|. :.:.|...|:.|:.|   ::|.:
Zfish    10 LPRWEMVAYWILSFSSHFYSFYQLHSFSKEHEVSLDKEVQLERGFLLWGF---KKDPT------- 64

  Fly    73 GDFIVSFW--------------------------PFYLLHV-AVQGFIR--WKRPRLQCLGFIGV 108
             ||..|||                          |.|.|.| |:.|.|.  |      .||..||
Zfish    65 -DFEWSFWNEWAWRSLLWSLIGHAVVSRLAYYYLPQYRLAVFAMYGLISAGW------ILGVRGV 122

  Fly   109 CALALSVNLDWSSMVLLVTLIASYYIVSLLSLKFLVWLLSAGWILCINV-----MQKNVWWTDRV 168
            ..|.|.:::.              .:|:.|....|.|..|...:..:||     :|:. |:|...
Zfish   123 IVLMLHLSIS--------------LVVAQLRSPVLSWFCSLLLLSTLNVSALQDLQRG-WYTSED 172

  Fly   169 GYTEYVLVIVT-------------MSWSVLRG-----CSYSLSKIGAKQEDLTRYSLVQYLGYAM 215
            .|  |:|:..|             |.|..|:.     || ||.....|   ...|..::...:..
Zfish   173 QY--YLLLFSTAVCSLHCISFCLEMCWHPLQAGRPKHCS-SLQNCALK---TLIYQFLKLTAFCF 231

  Fly   216 YFPCLTYGPIISYQRFAARREDEV--QNWLGFVGGVLRSAIWWLVMQCALHYFYIHYMSRDVRMV 278
            |.|....|||::|:.|:.:.|..:  .:.|....|:||..:||.:.:..:|:.|:|.:..:...:
Zfish   232 YHPLFYNGPIMTYKDFSEQIERPLCKVSALHVFSGILRLCVWWCLAEFMIHFMYMHAIQSNETYL 296

  Fly   279 EMMDSVFWQHSAGYFMG-------QFFFLYYVVTYGLGIAFAVQDGIPAPNRPRCIGRIHFYSDM 336
            ||:..  |.      ||       |||::.|:|.:|........||:..|..|||:..::.::.|
Zfish   297 EMLPP--WA------MGGLALALVQFFYVKYLVLFGAVSLLVRLDGLEPPTLPRCVSIMYSFTGM 353

  Fly   337 WKYFDEGLYEFLFQNIYAELCGKRSSAAAKFGATALTFAFVFVWHGCYTYVLIWSILNFLCLAAE 401
            |::||.|||::|.:.||..|.|.|..|..|..:|||.|.||..||||:.|:|.|::||::.:..|
Zfish   354 WRHFDVGLYKWLIRYIYVPLGGSRHGAFRKLLSTALAFGFVCFWHGCHDYLLYWALLNWVGVLVE 418

  Fly   402 KVFKTFTAMPEYQ---------RWTQRHLGAVGAQRLYAMLATQLFIPAAFSNVYFIGGQEIGDF 457
            ..|....:.|..:         |..:|.|..:.|      .:|...|   .||::|:||..:|..
Zfish   419 NAFALLFSSPPLRHAIVYCLTPRMQRRGLALISA------FSTAFLI---LSNLFFLGGTHVGRI 474

  Fly   458 LMRGAYL---SGVGNYVALCFCSYCFFQ 482
            ..:..::   |.|.  |.:....|||.|
Zfish   475 FWKKLFVQDWSSVA--VPMVAFLYCFAQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rasp	NP_523898.1	MBOAT	128..444	CDD:281107	96/356 (27%)
hhat	NP_001108362.2	CBP_BcsG	64..>111	CDD:299837	11/54 (20%)
hhat	NP_001108362.2	MBOAT	<220..432	CDD:294479	68/219 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595442
Domainoid	1	1.000	136	1.000	Domainoid score	I4901
eggNOG	1	0.900	-	-		E1_COG1696
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41232
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4343
OMA	1	1.010	-	-		QHG49284
OrthoDB	1	1.010	-	-		D205353at33208
OrthoFinder	1	1.000	-	-		FOG0002917
OrthoInspector	1	1.000	-	-		otm25345
orthoMCL	1	0.900	-	-		OOG6_102319
Panther	1	1.100	-	-	LDO	PTHR13285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1684
SonicParanoid	1	1.000	-	-		X2607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800