DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Robo2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_038944599.1	Gene:	Robo2 / 84409	RGDID:	620167	Length:	1625	Species:	Rattus norvegicus

Alignment Length:	1240	Identity:	269/1240 - (21%)
Similarity:	419/1240 - (33%)	Gaps:	341/1240 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 PPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKS---------VSA 537
            ||.|..:....|:..|....|.| .:.|.|..|:.|||:.:|:.:     ||.         .|.
  Rat    53 PPRIVEHPSDVIVSKGEPTTLNC-KAEGRPTPTIEWYKDGERVET-----DKDDPRSHRMLLPSG 111

  Fly   538 EITILANV-----SDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE--LRPGMEA 595
            .:..|..|     ..::..|.|.|.|...|.   .|...|:..|......|..|.:  :..|..|
  Rat   112 SLFFLRIVHGRRSKPDEGTYVCVARNYLGEA---VSRNASLEVALLRDDFRQNPTDVVVAAGEPA 173

  Fly   596 TIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANE 660
            .:.|.....:|...:.|.||.:.|:  ....:..:.||     :..::.|::.:..:|||...|.
  Rat   174 ILECQPPRGHPEPTIYWKKDKVRID--EKEERISIRGG-----KLMISNTRKSDAGMYTCVGTNM 231

  Fly   661 ALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGD 725
            ..:|.:..| .|.|..||.|:..|.:..| :|.|..:...|.:.:|.| |.:|.||...:|: |.
  Rat   232 VGERDSDPA-ELTVFERPTFLRRPINQVV-LEDEPAEFRCQVQGDPQP-TVRWKKDDADLPR-GR 292

  Fly   726 HRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVS-ENIVVNP----- 784
            :.| .|..:|...:....|.|.|.|.|.|..|....:.|:.|.    ::.|: ...||.|
  Rat   293 YDI-KDDYTLRIKKAISADEGTYVCIAENRVGKVEASATLTVR----VRPVAPPQFVVRPRDQIV 352

  Fly   785 --GEDAMLSCTVEGKPLTEEHVKWERVGYDMTV-------KTSTTFANGTSYLHIKDAKREDVGN 840
              |......|..:|.|  :..|.|::.|....:       ..|....:.|..|.|.:.:|.|.|.
  Rat   353 AQGRTVTFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 415

  Fly   841 FRC----------------VADNRVDNPTNRDILLIVKFAPEIAKTP---TLLRAASGTGERGRL 886
            :.|                |.|...|.|           .|.|.:.|   ||  |..||   ..|
  Rat   416 YICQALTVAGSILAKAQLEVTDVLTDRP-----------PPIILQGPINQTL--AVDGT---ALL 464

  Fly   887 PCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNE 951
            .|:|.|.|.|...|.::.... :.|..:..:::        :.||.:..:..:|.|.|.|||.:.
  Rat   465 KCKATGEPLPVISWLKEGFTF-LGRDPRATIQD--------QGTLQIKNLRISDTGTYTCVATSS 520

  Fly   952 LGEAVETVRLEITSQ-------------PDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRV-- 1001
            .||...:..|::|..             |.||....:.:||.::|||:|.||..|.|.||..:
  Rat   521 SGETSWSAVLDVTESGATISKNYDTNDLPGPPSKPQVTDVTKNSVTLSWQPGTPGVLPASAYIIE 585

  Fly  1002 RYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSH 1066
            .:..:....::.:.....:...|:.|||.||:|||.|.:.|..|.|...|......|::..||:.
  Rat   586 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQ 650

  Fly  1067 PA------SSLGG------GP----PTTSQTP---------LGG-------TSGMLLVGVGAGI- 1098
            ..      ..||.      .|    |||.|..         :.|       |||:....|...:
  Rat   651 GVDHRQVQKELGDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQASTVWQNLD 715

  Fly  1099 -------VVVLLNVFVIGCCLHKRNEKRLKRGL------------------ELMPAELTEDSSNT 1138
                   ..||:|               ||:|:                  |......||::.:.
  Rat   716 AKVPTERSAVLVN---------------LKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSA 765

  Fly  1139 PNLVIIGISLAAFGFLLVNAS---------------LVAWFFVHQRRKKVAETTNQPAKTATIEM 1188
            |...:..:::.:.....::.|               ...|...::.|..:.:|.:...::..|..
  Rat   766 PPQSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFHINKTVDATIRSVVIGG 830

  Fly  1189 YAPS-SYNDTVTGETLSSVSEKSES------------YSNEGSSQPEYIDEVRKKAASTYLVEGS 1240
            ..|. .|...|...|.:.|..|||.            .:...:|..|.|.:|.|:.|   .:.|
  Rat   831 LFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQITDVVKQPA---FIAG- 891

  Fly  1241 DMPPPRYQKDGTLPVIYPNNVVNACTL------------PHPRHNNGSAAIHMTRDDQMLISKGV 1293
                                :..||.:            ...|....:.|:...|.|..|:|.|
  Rat   892 --------------------IGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNG- 935

  Fly  1294 YIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALD-FTAQPMPMAHLQPMTVTSLATNGGPTLI 1357
              ..|......|.|                ||...| :.|..:|:.:          :|.||..|
  Rat   936 --SRPGLLNTGDPS----------------YPWLADSWPATSLPVNN----------SNSGPNEI 972

  Fly  1358 GNGSVAAVAGGSGTLR---------RGILRGVVGVP--QPDVTHHTSTVGGSPMQMLHDLHPVNL 1411
            ||       .|.|..:         .||.:..:|:.  :.||.......|.....||.|  ....
  Rat   973 GN-------FGRGDFKHNVNKNLAEHGIKKEFLGMERNKNDVLPPVPGQGDKTATMLSD--GAIY 1028

  Fly  1412 SASTLTTSTTLNGS------LPTATATL--PRQPHGI---LKDPNRNKQQQQQQQQQQQQQQLQH 1465
            |:...||.||.|.|      .|.||..:  ....|.:   |.||       |.:...||:..|
  Rat  1029 SSIDFTTKTTYNSSSQITQATPYATTQILHSNSIHELAVDLPDP-------QWKSSVQQKSDL-- 1084

  Fly  1466 QQQLLNASLVGVGVPVSAP---LGSLQILNLPP--ASGGLGNNLLMT-TNAFDPTTVGLSSFGAV 1524
                       :|...|.|   .|:..:|.:|.  .:.||.|.:... :..|..|:...||..:.
  Rat  1085 -----------MGFAYSLPDQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSG 1138

  Fly  1525 SQAGG 1529
            |.:||
  Rat  1139 SLSGG 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	22/96 (23%)
		Ig	501..560	CDD:299845	18/72 (25%)
		Ig	584..666	CDD:299845	17/83 (20%)
		IG_like	585..666	CDD:214653	17/82 (21%)
		I-set	678..767	CDD:254352	26/88 (30%)
		IGc2	692..757	CDD:197706	20/64 (31%)
		Ig	788..849	CDD:143165	16/83 (19%)
		Ig	885..960	CDD:143165	18/74 (24%)
		FN3	967..1051	CDD:238020	28/85 (33%)
Robo2	XP_038944599.1	IgC_1_Robo	54..152	CDD:409490	25/106 (24%)
		Ig strand B	71..75	CDD:409490	1/3 (33%)
		Ig strand C	84..88	CDD:409490	1/3 (33%)
		Ig strand E	111..115	CDD:409490	0/3 (0%)
		Ig strand F	130..135	CDD:409490	2/4 (50%)
		Ig strand G	144..147	CDD:409490	1/2 (50%)
		Ig	159..244	CDD:416386	20/92 (22%)
		Ig strand A	159..162	CDD:409353	1/2 (50%)
		Ig strand A'	164..168	CDD:409353	0/3 (0%)
		Ig strand B	172..179	CDD:409353	2/6 (33%)
		Ig strand C	187..192	CDD:409353	1/4 (25%)
		Ig strand C'	194..197	CDD:409353	0/2 (0%)
		Ig strand D	203..207	CDD:409353	0/3 (0%)
		Ig strand E	209..215	CDD:409353	1/10 (10%)
		Ig strand F	222..230	CDD:409353	3/7 (43%)
		Ig strand G	233..244	CDD:409353	3/11 (27%)
		Ig	251..333	CDD:416386	24/85 (28%)
		Ig strand A	251..254	CDD:409353	0/2 (0%)
		Ig strand A'	256..260	CDD:409353	1/4 (25%)
		Ig strand B	263..272	CDD:409353	2/8 (25%)
		Ig strand C	278..283	CDD:409353	2/4 (50%)
		Ig strand C'	286..289	CDD:409353	0/2 (0%)
		Ig strand D	292..297	CDD:409353	1/5 (20%)
		Ig strand E	298..305	CDD:409353	1/6 (17%)
		Ig strand F	312..320	CDD:409353	4/7 (57%)
		Ig strand G	323..333	CDD:409353	2/9 (22%)
		IgI_4_Robo	342..439	CDD:409391	20/98 (20%)
		Ig strand B	358..362	CDD:409391	0/3 (0%)
		Ig strand C	371..375	CDD:409391	1/3 (33%)
		Ig strand E	401..405	CDD:409391	1/3 (33%)
		Ig strand F	415..420	CDD:409391	1/4 (25%)
		Ig strand G	428..431	CDD:409391	0/2 (0%)
		IgI_5_Robo	446..532	CDD:409544	26/99 (26%)
		Ig strand B	462..466	CDD:409544	1/3 (33%)
		Ig strand C	475..479	CDD:409544	0/3 (0%)
		Ig strand E	498..502	CDD:409544	2/3 (67%)
		Ig strand F	512..517	CDD:409544	2/4 (50%)
		Ig strand G	525..528	CDD:409544	0/2 (0%)
		FN3	549..642	CDD:238020	29/92 (32%)
		FN3	673..758	CDD:238020	16/99 (16%)
		FN3	767..859	CDD:238020	13/91 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910