DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and nphs1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001035777.1	Gene:	nphs1 / 692352	ZFINID:	ZDB-GENE-051102-1	Length:	1242	Species:	Danio rerio

Alignment Length:	1300	Identity:	380/1300 - (29%)
Similarity:	592/1300 - (45%)	Gaps:	183/1300 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYN 135
            ||.|:|.|.::.|..||.|:::|||...:|||||.|||..|.....:||:||||:.||:|:|.|:
Zfish    26 QQAFKTEPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLRPLRSLPGYPRYSMTGDQKKGQYH 90

  Fly   136 LRISNASINDDADYQCQVGPAR-----LNSAIRANAKLTVISPPASIEIKGYSHNSKVEVRENQD 195
            |:|.:.::.||..|:||||.:.     ::..:..|.::....|...:|       |:....|.:.
Zfish    91 LQILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLE-------SEEPWVEGEQ 148

  Fly   196 LQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQA 260
            ..:.||..:|||.|:|..:|...|.. |....|:..|..|...|.:.:.::....||....||:|
Zfish   149 YTVTCIAPDAKPPAEITIFRDGEELL-ESESYTMSGSQDKLQNTHAEVTIRARSSDDTRRLTCRA 212

  Fly   261 RH----KALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWY 321
            ::    :||...|.|:      |.:||..|.|.|.. .|.::.|..::::|.|.||||.|.|.|.
Zfish   213 KNPASPRALETGMTMK------VYFPPQAPMIMGLE-NEEVKAGSFLKVVCMSYGGNPLATLHWT 270

  Fly   322 KNGSQIRMAYRTS--GRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVT 384
            |||..:..::...  .|.:.::.....:..||.|..:|::.|.::::|:.....|:|.|.|..||
Zfish   271 KNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTLTVPFEPAEVT 335

  Fly   385 VMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPE-GGWTTTSNITAVVEP 448
            ::|..||..|:.:.|:|:|:.||||..|:|.:|.::: |.|..|....: ||..|.||:|..|..
Zfish   336 LLGSFEAVEGEEINLSCSTSSSNPPVHIRWWLGFKEL-NRTEVTFAEGDNGGMMTVSNLTHKVSR 399

  Fly   449 NKRSLVVICHGLNMQLTENVVSTHTINVLYPP------APPLISGYMEGQIIPAGSVQKLLCVSS 507
            ....|.:.|...|.....:.|....:.|.|||      |||      ....:.:||..:|:|.||
Zfish   400 EDNGLSLQCEAFNKGTRFSSVRAAELIVYYPPQKVWLDAPP------PNVFLHSGSTLRLVCFSS 458

  Fly   508 GGNPLATLTWYKNDKRINSVIR--AADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTT 570
            ||||...|||.||:|.:.:..:  ::::.||.|:.:..:.|||.|.|||::||.|.:: |...|.
Zfish   459 GGNPTGQLTWLKNNKVVLTASKQVSSERGVSRELLLTLHPSDNLATYRCDSSNKAKKV-LSAQTK 522

  Fly   571 LSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTV 635
            ..|.|...:|||..:.:|||.|....:.|.:.||||.|.:||....:.::|::...|...:||..
Zfish   523 FRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSLGPVILKGVDQAPKRAEFGGMS 587

  Fly   636 STLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSL 700
            .|.:..:.:......:..|||:.:..|....:...|||||:.|:|..........:|.|:..:..
Zfish   588 RTSKLSLTLEPHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSAEQPDEVQVIEDETATLPA 652

  Fly   701 QTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITV 765
            :..|||..:|.:|...|..:.::.|.|......:|....:.|.|.|.|....||::|.....:.:
Zfish   653 KVSANPDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVNVSRRDGGDYIIECSNAEGSNRTKLRL 717

  Fly   766 VVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVG---YDMTVKTSTTFANGTSY 827
            .|:|..|::..|:.:.||.|:.|.|.|..:..|:|.....|:.:|   .|...:.|..  :||..
Zfish   718 DVQYSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGEGERDELGEESED--DGTGV 780

  Fly   828 LHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAAS-GTGER-GRLPCRA 890
            |.|.:..|:..|.::|.|||.:....:.:..|||:|||::.|.|...:.|| |.|.. ..:.|:|
Zfish   781 LTIYEVTRDRAGVYQCTADNGISPTGSVEGQLIVRFAPDLQKGPQWRKVASRGDGSNDANVVCQA 845

  Fly   891 QGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPA-DYGAYECVARNELGE 954
            ||.|:.||.|.::...|.:... :|| |..:.....:.|.|.|..|:.| ||..:.|.|.|.:||
Zfish   846 QGVPRVQFRWAKNGFPLDLGNP-RYE-ETTESTGTIHTSILTVINVSAALDYAIFTCTAHNSMGE 908

  Fly   955 AVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPN 1019
            ....::|..|:.||||..|.:|.|...:|||.|.|||||||...:||||:.|....|.|:|..|.
Zfish   909 DSLDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGGLTQIFRVRYQWAGSASYMYVDVFPP 973

  Fly  1020 SHKL-TIGGLRMNTLYLFSVMSWNELGQSSYLPD-----LARAETKEAPPPSHPASSLGGGPPTT 1078
            :..: |:.||..:|:|.|||.:.|.:|:|||..:     :..|:.|||          .||..|.
Zfish   974 TATVYTVTGLNPSTMYNFSVNALNSIGESSYADNNKILTVTTADAKEA----------DGGVSTA 1028

  Fly  1079 SQTPL---GGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPN 1140
            .|...   ||....::|.:..|.|:.|||.|:  |.|
Zfish  1029 DQDSALAGGGLPVYVVVILVVGGVLFLLNPFI--CFL---------------------------- 1063

  Fly  1141 LVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSS 1205
                               |..|    :||:.:...|                          ||
Zfish  1064 -------------------LARW----KRRRSLKGNT--------------------------SS 1079

  Fly  1206 VSE--KSESYSNEGSSQPEYIDE--VRKKAASTYLVEGSDMPP----PRYQKDGTLPVIYPNNVV 1262
            :|:  |||...:..||...|...  :...|..|.||:.|..|.    ..|.:.......||....
Zfish  1080 ISQETKSEEQRSTASSSTRYASRELINASAQRTLLVDSSSEPDSSVYESYGRQENPHYYYPTEAY 1144

  Fly  1263 NACTLPHP--------RHNNGSAAIHMTRDDQMLISKGVY--IPSPSPAPP--------PDGSYY 1309
            :.....||        ||.. |...|:..:     .:|:|  :.:.||.||        |..:||
Zfish  1145 SPALYAHPEGPEDCDGRHGT-SPFTHVYEE-----VRGMYEDLQACSPLPPAAHIHPQAPFSTYY 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	40/101 (40%)
		Ig	76..155	CDD:299845	37/78 (47%)
		IG_like	186..279	CDD:214653	25/96 (26%)
		Ig	197..279	CDD:299845	23/85 (27%)
		IG_like	296..376	CDD:214653	21/81 (26%)
		Ig	300..361	CDD:299845	18/62 (29%)
		Ig	380..454	CDD:299845	27/74 (36%)
		IG_like	490..573	CDD:214653	31/84 (37%)
		Ig	501..560	CDD:299845	26/60 (43%)
		Ig	584..666	CDD:299845	21/81 (26%)
		IG_like	585..666	CDD:214653	21/80 (26%)
		I-set	678..767	CDD:254352	20/88 (23%)
		IGc2	692..757	CDD:197706	17/64 (27%)
		Ig	788..849	CDD:143165	19/63 (30%)
		Ig	885..960	CDD:143165	24/75 (32%)
		FN3	967..1051	CDD:238020	40/84 (48%)
nphs1	NP_001035777.1	IG_like	33..126	CDD:214653	37/92 (40%)
		Ig	133..216	CDD:386229	23/90 (26%)
		Ig	261..313	CDD:386229	14/51 (27%)
		Ig	333..419	CDD:386229	29/86 (34%)
		ig	439..511	CDD:365836	28/77 (36%)
		IG_like	637..719	CDD:214653	18/81 (22%)
		Ig_3	723..800	CDD:372822	22/78 (28%)
		Ig_hNephrin_like	814..922	CDD:143250	36/109 (33%)
		FN3	921..1012	CDD:238020	40/90 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576439
Domainoid	1	1.000	94	1.000	Domainoid score	I7422
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20974
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm26237
orthoMCL	1	0.900	-	-		OOG6_107508
Panther	1	1.100	-	-	LDO	PTHR11640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4392
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790