DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Sirpb1b

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006530146.1	Gene:	Sirpb1b / 668101	MGIID:	3779828	Length:	408	Species:	Mus musculus

Alignment Length:	349	Identity:	91/349 - (26%)
Similarity:	143/349 - (40%)	Gaps:	64/349 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 ANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRG-----------N 217
            |..:|.||.|     :|.:.      |.......|.|.|.:..|...|.||||           .
Mouse    27 AMRELKVIQP-----VKSFF------VGAGGSATLNCTVTSLLPVGPIRWYRGVGQSRLLIQSFT 80

  Fly   218 VEYKPEKREDTVEESTAKRFTTTSSLKL-KPGPDDDYTEYTCQARHKALSPDMPMRA--TVQLSV 279
            .|:.|  |..:|.:.| ||.....|::: ...|.|..|.|..:.:..:...|..:::  ..:|||
Mouse    81 GEHFP--RITSVSDVT-KRNNLDFSIRISNVTPADSGTYYCVKFQRGSSESDREIQSGGGTELSV 142

  Fly   280 LYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNP-PAQLIWYKNGSQI------------RMAY 331
            |..|..|.:.|.:|....:  |||...|||.|..| ...|.|:|||::|            .::|
Mouse   143 LAKPSSPMVSGPAARAVPK--QTVTFTCRSHGFFPRNLTLKWFKNGNEISHLETSVEPEETSVSY 205

  Fly   332 RTSGRLSENIYTFTAEAGDNKARFRCEASNV-MSQNPLKAEVELS--VLFAPTHVTVMGPTEARV 393
            |.|..:.     ...|..|.:::..||..:| :.:.||:....:|  :...||......||  .|
Mouse   206 RVSSTVQ-----VVLEPRDVRSQIICEVDHVTLDRAPLRGIAHISEFIQVPPTLEISQQPT--MV 263

  Fly   394 GDIVPLTCTTAPSNPPA-EIKWMVGGRQVRNATSKT-IVSPEGGWTTTS----NITAVVEPNKRS 452
            .:::.:||......||. ::.|:..|...|.....| ||:.:|.:...|    ||:|:.|    :
Mouse   264 WNVIIVTCQIQKFYPPRFQVTWLENGNISRREVPFTLIVNKDGTYNWISCLLVNISALEE----N 324

  Fly   453 LVVICHGLNMQLTENVVSTHTINV 476
            :||.|. :.......|:.|||:.|
Mouse   325 MVVTCQ-VEHDGQAEVIETHTVVV 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	2/5 (40%)
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	24/106 (23%)
		Ig	197..279	CDD:299845	23/95 (24%)
		IG_like	296..376	CDD:214653	25/95 (26%)
		Ig	300..361	CDD:299845	21/73 (29%)
		Ig	380..454	CDD:299845	21/79 (27%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Sirpb1b	XP_006530146.1	Ig	32..143	CDD:386229	29/124 (23%)
		IgC_SIRP_domain_2	145..248	CDD:319314	29/109 (27%)
		IgC_SIRP_domain_3	250..352	CDD:319334	29/105 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910