DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and VTCN1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_011540445.2	Gene:	VTCN1 / 79679	HGNCID:	28873	Length:	332	Species:	Homo sapiens

Alignment Length:	241	Identity:	49/241 - (20%)
Similarity:	92/241 - (38%)	Gaps:	65/241 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 ITVVVEYG---------TTIKSVSENIVVNPGEDAMLSCTVEGK-PLTEEHVKWERVGY------ 811
            |.:::.:|         ||:.|..     |.|||.:||||.|.. .|::..::|.:.|.
Human    73 IALIIGFGISGRHSITVTTVASAG-----NIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHE 132

  Fly   812 ------------DMTVKTSTTFAN----GTSYLHIKDAKREDVGNFRC-VADNRVDNPTNRDILL 859
                        :|....:..||:    |.:.|.:|:.:..|.|.::| :..::.....|.:...
Human   133 FKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKT 197

  Fly   860 IVKFAPEIAKTPTLLRAASGTGERGRLPCRA-QGSPKPQFIWR----QDKKDLPINRTYKYEVEE 919
            .....||:...   ..|:|.|     |.|.| :..|:|..:|.    |......::.| .:|:..
Human   198 GAFSMPEVNVD---YNASSET-----LRCEAPRWFPQPTVVWASQVDQGANFSEVSNT-SFELNS 253

  Fly   920 R----KIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRL 961
            .    |:.|:.|..|:         ...|.|:..|::.:|...:::
Human   254 ENVTMKVVSVLYNVTI---------NNTYSCMIENDIAKATGDIKV 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	1/3 (33%)
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165	17/84 (20%)
		Ig	885..960	CDD:143165	17/83 (20%)
		FN3	967..1051	CDD:238020
VTCN1	XP_011540445.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910