DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Jam3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_075766.1	Gene:	Jam3 / 83964	MGIID:	1933825	Length:	310	Species:	Mus musculus

Alignment Length:	273	Identity:	73/273 - (26%)
Similarity:	109/273 - (39%)	Gaps:	42/273 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   773 IKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFAN-------------G 824
            :||.:.|.||:..|...|||.:.....::..::|:::....|  |...|.|             |
Mouse    34 LKSSNRNPVVHEFESVELSCIITDSQTSDPRIEWKKIQDGQT--TYVYFDNKIQGDLAGRTDVFG 96

  Fly   825 TSYLHIKDAKREDVGNFRC--VADN---RVDNPTNRDILLIVKFAPEIAKTPTL-LRAASGTGER 883
            .:.|.|.:..|.|...:||  ||.|   .||..|   |.|||:..|   .||.. :.||...|:.
Mouse    97 KTSLRIWNVTRSDSAIYRCEVVALNDRKEVDEIT---IELIVQVKP---VTPVCRIPAAVPVGKT 155

  Fly   884 GRLPCR-AQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECV 947
            ..|.|: ::|.|:|.:.|.::...||.:.......:.......:...||:.:.|...|.|.|.|:
Mouse   156 ATLQCQESEGYPRPHYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFNAVHKDDSGQYYCI 220

  Fly   948 ARNELGEAVETVRLEITSQPDPPLSLNILNVTHDT-VTLAWTPGFDGGLKASYRVRYRMA---DR 1008
            |.|:.|.|    |.|  .|......|||..:.... |.|........|:..:||....::   |.
Mouse   221 ASNDAGAA----RCE--GQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDG 279

  Fly  1009 EQYKYIDGLPNSH 1021
            |.||    .|..|
Mouse   280 ESYK----SPGKH 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165	18/78 (23%)
		Ig	885..960	CDD:143165	19/75 (25%)
		FN3	967..1051	CDD:238020	14/59 (24%)
Jam3	NP_075766.1	Ig	37..118	CDD:299845	19/82 (23%)
		I-set	39..135	CDD:254352	27/100 (27%)
		Ig	156..231	CDD:143165	20/78 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910