DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and SIGLEC1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_075556.1	Gene:	SIGLEC1 / 6614	HGNCID:	11127	Length:	1709	Species:	Homo sapiens

Alignment Length:	1658	Identity:	345/1658 - (20%)
Similarity:	545/1658 - (32%)	Gaps:	467/1658 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QQQQHIKWQQHATKRR-------------------RCRQHWIKHLQLLRLLAVIVLASAPVPSHA 69
            |:|..::||.....|.                   .....|..|.::||....:....|....|.
Human   168 QEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHL 232

  Fly    70 QQQ------KFRTTPHDLQVLEGAEAMMRCEVAN---VAGAVQWTKDGFALGFSAVIPGFPRYSV 125
            |.:      |...:|....:|.|....:.|:|.:   ...:::|.|||..|
Human   233 QVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL-------------- 283

  Fly   126 LGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEV 190
              ..|.|:  |.:..|:.:|...|.||.          .|...:::|||.|:.|    ..::|:|
Human   284 --QTKTGV--LHLPQAAWSDAGVYTCQA----------ENGVGSLVSPPISLHI----FMAEVQV 330

  Fly   191 R------ENQDLQLKCIVANAKPA-AQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPG 248
            .      |||.:.|.|...|..|: .:..||:.:|         .:|::    .:.|..|.|...
Human   331 SPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDA----HSHTLRLHLATR 382

  Fly   249 PDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGN 313
            .|..:  |.|:.::...|   .....|.:.|.:||..|.:..:.  || :.|....|.| |....
Human   383 ADTGF--YFCEVQNVHGS---ERSGPVSVVVNHPPLTPVLTAFL--ET-QAGLVGILHC-SVVSE 438

  Fly   314 PPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKAR-------------FRCEASNVMSQ 365
            |.|.|: ..:|..|..:  |||. |::...|:..:|.|..|             ::|.|:|.:..
Human   439 PLATLV-LSHGGHILAS--TSGD-SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499

  Fly   366 NPLKAEVELS---VLFAPTHVTVMGPTEARVGDIVPLTCTTAPS-NPPAEIKWMVGGRQVRNATS 426
            .....:...:   :|.:|.       .|...|..|.|:|.:..| .|.|...|.:.|..:.....
Human   500 ATSTLDFHANAARLLISPA-------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG 557

  Fly   427 KTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEG 491
            .:::.|....|...:..             |...:........|...:.|||||..|..:..::.
Human   558 SSLLLPAASSTDAGSYH-------------CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609

  Fly   492 QIIPAGSVQK--LLC-VSSGGNPLATLTWYKNDKRINSVIRAADK-------SVSAEITILAN-- 544
            ....||:.::  ||| |.|  :|.|.|.....|:.:.:.:.:...       |...::|...|
Human   610 DAAGAGAGRRGLLLCRVDS--DPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLL 672

  Fly   545 -------VSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE-LRPGMEATIICDS 601
                   :.:.:..|.|||||:      ..:.:.|..|..:...:.|.|.. |:.|.||.:.|:.
Human   673 RVEIHNPLLEEEGLYLCEASNA------LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNV 731

  Fly   602 S--SSNPPAKLSWWKDGIPIEGINNTSKPGLWG-GTVSTLEFRVNVTQEMNGQVYTCQSANEA-L 662
            |  ::..||..||:::|:            ||. |.:.|:  .:......:..:|.|:...|| .
Human   732 SREAAGSPANFSWFRNGV------------LWAQGPLETV--TLLPVARTDAALYACRILTEAGA 782

  Fly   663 QRSAHEAVSLDVLY---RPK--------------FVPPPSSTAVGV----EGESLQVSLQTRANP 706
            |.|.  .|.|.|||   |||              |:....|..:.:    .||.|..
Human   783 QLST--PVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA-------- 837

  Fly   707 TPVTYKWTKDGTTIPQDGDHRIFADGGSLNF--TRLHRDDAGIYSCSASNSQGGATLNITVVVEY 769
                   |..|..:|..|..:..|:..||..  ..|...|:|.|.|.|:|..|.:..::...|.
Human   838 -------TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR- 894

  Fly   770 GTTIKSVSENIVVNPGEDAMLSCTVE-GKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDA 833
            |..:: ||.:..:..|:..:|||.|. |.|....: :|.|.|..:...||.|       |.....
Human   895 GAWVQ-VSPSPELQEGQAVVLSCQVHTGVPEGTSY-RWYRDGQPLQESTSAT-------LRFAAI 950

  Fly   834 KREDVGNFRCVADNRVDNPTN--RDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKP 896
            .....|.:.|.|.......|:  ..|.|.|.:||......||:  .:|.|..|.|.||....|..
Human   951 TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM--DTGPGRLGLLLCRVDSDPPA 1013

  Fly   897 QFIWRQDKKDLPINRTYK----YEVEERKIDSLTYESTLIVD--KVAPADYGAYECVARNELGEA 955
            |.  |....|..:..|.:    .|....::......:||.::  .....|.|.|.|.|.|.||:|
Human  1014 QL--RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076

  Fly   956 VETVRLE---ITSQPDPPLSL---NILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYI 1014
            ..:...:   :..|..|..::   .::|:|    .|.||.              ..|......|.
Human  1077 SASADFDAQAVNVQVWPGATVREGQLVNLT----CLVWTT--------------HPAQLTYTWYQ 1123

  Fly  1015 DG----------LPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKE---APP--- 1063
            ||          |||   :|:   |..|.|...|      |.....|.|:|..|.:   ||.
Human  1124 DGQQRLDAHSIPLPN---VTV---RDATSYRCGV------GPPGRAPRLSRPITLDVLYAPRNLR 1176

  Fly  1064 -----PSHPAS------SLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNE 1117
                 .||...      ::...||  :|..|.....:|.....|.:...|.        |..|..
Human  1177 LTYLLESHGGQLALVLCTVDSRPP--AQLALSHAGRLLASSTAASVPNTLR--------LELRGP 1231

  Fly  1118 KRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAK 1182
            :....|.....|......:||      .:.|...|..::.|...|          |.|.......
Human  1232 QPRDEGFYSCSARSPLGQANT------SLELRLEGVRVILAPEAA----------VPEGAPITVT 1280

  Fly  1183 TATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKA-ASTYLVEGSDMPPPR 1246
            .|....:||:.|.....|..|......|.|:.            |..:| |..|..:..|....|
Human  1281 CADPAAHAPTLYTWYHNGRWLQEGPAASLSFL------------VATRAHAGAYSCQAQDAQGTR 1333

  Fly  1247 YQKDGTLPVIY-PNNVVNA--------------CTLPHPRHNNGSAAIHMTRDDQML-ISKGVYI 1295
            ..:...|.|:| |.:.|.:              ||:    .:...|.:.::.|.::| .|.||:.
Human  1334 SSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTV----DSEPPAELALSHDGKVLATSSGVHS 1394

  Fly  1296 PSP----------------SPAPPPDGSY----------------YNMNSDRYLSYPPMEYP--A 1326
            .:.                ...|..|.:|                ..:...|.::.|.::.|  |
Human  1395 LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGA 1459

  Fly  1327 ALDFTAQPMPMAHLQPMTVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGVPQPDV--T 1389
            ||:.:.:.:                |||..:||.:.|.....         |.:...|.|.:  |
Human  1460 ALNLSCRLL----------------GGPGPVGNSTFAWFWND---------RRLHAEPVPTLAFT 1499

  Fly  1390 H---------H------TSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSL-----------PT 1428
            |         |      |.....:|: ||..|:|.  ...|:.......|.|           |.
Human  1500 HVARAQAGMYHCLAELPTGAAASAPV-MLRVLYPP--KTPTMMVFVEPEGGLRGILDCRVDSEPL 1561

  Fly  1429 ATATL---------------PRQPH-GILKDPN 1445
            |:.||               |.:|| .:|..||
Human  1562 ASLTLHLGSRLVASSQPQGAPAEPHIHVLASPN 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	20/99 (20%)
		Ig	76..155	CDD:299845	18/81 (22%)
		IG_like	186..279	CDD:214653	21/99 (21%)
		Ig	197..279	CDD:299845	16/82 (20%)
		IG_like	296..376	CDD:214653	21/95 (22%)
		Ig	300..361	CDD:299845	19/73 (26%)
		Ig	380..454	CDD:299845	13/74 (18%)
		IG_like	490..573	CDD:214653	20/101 (20%)
		Ig	501..560	CDD:299845	18/77 (23%)
		Ig	584..666	CDD:299845	22/86 (26%)
		IG_like	585..666	CDD:214653	21/85 (25%)
		I-set	678..767	CDD:254352	22/108 (20%)
		IGc2	692..757	CDD:197706	17/66 (26%)
		Ig	788..849	CDD:143165	16/61 (26%)
		Ig	885..960	CDD:143165	20/80 (25%)
		FN3	967..1051	CDD:238020	19/96 (20%)
SIGLEC1	NP_075556.1	Ig	21..136	CDD:299845
		IG_like	26..135	CDD:214653
		Sialic acid binding. /evidence=ECO:0000250	122..126
		C2-set_2	142..228	CDD:285423	10/59 (17%)
		Ig_2	245..323	CDD:290606	23/105 (22%)
		IG_like	247..323	CDD:214653	23/103 (22%)
		Ig	336..408	CDD:299845	19/89 (21%)
		IG_like	338..408	CDD:214653	19/87 (22%)
		Ig	430..503	CDD:143165	19/77 (25%)
		IG_like	431..503	CDD:214653	19/76 (25%)
		Ig_2	514..594	CDD:290606	16/99 (16%)
		IG	516..594	CDD:214652	15/97 (15%)
		IG_like	624..703	CDD:214653	17/86 (20%)
		IG_like	715..792	CDD:214653	24/92 (26%)
		ig	715..788	CDD:278476	22/88 (25%)
		Ig	809..893	CDD:299845	20/98 (20%)
		I-set	898..980	CDD:254352	22/90 (24%)
		Ig_2	900..980	CDD:290606	22/87 (25%)
		Ig	1003..1080	CDD:143165	20/78 (26%)
		Ig_2	1093..1168	CDD:290606	23/104 (22%)
		IG_like	1093..1168	CDD:214653	23/104 (22%)
		I-set	1186..1256	CDD:254352	13/85 (15%)
		Ig_2	1263..1342	CDD:290606	19/100 (19%)
		IG_like	1271..1342	CDD:214653	17/82 (21%)
		Ig	1363..1442	CDD:299845	11/82 (13%)
		IG_like	1455..1529	CDD:214653	20/99 (20%)
		Ig	1457..1518	CDD:299845	15/85 (18%)
		Ig	<1552..1630	CDD:299845	10/43 (23%)
		IG	1552..1627	CDD:214652	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910