DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Mcam

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_076473.2	Gene:	Mcam / 78967	RGDID:	620463	Length:	648	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	148/658 - (22%)
Similarity:	240/658 - (36%)	Gaps:	157/658 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 PTEARVGDIVPLTCTTA-PSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKR 451
            |.|..||:...|.|..| ||...::::|.:    :.......|.....|       ....||.:.
  Rat    37 PVEVEVGNTALLKCGPAHPSGNFSQVEWFL----IHKERQIPIFRVHQG-------KGQSEPGEY 90

  Fly   452 SLVVICHGLNMQLTENVVSTH-------------------TINVLYPPAPPLISGYMEGQIIPAG 497
            ...:..||....|..:.|:.|                   .:.|...|..|.|...:.|..:
  Rat    91 EHRLSLHGPGATLALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHV--- 152

  Fly   498 SVQKL----LCVSSGGNPLATLTWYKNDKRI----NSV-IRAADKSVSAEITILANV-------S 546
            .:|:|    .||...|.|:..:.||||.:.:    |.| |:::....|:.:..|.:|       .
  Rat   153 DIQELKEVATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKE 217

  Fly   547 DNQAQYRCEAS---NSATEIPLFQSTTLSVHFAPETVKIRIEPEE-LRPGMEATIICDSSSSNPP 607
            |..||:.||.|   .|...:...:..|:.|.:..|.|.:.:||.. |:.|....|.| .:..||.
  Rat   218 DKDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRC-LTDGNPQ 281

  Fly   608 AKLSWWKDGIPIEGI--NNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN-EALQRSAHEA 669
            ...:..|.....|.:  .:|.:.||         ..:...|:.:..||.|||.: |.....:.:.
  Rat   282 PHFTINKKNPSTEEMEEESTDENGL---------LSLEPAQKHHSGVYQCQSLDLETTVMLSSDP 337

  Fly   670 VSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGS 734
            :.|.|.|.......|::..| .||:||.::.:..:| ..:.::|.:|.|       .::...|..
  Rat   338 LELLVNYVSDVQVDPTAPEV-QEGDSLTLTCKAESN-QDLEFEWLRDKT-------GQLLGKGPI 393

  Fly   735 LNFTRLHRDDAGIYSCSAS--NSQG-GATLNITVVVEYGTTIKSVSENIVVNPGEDAM--LSCTV 794
            |....:.|:..|.|.|.||  :..| ..|..::|.: :|:...:..|. .|...|:||  |||..
  Rat   394 LQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGI-FGSPWMAAKER-KVWAQENAMLNLSCEA 456

  Fly   795 EGKPLTEEHVKWERVG----YDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNR 855
            .|.|  :..:.|...|    ::...:|..:..|......:.:...|      |.|.|.:.:.|..
  Rat   457 SGHP--QPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAE------CTASNSLGSNTTV 513

  Fly   856 DILLIV---KFAPEIAK-----TPTL---LRAASGTGE--------------------------- 882
            .||.:|   ...|:.::     |||:   .||.|.:.|
  Rat   514 IILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLG 578

  Fly   883 --------RGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYE-VEERKIDSLTYESTLIV----D 934
                    :|:|||...|           |:::.:..|.|.| |.|.|.|.|..|..|:.    |
  Rat   579 ATLYYFYKKGKLPCGRSG-----------KQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGD 632

  Fly   935 KVAPADYG 942
            |.||.|.|
  Rat   633 KRAPGDQG 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	14/66 (21%)
		IG_like	490..573	CDD:214653	25/101 (25%)
		Ig	501..560	CDD:299845	21/77 (27%)
		Ig	584..666	CDD:299845	20/85 (24%)
		IG_like	585..666	CDD:214653	20/84 (24%)
		I-set	678..767	CDD:254352	21/91 (23%)
		IGc2	692..757	CDD:197706	16/66 (24%)
		Ig	788..849	CDD:143165	15/66 (23%)
		Ig	885..960	CDD:143165	21/63 (33%)
		FN3	967..1051	CDD:238020
Mcam	NP_076473.2	Ig	34..134	CDD:299845	19/107 (18%)
		C2-set_2	141..236	CDD:285423	26/97 (27%)
		IG_like	260..323	CDD:214653	15/72 (21%)
		IGc2	266..323	CDD:197706	13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..304		3/21 (14%)
		IG_like	356..415	CDD:214653	17/67 (25%)
		IGc2	359..412	CDD:197706	14/60 (23%)
		IG_like	440..515	CDD:214653	18/83 (22%)
		Ig	452..515	CDD:299845	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..554		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..648		6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910