DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and CD22

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	793	Identity:	186/793 - (23%)
Similarity:	301/793 - (37%)	Gaps:	169/793 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PHDLQVLEGAEAMMRCEVANVAGAV------------------------QWTKDGFALGFSAVIP 118
            |..|...|||...:.|....:.|.:                        :.||||       .:|
Human    29 PETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDG-------KVP 86

  Fly   119 G-FPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAI-----RANAKLTVISPPASI 177
            . ..|...|||:.:.. .|.|....:||..    |:| .|:.|..     |.:..::....|..|
Human    87 SEQKRVQFLGDKNKNC-TLSIHPVHLNDSG----QLG-LRMESKTEKWMERIHLNVSERPFPPHI 145

  Fly   178 EIKGYSHNSKVEVRENQDLQLKCIV---ANAKPAAQIVWYRGNVEYKPEKREDTVEES-TAKRFT 238
            ::       ..|::|:|::.|.|::   ....| .|:.|.   :|..|.::......| |.|...
Human   146 QL-------PPEIQESQEVTLTCLLNFSCYGYP-IQLQWL---LEGVPMRQAAVTSTSLTIKSVF 199

  Fly   239 TTSSLKLKPGPDDDYTEYTCQ---ARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRG 300
            |.|.||..|.........|||   |..|.||.|     ||||:|.:.| ...|:...:...:|.|
Human   200 TRSELKFSPQWSHHGKIVTCQLQDADGKFLSND-----TVQLNVKHTP-KLEIKVTPSDAIVREG 258

  Fly   301 QTVELMCRSRGGNPPAQLI-WYKNGSQIRMAYRTSGRLSENIYTFTAE--AGDNKARFRCEASNV 362
            .:|.:.|.....||....: |.|:|:.::         .:|.:|....  ..|...::.|:.||.
Human   259 DSVTMTCEVSSSNPEYTTVSWLKDGTSLK---------KQNTFTLNLREVTKDQSGKYCCQVSND 314

  Fly   363 MSQNPLKAEVELSVLFAPTHVTVM---GPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNA 424
            :... ...||.|.|.:||...||.   .|  |..|..|...|.:..:..|....|...|::::..
Human   315 VGPG-RSEEVFLQVQYAPEPSTVQILHSP--AVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGR 376

  Fly   425 TSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICH-GLNMQLTENVVST------HTINVLYPP-- 480
            |.:.:..|:                    ::..| |....:.||::.|      ..::|.|||
Human   377 TEEKVHIPK--------------------ILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK 421

  Fly   481 APPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANV 545
            ...:|...|.   |..|....|.|..:..||..|...:|.        ..|.:..|..:..:.||
Human   422 VTTVIQNPMP---IREGDTVTLSCNYNSSNPSVTRYEWKP--------HGAWEEPSLGVLKIQNV 475

  Fly   546 SDNQAQYRCEASNS----ATEIPLFQSTTLSVHFAPETVKIR-IEP-EELRPGMEATIICDSSSS 604
            ..:.....|.|.||    |:.:      .|:|.:||..|::| |:| .|:..|...::.||.|||
Human   476 GWDNTTIACAACNSWCSWASPV------ALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSS 534

  Fly   605 NPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEA 669
            :|.....:|:            |.|...|..|.|.|. :::.|..|. |:|. .|.::.::|.:|
Human   535 HPKEVQFFWE------------KNGRLLGKESQLNFD-SISPEDAGS-YSCW-VNNSIGQTASKA 584

  Fly   670 VSLDVLYRPKFVPPPSSTAVGV-EGESLQVSLQTRANPTPVTYKWTK-DGTTIPQDGDHRIFADG 732
            .:|:|||.|:.:....|....| ||:|..::.::.|||....|.|.. :..::|....
Human   585 WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQ------- 642

  Fly   733 GSLNFTRLHRDDAGIYSCSASNSQG-GATLNITVVVEYGTTIKSVSENIVVNPGED-AMLSCTVE 795
             .|....:....:|.|.|..:||.| |.:...|:.|.|..  :::...:.|..|.. |:|...:.
Human   643 -KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP--ETIGRRVAVGLGSCLAILILAIC 704

  Fly   796 GKPLTEEHVKWER 808
            |..|..   :|:|
Human   705 GLKLQR---RWKR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	25/121 (21%)
		Ig	76..155	CDD:299845	21/101 (21%)
		IG_like	186..279	CDD:214653	30/99 (30%)
		Ig	197..279	CDD:299845	27/88 (31%)
		IG_like	296..376	CDD:214653	18/82 (22%)
		Ig	300..361	CDD:299845	12/63 (19%)
		Ig	380..454	CDD:299845	13/76 (17%)
		IG_like	490..573	CDD:214653	18/86 (21%)
		Ig	501..560	CDD:299845	14/62 (23%)
		Ig	584..666	CDD:299845	22/82 (27%)
		IG_like	585..666	CDD:214653	21/81 (26%)
		I-set	678..767	CDD:254352	21/91 (23%)
		IGc2	692..757	CDD:197706	15/65 (23%)
		Ig	788..849	CDD:143165	6/21 (29%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
CD22	NP_001762.2	Ig	24..122	CDD:299845	23/105 (22%)
		C2-set_2	143..228	CDD:285423	23/95 (24%)
		I-set	242..327	CDD:254352	20/95 (21%)
		IGc2	257..316	CDD:197706	14/67 (21%)
		Ig_3	335..400	CDD:290638	14/86 (16%)
		IG_like	343..415	CDD:214653	14/91 (15%)
		IG_like	433..501	CDD:214653	17/81 (21%)
		I-set	510..589	CDD:254352	26/93 (28%)
		IGc2	521..578	CDD:197706	19/71 (27%)
		IG_like	606..677	CDD:214653	19/78 (24%)
		IGc2	608..666	CDD:197706	15/65 (23%)
		ITIM motif 1	760..765
		ITIM motif 2	794..799
		ITIM motif 3	820..825
		ITIM motif 4	840..845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910