DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Tmigd1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001369175.1	Gene:	Tmigd1 / 66601	MGIID:	1913851	Length:	294	Species:	Mus musculus

Alignment Length:	252	Identity:	65/252 - (25%)
Similarity:	101/252 - (40%)	Gaps:	47/252 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 LTVISPP-----ASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKRED 227
            |.|:|.|     :.:.:.|.:.|..::.:......|:|.|.|.....:::||          |||
Mouse    49 LVVLSLPQGRTSSVLTVNGRTENYILDTQHGVQASLECAVQNHTEDEELLWY----------RED 103

  Fly   228 TVEESTAKRFTTTSSLKLKP-GPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGY 291
            .:.:.........||:.:.| ...|:...:||:     |..|..:..||.|:|.:   ||.:.|
Mouse   104 GIVDLKNGNKINISSVCVSPINESDNGVRFTCK-----LQRDQTVSVTVVLNVTF---PPLLSG- 159

  Fly   292 SAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGS---------QIRMAYRTSGRLSENIYTFTAE 347
            :..:|:.....|.|:|..: .||.||::||||.|         ||... |.|.:||     .|..
Mouse   160 NGFQTVEENSDVSLVCNVK-SNPQAQMMWYKNNSALVLEKGRHQIHQT-RESFQLS-----ITKV 217

  Fly   348 AGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA 404
            ...:...:.|.||     :.||.|.....|.....|.|| |.|..:...|.:..|.|
Mouse   218 KKSDNGTYSCIAS-----SSLKMETMDFHLLVKDKVFVM-PAEPIIAACVVVVLTMA 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	1/1 (100%)
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	20/93 (22%)
		Ig	197..279	CDD:299845	20/82 (24%)
		IG_like	296..376	CDD:214653	26/88 (30%)
		Ig	300..361	CDD:299845	21/69 (30%)
		Ig	380..454	CDD:299845	8/25 (32%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Tmigd1	NP_001369175.1	IG_like	163..244	CDD:214653	27/92 (29%)
		Ig strand B	171..175	CDD:409353	2/3 (67%)
		Ig strand C	184..188	CDD:409353	1/3 (33%)
		Ig strand E	210..214	CDD:409353	2/8 (25%)
		Ig strand F	224..229	CDD:409353	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910