DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Jam2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006523138.1	Gene:	Jam2 / 67374	MGIID:	1933820	Length:	339	Species:	Mus musculus

Alignment Length:	334	Identity:	80/334 - (23%)
Similarity:	134/334 - (40%)	Gaps:	84/334 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 LYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDG-TTIPQDGDHRIFAD--GGSLN 736
            :||  :.||.:||:     |:..|....:|:...|.::..|.. .|.|........:|  |||.|
Mouse     1 MYR--YSPPLTSTS-----EAFLVMASEKASTANVLWRGEKKSRMTRPGYCKSASCSDLIGGSRN 58

  Fly   737 FTRLHRD-DAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLT 800
             :|.|.| .|..:|.|..:.|     .:| |:|:                ::|:|:|... |..|
Mouse    59 -SRKHSDHKANGFSASKDHRQ-----EVT-VIEF----------------QEAILACKTP-KKTT 99

  Fly   801 EEHVKWERVGYDMTVKTSTTFANG---------TSYLHIKDAKREDVGNFRCVADNRVDNPTNR- 855
            ...::|::||..:::........|         ...:.||:..|.|.|.:||    .|..||.:
Mouse   100 SSRLEWKKVGQGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTRSDAGEYRC----EVSAPTEQG 160

  Fly   856 ------DILLIVKFAPEI--AKTPTLLRAASGTGERGRLPCR-AQGSPKPQFIWRQDKKDL---P 908
                  .::|.|..||.:  .:.||.:.    ||....|.|: .:|:|.|::||.:|...|   |
Mouse   161 QNLQEDKVMLEVLVAPAVPACEVPTSVM----TGSVVELRCQDKEGNPAPEYIWFKDGTSLLGNP 221

  Fly   909 INRTY---KYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPP 970
            ...|:   .|.:.       |....|..:.::..|.|.|.|.|||.:|.         ...|...
Mouse   222 KGGTHNNSSYTMN-------TKSGILQFNMISKMDSGEYYCEARNSVGH---------RRCPGKR 270

  Fly   971 LSLNILNVT 979
            :.:::||::
Mouse   271 MQVDVLNIS 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	24/92 (26%)
		IGc2	692..757	CDD:197706	18/68 (26%)
		Ig	788..849	CDD:143165	16/69 (23%)
		Ig	885..960	CDD:143165	22/81 (27%)
		FN3	967..1051	CDD:238020	3/13 (23%)
Jam2	XP_006523138.1	Ig	76..151	CDD:386229	18/97 (19%)
Jam2	XP_006523138.1	IGc2	190..262	CDD:197706	22/78 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910