Protein Alignment sns and IL1RL2

DIOPT Version :9

• Sequence 1: NP_001036532.1
• Gene: sns / 44097
• FlyBaseID: FBgn0024189
• Length: 1542
• Species: Drosophila melanogaster
• Sequence 2: XP_011510393.1
• Gene: IL1RL2 / 8808
• HGNCID: 5999
• Length: 622
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 104/512 - (20%)
• Similarity: 170/512 - (33%)
• Gaps: 166/512 - (32%)

  Fly   683 PPSSTAVG-----VEGESLQVSLQTRANPT--PVT-----YKWTKDGTTIPQDG--DHRIFADGG 733
            |.|.||.|     ::.|.|..|.....|.|  |:|     ..|.|:.:.||...  ..||..|..
Human    42 PLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDET 106

  Fly   734 SLNFTRLHRDDAGIYSC--SASNSQGGATLNITVVVEY--GTTI---KSVSENI--VVNPGEDAM 789
            .:.|..:...|:|:|.|  ...:|.....:|:||..::  .|:|   .::|:..  :::.|:|..
Human   107 WILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDS 171

  Fly   790 LSCTVE-GKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPT 853
            |:|.:. .|......:||.:   |........|....:.|.:.:...||.||:.|.|
Human   172 LTCHLHFPKSCVLGPIKWYK---DCNEIKGERFTVLETRLLVSNVSAEDRGNYACQA-------- 225

  Fly   854 NRDILLIVKFAPEIAK--TPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYE 916
               ||.......|:..  |.::.||..|            || .|:.|:       |.|.:.:.:
Human   226 ---ILTHSGKQYEVLNGITVSIKRAGYG------------GS-VPKIIY-------PKNHSIEVQ 267

  Fly   917 VEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHD 981
            :          .:|||||           |                           |:.:...:
Human   268 L----------GTTLIVD-----------C---------------------------NVTDTKDN 284

  Fly   982 TVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIG-----GLRMNTLYLFSVMSW 1041
            |....|            ||...:.|    .|.|   .|.::..|     ..|.:.||..:: ::
Human   285 TNLRCW------------RVNNTLVD----DYYD---ESKRIREGVETHVSFREHNLYTVNI-TF 329

  Fly  1042 NELGQSSY-LPDLARAETKEA------PPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGI- 1098
            .|:....| ||.:..|....|      |.|...|..:||                |:..|...:
Human   330 LEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGG----------------LIALVAVAVS 378

  Fly  1099 VVVLLNVFVIGCCLHKRN---------EKRLKRGLELMPAELTEDSSNTPNLVIIGI 1146
            ||.:.|:|.|...|..|:         :.:|.....|.|....|...:..:.:::.|
Human   379 VVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNI 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	28/99 (28%)
		IGc2	692..757	CDD:197706	20/75 (27%)
		Ig	788..849	CDD:143165	14/61 (23%)
		Ig	885..960	CDD:143165	12/74 (16%)
		FN3	967..1051	CDD:238020	15/89 (17%)
IL1RL2	XP_011510393.1	Ig	54..140	CDD:299845	21/85 (25%)
		Ig2_IL1R_like	158..245	CDD:143234	20/100 (20%)
		IG_like	171..229	CDD:214653	16/71 (23%)
		TIR	413..563	CDD:279864	4/23 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910