DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rasp and Hhat

DIOPT Version :9

Sequence 1:	NP_523898.1	Gene:	rasp / 44098	FlyBaseID:	FBgn0024194	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_011237236.1	Gene:	Hhat / 226861	MGIID:	2444681	Length:	508	Species:	Mus musculus

Alignment Length:	526	Identity:	136/526 - (25%)
Similarity:	215/526 - (40%)	Gaps:	115/526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPDRSLLTRCEIFVYFGVYIAYIVVGLYKIYGLRDHIVKEAKFQ---FPEGWSLYPFSQRRRDDS 65
            |.||..:..|:. |:...|:               .:::|.:.:   ||.||     .:..:...
Mouse    35 LRDRGRIWPCDC-VFLTCYL---------------RLIREQERELDCFPGGW-----GEESQLTG 78

  Fly    66 NDELENFGD-----FIVSFWPFYLLH----VAVQGFIRWKRPRLQC---LGFIGVCALALSVNLD 118
            ..|::....     .:|:. ||  .|    |.|.|.  |     .|   ||..||.
Mouse    79 KSEVKGCSSPSHTGTVVAL-PF--AHRPWIVMVYGM--W-----ACWCVLGAPGVV--------- 124

  Fly   119 WSSMVLLVTLIASYYIVSLLSLKFLVWLLSAGWILCINVMQ-------KNVWWTDRVGYTEYVLV 176
               ||||.:.||  :.|:......|.||.|   :|.::.::       |..|:...   .||.|:
Mouse   125 ---MVLLHSTIA--FCVAQFRSVLLSWLCS---LLLLSTLRLQSVEEVKRRWYKTE---NEYYLL 178

  Fly   177 IVTMSWSVLRGCSYSL-------------SKIGAKQEDLTRYSLVQYLGYAMYFPCLTYGPIISY 228
            ..|::...|...|:||             |..||.      :|....|.|..|:|....|||:::
Mouse   179 QFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGAS------HSYPWLLTYVFYYPVFHNGPILNF 237

  Fly   229 QRFAARRE----DEVQNWLGFVG-GVLRSAIWWLVMQCALHYFYIH--YMSRDVRMVEMMDSVFW 286
            ..|..:.:    :.:|:.|..|. |:.|...||.:.:..:|..|:|  |.|     ..:::||..
Mouse   238 PEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSS-----APLLESVSC 297

  Fly   287 QHSAGYFMGQ--FFFLYYVVTYGLGIAFAVQDGIPAPNRPRCIGRIHFYSDMWKYFDEGLYEFLF 349
            ....|..:.|  ||::.|:|.:|:.......||:..|..|||:..:..::.||:|||.||:.||.
Mouse   298 WTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLI 362

  Fly   350 QNIYAELCGKRSSAAAKFGATALTFAFVFVWHGCYTYVLIWSILNFLCLAAEKVFKTFTAMPEYQ 414
            :.:|..|.|.:........:||.|||||..|||.|..:..|:.||:|.:..|...:.....|..:
Mouse   363 RYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVR 427

  Fly   415 RWTQRHLGAVGAQRLYAMLA---TQLFIPAAFSNVYFIGGQEIGDFLMRGAYLSGVGNYVALCFC 476
            ....|||......||:|:||   |.:.|   ..|:.|:||.::|.......:|.| ..:|.|...
Mouse   428 ETLARHLSPQAHHRLHALLAACSTSMLI---LFNLVFLGGIQVGKTYWNRIFLQG-WPWVTLSVL 488

  Fly   477 S--YCF 480
            .  ||:
Mouse   489 GFLYCY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rasp	NP_523898.1	MBOAT	128..444	CDD:281107	96/347 (28%)
Hhat	XP_011237236.1	MBOAT	161..457	CDD:281107	88/312 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849676
Domainoid	1	1.000	123	1.000	Domainoid score	I5613
eggNOG	1	0.900	-	-		E1_COG1696
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41232
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4527
Isobase	1	0.950	-	0	Normalized mean entropy	S4797
OMA	1	1.010	-	-		QHG49284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002917
OrthoInspector	1	1.000	-	-		otm43020
orthoMCL	1	0.900	-	-		OOG6_102319
Panther	1	1.100	-	-	LDO	PTHR13285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1684
SonicParanoid	1	1.000	-	-		X2607
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740