DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	762	Identity:	187/762 - (24%)
Similarity:	275/762 - (36%)	Gaps:	172/762 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LRLLAVIVL------ASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFA 110
            :|:.|::||      .:.|.|...||      |.||.||.|.||.:.|.:....|.|||||.|.|
Human     4 MRVPALLVLLFCFRGRAGPSPHFLQQ------PEDLVVLLGEEARLPCALGAYWGLVQWTKSGLA 62

  Fly   111 LGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPA 175
            ||....:||:.||.:.|:...|.::|.|....:.|:|.|:||...|.|.|   ..|:|.|:.||.
Human    63 LGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPE 124

  Fly   176 SIEIKGYSHNSKVEVRENQDLQLKC-IVANAKPAAQIVWYRGNVEYKPEKREDT-VEESTAKRFT 238
            :.::.|   ...|.:.......|.| ...:|:|..:::|:|..|.........| ::|.|..  :
Human   125 APQVLG---GPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPG--S 184

  Fly   239 TTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTV 303
            ..|:|.|.|...||...:.|:||.:||.....  ..:.||:.|   ||.:...::..|::.|:.|
Human   185 VESTLTLTPFSHDDGATFVCRARSQALPTGRD--TAITLSLQY---PPEVTLSASPHTVQEGEKV 244

  Fly   304 ELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASN-VMSQNP 367
            ..:|::....|.....|.|.||.:..|  ...||.     ..|:|........||.|| |.|.|.
Human   245 IFLCQATAQPPVTGYRWAKGGSPVLGA--RGPRLE-----VVADASFLTEPVSCEVSNAVGSANR 302

  Fly   368 LKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKW-MVGGRQVRNATSKTIVS 431
            ..|   |.|||.|.......|....||:....:|... .||...:.| ..||.||. .:..|:..
Human   303 STA---LDVLFGPILQAKPEPVSVDVGEDASFSCAWR-GNPLPRVTWTRRGGAQVL-GSGATLRL 362

  Fly   432 PEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPA 496
            |..|.....:.....|..       ..||.....|   :..|:|     |||:::..........
Human   363 PSVGPEDAGDYVCRAEAG-------LSGLRGGAAE---ARLTVN-----APPVVTALHSAPAFLR 412

  Fly   497 GSVQKLLCVSSGGNPLATL-TWYKNDKRINSVIRAADKSVSAE----------ITIL----ANVS 546
            |..:....|.:...|.|.: :|.:......|..|...::..|.          |::|    ...|
Human   413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQES 477

  Fly   547 DNQAQYRCEASNSATE------------IPLFQ--------STTL-----------------SVH 574
            |....:.|.|.|...|            :|..:        :|||                 |..
Human   478 DFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASAS 542

  Fly   575 FAPETVKIRIEPEELRPGMEATIICDSSSSNPP--AKLSWWKDGIPIEGINNTSKPGLWGGTVST 637
            |:.:...:||      ||..     |.|||..|  .:....:|..||.   :|....|......|
Human   543 FSEQKNLMRI------PGSS-----DGSSSRGPEEEETGSREDRGPIV---HTDHSDLVLEEEGT 593

  Fly   638 LEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRP---KFVPPPSSTAVGVEGESLQVS 699
            ||     |::.....|..:..          :|||.:...|   .|:||||  .:|..|
Human   594 LE-----TKDPTNGYYKVRGV----------SVSLSLGEAPGGGLFLPPPS--PLGPPG------ 635

  Fly   700 LQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAG 746
                   ||..|.:......:|.               .||:|..||
Human   636 -------TPTFYDFNPHLGMVPP---------------CRLYRARAG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	37/96 (39%)
		Ig	76..155	CDD:299845	32/78 (41%)
		IG_like	186..279	CDD:214653	23/94 (24%)
		Ig	197..279	CDD:299845	22/83 (27%)
		IG_like	296..376	CDD:214653	23/80 (29%)
		Ig	300..361	CDD:299845	15/60 (25%)
		Ig	380..454	CDD:299845	16/74 (22%)
		IG_like	490..573	CDD:214653	20/134 (15%)
		Ig	501..560	CDD:299845	14/73 (19%)
		Ig	584..666	CDD:299845	18/83 (22%)
		IG_like	585..666	CDD:214653	17/82 (21%)
		I-set	678..767	CDD:254352	17/72 (24%)
		IGc2	692..757	CDD:197706	10/55 (18%)
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	37/91 (41%)
		IGc2	38..106	CDD:197706	27/67 (40%)
		I-set	126..224	CDD:254352	25/104 (24%)
		Ig2_KIRREL3-like	141..223	CDD:143236	22/85 (26%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	22/84 (26%)
		IG_like	234..308	CDD:214653	23/83 (28%)
		Ig	312..395	CDD:299845	19/94 (20%)
		I-set	317..395	CDD:254352	18/89 (20%)
		Ig	397..501	CDD:299845	19/103 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920